STRINGSTRING
FZD3 FZD3 TBX3 TBX3 LIF LIF POU5F1 POU5F1 WNT5B WNT5B ISL2 ISL2 MAPK11 MAPK11 KAT6A KAT6A NODAL NODAL ONECUT2 ONECUT2 SMAD2 SMAD2 RAF1 RAF1 ACVR2B ACVR2B CTNNB1 CTNNB1 SMAD9 SMAD9 HESX1 HESX1 SRY SRY BMP4 BMP4 INHBC INHBC A0A4W2EN65 A0A4W2EN65 ACVR1B ACVR1B ESRRB ESRRB SMAD3 SMAD3 DVL3 DVL3 MYF5 MYF5 HOXD1 HOXD1 APC2 APC2 DLX5 DLX5 ONECUT3 ONECUT3 NEUROG1 NEUROG1 PIK3R3 PIK3R3 JAK3 JAK3 ZIC1 ZIC1 RIF1 RIF1 ID3 ID3 WNT5A WNT5A WNT2 WNT2 TCF7 TCF7 LINC01862 LINC01862 ISL1 ISL1 SMAD5 SMAD5 FZD1 FZD1 AKT1 AKT1 PIK3R2 PIK3R2 MAP2K2 MAP2K2 PCGF6 PCGF6 WNT16 WNT16 COMMD3 COMMD3 WNT10A WNT10A JAK1 JAK1 LHX1 LHX1 FZD8 FZD8 PCGF5 PCGF5 FZD2 FZD2 A0A4W2GYG4 A0A4W2GYG4 ID1 ID1 A0A4W2H6U5 A0A4W2H6U5 MYC MYC HRAS HRAS HOXB1 HOXB1 WNT3A WNT3A SKIL SKIL WNT8A WNT8A KLF4 KLF4 NFIL3 NFIL3 FZD4 FZD4 WNT2B WNT2B WNT1 WNT1 IGF1 IGF1 JAK2 JAK2 WNT9B WNT9B MAPK3 MAPK3 IGF1R IGF1R JARID2 JARID2 BMPR1A BMPR1A PCGF1 PCGF1 WNT8B WNT8B BMPR2 BMPR2 ESRRG ESRRG LOC113906456 LOC113906456 FGF2 FGF2 AKT3 AKT3 PRRX1 PRRX1 STAT3 STAT3 OTX1 OTX1 ZFHX3 ZFHX3 LHX5 LHX5 PAX6 PAX6 A0A4W2E2H8 A0A4W2E2H8 FZD10 FZD10 MEIS1 MEIS1 PIK3CB PIK3CB KRAS KRAS ACVR1C ACVR1C ACVR1 ACVR1 MAPK13 MAPK13 TBX2 TBX2 SMAD1 SMAD1 WNT7B WNT7B ID4 ID4 ERAS ERAS SMAD4 SMAD4 PIK3CA PIK3CA NRAS NRAS INHBB INHBB HAND1 HAND1 AXIN1 AXIN1 BMPR1B BMPR1B TCF3 TCF3 SMARCAD1 SMARCAD1 REST REST A0A4W2DC93 A0A4W2DC93 SETDB1 SETDB1 WNT9A WNT9A WNT4 WNT4 INHBE INHBE FZD6 FZD6 HOXA1 HOXA1 FGFR4 FGFR4 PCGF3 PCGF3 MAP2K1 MAP2K1 CSDE1 CSDE1 FZD5 FZD5 FGFR3 FGFR3 ID2 ID2 GSK3B GSK3B WNT10B WNT10B MEIS2 MEIS2 IL6ST IL6ST A0A4W2CT92 A0A4W2CT92 PIK3CD PIK3CD ZIC2 ZIC2 INHBA INHBA WNT6 WNT6 ONECUT1 ONECUT1 MAPK1 MAPK1 A0A4W2CLL2 A0A4W2CLL2 DVL1 DVL1 FGFR2 FGFR2 GRB2 GRB2 AXIN2 AXIN2 AKT2 AKT2 FZD7 FZD7 A0A4W2CFZ8 A0A4W2CFZ8 WNT11 WNT11 MAPK12 MAPK12 WNT3 WNT3 FGFR1 FGFR1 LIFR LIFR DVL2 DVL2 APC APC NANOG NANOG WNT7A WNT7A PIK3R1 PIK3R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
TBX3T-box transcription factor 3. (748 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
POU5F1POU domain protein. (360 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
ISL2ISL LIM homeobox 2. (359 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2018 aa)
NODALNodal growth differentiation factor. (346 aa)
ONECUT2One cut domain family member. (557 aa)
SMAD2Mothers against decapentaplegic homolog. (626 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (830 aa)
CTNNB1Catenin beta 1. (774 aa)
SMAD9Mothers against decapentaplegic homolog. (430 aa)
HESX1HESX homeobox 1. (215 aa)
SRYSex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development; Belongs to the SRY family. (205 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
INHBCInhibin subunit beta C. (352 aa)
A0A4W2EN65POU-specific domain-containing protein. (264 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa)
ESRRBEstrogen related receptor beta. (454 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
HOXD1Homeobox D1. (322 aa)
APC2APC regulator of WNT signaling pathway 2. (2264 aa)
DLX5Distal-less homeobox 5. (289 aa)
ONECUT3One cut domain family member. (492 aa)
NEUROG1Neurogenin 1. (247 aa)
PIK3R3Uncharacterized protein. (461 aa)
JAK3Tyrosine-protein kinase. (1181 aa)
ZIC1Zic family member 1. (503 aa)
RIF1Replication timing regulatory factor 1. (2465 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
TCF7Transcription factor 7. (473 aa)
LINC01862Long intergenic non-protein coding RNA 1862. (291 aa)
ISL1ISL LIM homeobox 1. (349 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (645 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
PIK3R2Uncharacterized protein. (724 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
