STRINGSTRING
PRKACA PRKACA ITGB1 ITGB1 GNA13 GNA13 VASP VASP PTGIR PTGIR ARHGAP35 ARHGAP35 ACTL8 ACTL8 PRKACB PRKACB RAP1B RAP1B P2RY1 P2RY1 LOC113901022 LOC113901022 DHRSX DHRSX MYLK3 MYLK3 PRKCI PRKCI TLNRD1 TLNRD1 ITPR1 ITPR1 ADCY9 ADCY9 PLCB3 PLCB3 RASGRP2 RASGRP2 ITPR3 ITPR3 MAPK11 MAPK11 PIK3R5 PIK3R5 VWF VWF PIK3R1 PIK3R1 GP9 GP9 MYL12A MYL12A MYL12B MYL12B ITGA2 ITGA2 LCP2 LCP2 PLCB1 PLCB1 A0A4W2CEF6 A0A4W2CEF6 MAPK12 MAPK12 GUCY1A1 GUCY1A1 STIM1 STIM1 APBB1IP APBB1IP AKT2 AKT2 ARHGEF1 ARHGEF1 FGG FGG FGA FGA A0A4W2CL25 A0A4W2CL25 ZNF408 ZNF408 DGCR6L DGCR6L MAPK1 MAPK1 PIK3CD PIK3CD RDH14 RDH14 PLCB2 PLCB2 GNAS GNAS PTGS1 PTGS1 MYLK2 MYLK2 ADCY2 ADCY2 ROCK2 ROCK2 PLA2G4E PLA2G4E MYLK MYLK A0A4W2CZ07 A0A4W2CZ07 PTRHD1 PTRHD1 ADCY6 ADCY6 CPN2 CPN2 NOS3 NOS3 GP5 GP5 PRKG2 PRKG2 ADCY4 ADCY4 TLN1 TLN1 F2R F2R TLN2 TLN2 A0A4W2DC91 A0A4W2DC91 ITPR2 ITPR2 TBXA2R TBXA2R GNAI1 GNAI1 SYK SYK PIK3CG PIK3CG FERMT3 FERMT3 PIK3CA PIK3CA PPP1CA PPP1CA A0A4W2DSL7 A0A4W2DSL7 MYLK4 MYLK4 MAPK13 MAPK13 P2RY12 P2RY12 ROCK1 ROCK1 GUCY1A2 GUCY1A2 FGB FGB JMJD7 JMJD7 MAPK3 MAPK3 PRKG1 PRKG1 PIK3CB PIK3CB ACTB ACTB ADCY7 ADCY7 PPP1CC PPP1CC ORAI1 ORAI1 ADCY8 ADCY8 PIK3R6 PIK3R6 A0A4W2E5U2 A0A4W2E5U2 PLA2G4A PLA2G4A ACTBL2 ACTBL2 PLCB4 PLCB4 ARHGEF12 ARHGEF12 ADCY1 ADCY1 AKT3 AKT3 RDH13 RDH13 PLA2G4D PLA2G4D RASGRP1 RASGRP1 LYN LYN F2 F2 P2RX1 P2RX1 SNAP23 SNAP23 FYN FYN PTK6 PTK6 PLA2G4F PLA2G4F ADCY3 ADCY3 PPP1CB PPP1CB ADCY5 ADCY5 TBXAS1 TBXAS1 LRRC15 LRRC15 GNAI3 GNAI3 PPP1R12A PPP1R12A PIK3R3 PIK3R3 COL3A1 COL3A1 PLCG2 PLCG2 COL1A1 COL1A1 GNAI2 GNAI2 GNAQ GNAQ VAMP8 VAMP8 RHOA RHOA SRC SRC AKT1 AKT1 PIK3R2 PIK3R2 COL1A2 COL1A2 GUCY1B1 GUCY1B1 PRKCZ PRKCZ RAP1A RAP1A GP1BB GP1BB SRMS SRMS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
GNA13G protein subunit alpha 13. (377 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (383 aa)
PTGIRProstaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
ACTL8Actin like 8; Belongs to the actin family. (365 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (367 aa)
RAP1BUncharacterized protein. (184 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
LOC113901022Uncharacterized protein. (330 aa)
DHRSXDehydrogenase/reductase X-linked. (342 aa)
MYLK3Myosin light chain kinase 3. (786 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (636 aa)
TLNRD1Talin rod domain containing 1. (362 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1117 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
RASGRP2RAS guanyl releasing protein 2. (608 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (893 aa)
VWFVon Willebrand factor. (2810 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GP9Glycoprotein IX platelet. (175 aa)
MYL12AMyosin light chain 12A. (178 aa)
MYL12BMyosin light chain 12B. (171 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1179 aa)
LCP2Lymphocyte cytosolic protein 2. (532 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
A0A4W2CEF6Integrin beta; Belongs to the integrin beta chain family. (784 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (691 aa)
STIM1Stromal interaction molecule 1. (789 aa)
APBB1IPAmyloid beta precursor protein binding family B member 1 interacting protein. (712 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (968 aa)
FGGFibrinogen gamma chain. (443 aa)
FGAFibrinogen C-terminal domain-containing protein. (863 aa)
A0A4W2CL25Uncharacterized protein. (338 aa)
ZNF408Zinc finger protein 408. (731 aa)
DGCR6LUncharacterized protein. (269 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
