(95 nodes) RIG-I-like receptor signaling pathway network (Bos indicus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113897811	Uncharacterized protein. (186 aa)
	LOC113897789	Uncharacterized protein. (195 aa)
	A0A4W2GUX8	Uncharacterized protein. (186 aa)
	LOC113897795	Uncharacterized protein. (189 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (669 aa)
	A0A4W2H902	Uncharacterized protein. (134 aa)
	A0A4W2HBP3	CARD_2 domain-containing protein. (65 aa)
	LOC113888606	Uncharacterized protein. (195 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (974 aa)
	LOC113896989	Uncharacterized protein. (186 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (485 aa)
	MAPK13	Mitogen-activated protein kinase. (455 aa)
	TRIM25	Tripartite motif containing 25. (631 aa)
	COIL	Coilin. (694 aa)
	ATG12	Uncharacterized protein. (266 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
	A0A4W2E7C9	TNF receptor-associated factor. (411 aa)
	NFKBIB	NFKB inhibitor beta. (357 aa)
	ISG15	ISG15 ubiquitin like modifier. (154 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
	TRIM47	Tripartite motif containing 47. (649 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (214 aa)
	LOC113897812	Uncharacterized protein. (186 aa)
	A0A4W2EMJ2	Uncharacterized protein. (195 aa)
	A0A4W2EMK8	Uncharacterized protein. (195 aa)
	A0A4W2EML2	Uncharacterized protein. (186 aa)
	A0A4W2EML3	Uncharacterized protein. (189 aa)
	A0A4W2EMM2	Uncharacterized protein. (187 aa)
	LOC113896984	Uncharacterized protein. (190 aa)
	A0A4W2EMP1	Uncharacterized protein. (195 aa)
	A0A4W2EMP5	Uncharacterized protein. (184 aa)
	A0A4W2EMW3	Uncharacterized protein. (194 aa)
	IFNK	Interferon kappa. (215 aa)
	CXCL10	C-X-C motif chemokine. (102 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (240 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1021 aa)
	TANK	TRAF family member associated NFKB activator. (481 aa)
	TMEM173	Transmembrane protein 173. (484 aa)
	FGFR1OP2	FGFR1 oncogene partner 2. (253 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	MAPK10	Mitogen-activated protein kinase. (425 aa)
	SIKE1	Suppressor of IKBKE 1. (207 aa)
	TRADD	TNFRSF1A associated via death domain. (312 aa)
	LOC113888607	Uncharacterized protein. (189 aa)
	DHX58	DExH-box helicase 58. (680 aa)
	A0A4W2BK72	Uncharacterized protein. (172 aa)
	A0A4W2BMI7	Uncharacterized protein. (195 aa)
	LOC113888605	Uncharacterized protein. (195 aa)
	TKFC	Triokinase and FMN cyclase. (594 aa)
	RNF125	Ring finger protein 125. (234 aa)
	RNF135	Ring finger protein 135. (445 aa)
	AZI2	5-azacytidine induced 2. (393 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
	NLRX1	NLR family member X1. (990 aa)
	LOC113888611	Uncharacterized protein. (195 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	A0A4W2C218	Uncharacterized protein. (627 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1507 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (209 aa)
	MAPK12	Mitogen-activated protein kinase. (367 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa)
	TRIM65	Tripartite motif containing 65. (548 aa)
	IRF3	Interferon regulatory factor 3. (417 aa)
	A0A4W2CR26	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
