STRINGSTRING
PARD6B PARD6B CCN2 CCN2 TP53BP2 TP53BP2 BMP4 BMP4 A0A4W2EFN2 A0A4W2EFN2 CCND3 CCND3 WNT8B WNT8B BMPR2 BMPR2 CCND1 CCND1 TGFBR2 TGFBR2 ACTBL2 ACTBL2 DLG2 DLG2 DLG4 DLG4 BIRC5 BIRC5 SCRIB SCRIB FZD10 FZD10 LEF1 LEF1 PPP1CC PPP1CC DLG3 DLG3 ACTB ACTB LLGL2 LLGL2 LOC113888945 LOC113888945 TEAD3 TEAD3 SMAD1 SMAD1 WNT7B WNT7B AFP AFP LRRC1 LRRC1 PPP1CA PPP1CA SMAD4 SMAD4 SERPINE1 SERPINE1 LIMD1 LIMD1 A0A4W2DLG1 A0A4W2DLG1 AXIN1 AXIN1 BMPR1B BMPR1B WWTR1 WWTR1 GLI2 GLI2 GDF7 GDF7 DVL1 DVL1 TEAD1 TEAD1 A0A4W2DDT7 A0A4W2DDT7 BMPR1A BMPR1A MOB1B MOB1B WNT9B WNT9B FBXW11 FBXW11 WNT1 WNT1 WNT2B WNT2B PPP2R2B PPP2R2B FZD4 FZD4 WNT8A WNT8A PRKCI PRKCI WNT3A WNT3A TCF7L1 TCF7L1 PPP2CA PPP2CA MOB1A MOB1A PPP2CB PPP2CB NF2 NF2 GDF5 GDF5 TGFB2 TGFB2 YWHAH YWHAH LOC113890087 LOC113890087 MYC MYC DLG5 DLG5 TEAD2 TEAD2 ACTL8 ACTL8 ID1 ID1 SMAD7 SMAD7 FZD2 FZD2 BBC3 BBC3 SNAI2 SNAI2 FZD8 FZD8 SAV1 SAV1 FRMD6 FRMD6 CCND2 CCND2 WNT10A WNT10A WNT16 WNT16 YWHAQ YWHAQ CTNNA3 CTNNA3 TP73 TP73 TCF7L2 TCF7L2 CSNK1D CSNK1D PRKCZ PRKCZ BMP2 BMP2 CTNNA1 CTNNA1 FZD1 FZD1 TCF7 TCF7 WNT2 WNT2 WNT5A WNT5A WWC1 WWC1 LATS2 LATS2 YWHAE YWHAE SRY SRY YWHAG YWHAG CTNNB1 CTNNB1 BMP6 BMP6 SMAD2 SMAD2 A0A4W2BU60 A0A4W2BU60 RASSF1 RASSF1 YAP1 YAP1 BMP5 BMP5 CSNK1E CSNK1E LLGL1 LLGL1 A0A4W2C2Q0 A0A4W2C2Q0 CRB1 CRB1 WNT5B WNT5B BTRC BTRC A0A4W2C584 A0A4W2C584 TEAD4 TEAD4 WNT7A WNT7A APC APC DVL2 DVL2 PARD6A PARD6A CTNNA2 CTNNA2 ITGB2 ITGB2 PATJ PATJ AREG AREG APC2 APC2 DVL3 DVL3 SMAD3 SMAD3 AMH AMH TGFB3 TGFB3 PPP1CB PPP1CB FZD3 FZD3 NKD2 NKD2 FGF1 FGF1 TGFBR1 TGFBR1 STK3 STK3 YWHAB YWHAB WNT6 WNT6 NKD1 NKD1 YWHAZ YWHAZ CRB2 CRB2 GDF6 GDF6 LATS1 LATS1 CDH1 CDH1 WNT10B WNT10B GSK3B GSK3B ID2 ID2 PPP2R1A PPP2R1A DLG1 DLG1 FZD5 FZD5 A0A4W2D367 A0A4W2D367 A0A4W2D4T7 A0A4W2D4T7 AJUBA AJUBA PPP2R2A PPP2R2A FZD6 FZD6 LDAH LDAH RASSF6 RASSF6 PPP2R2C PPP2R2C MPP5 MPP5 WNT4 WNT4 WNT9A WNT9A BMP7 BMP7 A0A4W2DDK0 A0A4W2DDK0 WTIP WTIP WNT3 WNT3 PPP2R1B PPP2R1B WNT11 WNT11 A0A4W2CET6 A0A4W2CET6 A0A4W2CGD5 A0A4W2CGD5 FZD7 FZD7 BIRC3 BIRC3 A0A4W2CH33 A0A4W2CH33 PARD3 PARD3 TGFB1 TGFB1 AXIN2 AXIN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PARD6BPar-6 family cell polarity regulator beta. (430 aa)
CCN2Cellular communication network factor 2. (464 aa)
TP53BP2Tumor protein p53 binding protein 2. (1244 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
A0A4W2EFN2Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1409 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (428 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
ACTBL2Actin beta like 2. (376 aa)
DLG2Discs large MAGUK scaffold protein 2. (1009 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (754 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
SCRIBScribble planar cell polarity protein. (1603 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
LEF1Lymphoid enhancer binding factor 1. (430 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (848 aa)
ACTBActin beta. (375 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1022 aa)
LOC113888945Uncharacterized protein. (623 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (435 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (472 aa)
AFPAlpha fetoprotein. (610 aa)
LRRC1Leucine rich repeat containing 1. (762 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (641 aa)
LIMD1LIM domains containing 1. (674 aa)
A0A4W2DLG114_3_3 domain-containing protein; Belongs to the 14-3-3 family. (243 aa)
AXIN1Axin 1. (909 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (526 aa)
WWTR1WW domain containing transcription regulator 1. (412 aa)
GLI2GLI family zinc finger 2. (1573 aa)
GDF7Growth differentiation factor 7. (411 aa)
DVL1Dishevelled segment polarity protein 1. (708 aa)
TEAD1TEA domain transcription factor 1. (648 aa)
A0A4W2DDT7Uncharacterized protein. (554 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MOB1BMOB kinase activator 1B. (221 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (552 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (636 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
TCF7L1Transcription factor 7 like 1. (588 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
MOB1AMOB kinase activator 1A. (216 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