RDH14Retinol dehydrogenase 14; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (336 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1226 aa)
GNASGNAS complex locus. (1004 aa)
PTGS1Prostaglandin-endoperoxide synthase 1. (635 aa)
MYLK2Myosin light chain kinase 2. (739 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1469 aa)
PLA2G4EPhospholipase A2. (860 aa)
MYLKMyosin light chain kinase. (2163 aa)
A0A4W2CZ07Phospholipase A2. (821 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
CPN2Carboxypeptidase N subunit 2. (548 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
GP5Glycoprotein V platelet. (539 aa)
PRKG2cGMP-dependent protein kinase. (747 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
TLN1Talin 1. (2539 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
TLN2Talin 2. (2542 aa)
A0A4W2DC91Uncharacterized protein. (241 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
TBXA2RThromboxane A2 receptor. (343 aa)
GNAI1G protein subunit alpha i1. (417 aa)
SYKTyrosine-protein kinase. (628 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1171 aa)
FERMT3Fermitin family member 3. (669 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
A0A4W2DSL7Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (627 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (401 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
P2RY12Purinergic receptor P2Y12. (342 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1356 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (730 aa)
FGBFibrinogen beta chain. (490 aa)
JMJD7Jumonji domain containing 7. (316 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ACTBActin beta. (375 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (303 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1253 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (756 aa)
A0A4W2E5U2LRRCT domain-containing protein. (706 aa)
PLA2G4APhospholipase A2. (749 aa)
ACTBL2Actin beta like 2. (376 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1218 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1197 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
RDH13Retinol dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (335 aa)
PLA2G4DPhospholipase A2. (808 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
LYNTyrosine-protein kinase. (491 aa)
F2Coagulation factor II, thrombin; Belongs to the peptidase S1 family. (631 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
FYNTyrosine-protein kinase. (537 aa)
PTK6Tyrosine-protein kinase. (450 aa)
PLA2G4FPhospholipase A2. (845 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (445 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
TBXAS1Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (580 aa)
LRRC15Leucine rich repeat containing 15. (584 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1083 aa)
PIK3R3Uncharacterized protein. (461 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
COL1A1Collagen type I alpha 1 chain. (1584 aa)
GNAI2G protein subunit alpha i2. (436 aa)
GNAQG protein subunit alpha q. (359 aa)
VAMP8Vesicle associated membrane protein 8. (100 aa)
RHOARas homolog family member A. (193 aa)
SRCTyrosine-protein kinase. (559 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
PIK3R2Uncharacterized protein. (724 aa)
COL1A2Collagen type I alpha 2 chain. (1364 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (199 aa)
SRMSTyrosine-protein kinase. (504 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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