	MAVS	Mitochondrial antiviral signaling protein. (615 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	A0A4W2CWS2	Uncharacterized protein. (154 aa)
	A0A4W2CWU5	Uncharacterized protein. (190 aa)
	A0A4W2CWV7	Uncharacterized protein. (189 aa)
	A0A4W2CX00	Uncharacterized protein. (189 aa)
	A0A4W2CX03	Uncharacterized protein. (254 aa)
	LOC113896968	Uncharacterized protein. (195 aa)
	LOC113896981	Uncharacterized protein. (193 aa)
	A0A4W2D155	Uncharacterized protein. (153 aa)
	LOC113897798	Uncharacterized protein. (195 aa)
	DDX58	DExD/H-box helicase 58. (941 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	A0A4W2DGC7	Uncharacterized protein. (186 aa)
	A0A4W2DJH4	Uncharacterized protein. (189 aa)
	A0A4W2DJH9	Uncharacterized protein. (195 aa)
	DDX3X	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (645 aa)
	A0A4W2DQ16	Uncharacterized protein; Belongs to the DEAD box helicase family. (693 aa)
	A0A4W2DQU8	Uncharacterized protein. (300 aa)
	A0A4W2DQY6	C-X-C motif chemokine. (138 aa)
	IRF7	Interferon regulatory factor 7. (480 aa)
	TBKBP1	TBK1 binding protein 1. (673 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2BK72	A0A4W2DGC7	A0A4W2BK72	A0A4W2DGC7	Uncharacterized protein.	Uncharacterized protein.	0.409
A0A4W2BK72	A0A4W2EML2	A0A4W2BK72	A0A4W2EML2	Uncharacterized protein.	Uncharacterized protein.	0.406
A0A4W2BK72	IRF3	A0A4W2BK72	A0A4W2CMV4	Uncharacterized protein.	Interferon regulatory factor 3.	0.603
A0A4W2BK72	IRF7	A0A4W2BK72	A0A4W2DTD7	Uncharacterized protein.	Interferon regulatory factor 7.	0.542
A0A4W2BK72	LOC113896989	A0A4W2BK72	A0A4W2IDD8	Uncharacterized protein.	Uncharacterized protein.	0.412
A0A4W2BK72	LOC113897811	A0A4W2BK72	A0A4W2GSY4	Uncharacterized protein.	Uncharacterized protein.	0.400
A0A4W2BK72	NFKB1	A0A4W2BK72	A0A4W2I6Y9	Uncharacterized protein.	Nuclear factor kappa B subunit 1.	0.539
A0A4W2C218	A0A4W2HBP3	A0A4W2C218	A0A4W2HBP3	Uncharacterized protein.	CARD_2 domain-containing protein.	0.548
A0A4W2C218	DDX58	A0A4W2C218	A0A4W2D270	Uncharacterized protein.	DExD/H-box helicase 58.	0.946
A0A4W2C218	DHX58	A0A4W2C218	A0A4W2IRR5	Uncharacterized protein.	DExH-box helicase 58.	0.444
A0A4W2C218	IFIH1	A0A4W2C218	A0A4W2EX35	Uncharacterized protein.	Interferon induced with helicase C domain 1.	0.745
A0A4W2C218	IRF3	A0A4W2C218	A0A4W2CMV4	Uncharacterized protein.	Interferon regulatory factor 3.	0.641
A0A4W2C218	IRF7	A0A4W2C218	A0A4W2DTD7	Uncharacterized protein.	Interferon regulatory factor 7.	0.546
A0A4W2C218	ISG15	A0A4W2C218	A0A4W2EEE2	Uncharacterized protein.	ISG15 ubiquitin like modifier.	0.699
A0A4W2C218	MAVS	A0A4W2C218	A0A4W2CTE1	Uncharacterized protein.	Mitochondrial antiviral signaling protein.	0.548
A0A4W2C218	RNF125	A0A4W2C218	A0A4W2BQW3	Uncharacterized protein.	Ring finger protein 125.	0.440
A0A4W2C218	TBK1	A0A4W2C218	A0A4W2CVJ0	Uncharacterized protein.	TANK binding kinase 1.	0.510
A0A4W2C218	TRAF3	A0A4W2C218	A0A4W2FZ99	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.460
A0A4W2CR26	A0A4W2EML2	A0A4W2CR26	A0A4W2EML2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Uncharacterized protein.	0.507
A0A4W2CR26	A0A4W2HBP3	A0A4W2CR26	A0A4W2HBP3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	CARD_2 domain-containing protein.	0.931

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