PCGF6Polycomb group ring finger 6. (351 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
COMMD3RING-type domain-containing protein. (469 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
JAK1Tyrosine-protein kinase. (1110 aa)
LHX1LIM homeobox 1. (406 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (661 aa)
PCGF5Polycomb group ring finger 5. (256 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
A0A4W2H6U5Uncharacterized protein. (428 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
HOXB1Homeobox B1. (302 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
SKILSKI like proto-oncogene. (684 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
KLF4Kruppel like factor 4. (499 aa)
NFIL3Nuclear factor, interleukin 3 regulated. (468 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
IGF1Insulin like growth factor 1. (188 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1252 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
ESRRGEstrogen related receptor gamma. (458 aa)
LOC113906456Left-right determination factor. (367 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
PRRX1Paired related homeobox 1. (245 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
OTX1Orthodenticle homeobox 1. (355 aa)
ZFHX3Zinc finger homeobox 3. (3706 aa)
LHX5LIM homeobox 5. (402 aa)
PAX6Paired box 6. (455 aa)
A0A4W2E2H8Uncharacterized protein. (1615 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
MEIS1Meis homeobox 1. (492 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (492 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
TBX2T-box transcription factor 2. (714 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (472 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (164 aa)
ERASES cell expressed Ras. (185 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
INHBBInhibin subunit beta B. (398 aa)
HAND1Heart and neural crest derivatives expressed 1. (394 aa)
AXIN1Axin 1. (909 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (526 aa)
TCF3Transcription factor 3. (640 aa)
SMARCAD1Uncharacterized protein. (1029 aa)
RESTRE1 silencing transcription factor. (1004 aa)
A0A4W2DC93POU-specific domain-containing protein. (192 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1290 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (585 aa)
INHBEInhibin subunit beta E. (348 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
HOXA1Homeobox A1. (333 aa)
FGFR4Fibroblast growth factor receptor. (800 aa)
PCGF3Polycomb group ring finger 3. (242 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
CSDE1Cold shock domain containing E1. (844 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (433 aa)
MEIS2Meis homeobox 2. (477 aa)
IL6STInterleukin 6 signal transducer. (935 aa)
A0A4W2CT92Left-right determination factor. (367 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
ZIC2Zic family member 2. (525 aa)
INHBAInhibin subunit beta A. (425 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ONECUT1One cut domain family member. (712 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
A0A4W2CLL2POU-specific domain-containing protein. (115 aa)
DVL1Dishevelled segment polarity protein 1. (708 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
AXIN2Axin 2. (836 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
A0A4W2CFZ8C2H2-type domain-containing protein. (140 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
FGFR1Fibroblast growth factor receptor. (856 aa)
LIFRLIF receptor subunit alpha. (1095 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
APCAPC regulator of WNT signaling pathway. (2912 aa)
NANOGHomeobox domain-containing protein. (285 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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