NF2Neurofibromin 2. (596 aa)
GDF5Growth differentiation factor 5. (499 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
LOC113890087TGF_BETA_2 domain-containing protein. (405 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1946 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
ACTL8Actin like 8; Belongs to the actin family. (365 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
BBC3Uncharacterized protein. (193 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (661 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
FRMD6FERM domain containing 6. (622 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (421 aa)
CTNNA3Catenin alpha 3. (895 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (640 aa)
TCF7L2Transcription factor 7 like 2. (652 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (447 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
CTNNA1Catenin alpha 1. (919 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (645 aa)
TCF7Transcription factor 7. (473 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WWC1WW and C2 domain containing 1. (1110 aa)
LATS2Large tumor suppressor kinase 2. (1015 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (268 aa)
SRYSex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development; Belongs to the SRY family. (205 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
CTNNB1Catenin beta 1. (774 aa)
BMP6Bone morphogenetic protein 6. (525 aa)
SMAD2Mothers against decapentaplegic homolog. (626 aa)
A0A4W2BU60Uncharacterized protein. (82 aa)
RASSF1Ras association domain family member 1. (340 aa)
YAP1Yes associated protein 1. (507 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
CSNK1EProtein kinase domain-containing protein. (490 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1153 aa)
A0A4W2C2Q0Uncharacterized protein. (572 aa)
CRB1Crumbs cell polarity complex component 1. (1408 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (616 aa)
A0A4W2C584Uncharacterized protein. (792 aa)
TEAD4TEA domain transcription factor 4. (652 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
APCAPC regulator of WNT signaling pathway. (2912 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
PARD6APar-6 family cell polarity regulator alpha. (344 aa)
CTNNA2Catenin alpha 2. (953 aa)
ITGB2Integrin beta. (769 aa)
PATJPATJ crumbs cell polarity complex component. (1907 aa)
AREGAmphiregulin. (247 aa)
APC2APC regulator of WNT signaling pathway 2. (2264 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
AMHAnti-Mullerian hormone. (560 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (445 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (483 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
STK3Serine/threonine kinase 3. (491 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (471 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
CRB2Crumbs cell polarity complex component 2. (1281 aa)
GDF6Growth differentiation factor 6. (470 aa)
LATS1Large tumor suppressor kinase 1. (1123 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (433 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
A0A4W2D367FERM domain-containing protein. (476 aa)
A0A4W2D4T7Uncharacterized protein. (356 aa)
AJUBAAjuba LIM protein. (564 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (484 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
LDAHLipid droplet associated hydrolase. (325 aa)
RASSF6Ras association domain family member 6. (368 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (428 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (585 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
A0A4W2DDK0TGF_BETA_2 domain-containing protein. (405 aa)
WTIPWT1 interacting protein. (455 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (805 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
A0A4W2CET6Serine/threonine-protein phosphatase. (259 aa)
A0A4W2CGD514_3_3 domain-containing protein. (110 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
A0A4W2CH33Metallophos domain-containing protein. (127 aa)
PARD3Par-3 family cell polarity regulator. (1355 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
AXIN2Axin 2. (836 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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