STRINGSTRING
CARD9 CARD9 CASP8 CASP8 PYCARD PYCARD NFKBIA NFKBIA EGR3 EGR3 MAPK3 MAPK3 NFKB1 NFKB1 JUN JUN CCL17 CCL17 PAK1 PAK1 CLEC4G CLEC4G MAPKAPK2 MAPKAPK2 HRAS HRAS IRF9 IRF9 RRAS RRAS NLRP3 NLRP3 PTPN11 PTPN11 PTGS2 PTGS2 NFATC3 NFATC3 IRF1 IRF1 MAPK10 MAPK10 LOC113876456 LOC113876456 CCL22 CCL22 RELA RELA CLEC4D CLEC4D PIK3R2 PIK3R2 AKT1 AKT1 CLEC1A CLEC1A SRC SRC CLEC1B CLEC1B RHOA RHOA IL2 IL2 CHUK CHUK PLK3 PLK3 PLCG2 PLCG2 MAPK9 MAPK9 PPP3CA PPP3CA IL6 IL6 PIK3R3 PIK3R3 TMEM52B TMEM52B IL12A IL12A CALML4 CALML4 BCL10 BCL10 RELB RELB LOC113876428 LOC113876428 IL1B IL1B A0A4W2EIV4 A0A4W2EIV4 CLEC6A CLEC6A REM1 REM1 A0A4W2EHH7 A0A4W2EHH7 TNF TNF AKT3 AKT3 ARHGEF12 ARHGEF12 MAP3K14 MAP3K14 STAT1 STAT1 IL12B IL12B CYLD CYLD PIK3CB PIK3CB A0A4W2DXS4 A0A4W2DXS4 KRAS KRAS MAPK13 MAPK13 PPP3CC PPP3CC EGR2 EGR2 ERAS ERAS PIK3CA PIK3CA PRKCD PRKCD CBLB CBLB NRAS NRAS SYK SYK NFATC4 NFATC4 MRAS MRAS ITPR2 ITPR2 A0A4W2D4V5 A0A4W2D4V5 MAPK8 MAPK8 CSDE1 CSDE1 CALM1 CALM1 CD209 CD209 EFCAB13 EFCAB13 RRAD RRAD CLEC4A CLEC4A MDM2 MDM2 IL23A IL23A PIK3CD PIK3CD MAPK1 MAPK1 NFATC2 NFATC2 STAT2 STAT2 RRAS2 RRAS2 BCL3 BCL3 IKBKE IKBKE A0A4W2CJ69 A0A4W2CJ69 A0A4W2CJ16 A0A4W2CJ16 AKT2 AKT2 CEACAM16 CEACAM16 MAPK12 MAPK12 EFCAB3 EFCAB3 GEM GEM CLEC4E CLEC4E CLEC9A CLEC9A CLEC7A CLEC7A PIK3R1 PIK3R1 KSR1 KSR1 NFKB2 NFKB2 MAPK11 MAPK11 MALT1 MALT1 ITPR3 ITPR3 IKBKB IKBKB PPP3CB PPP3CB RAF1 RAF1 LSP1 LSP1 ITPR1 ITPR1 IL17D IL17D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CARD9Caspase recruitment domain family member 9. (538 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (485 aa)
PYCARDPYD and CARD domain containing. (195 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
EGR3Early growth response 3. (387 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
NFKB1Nuclear factor kappa B subunit 1. (974 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
CCL17C-C motif chemokine. (102 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
CLEC4GC-type lectin domain family 4 member G. (290 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (409 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
IRF9Interferon regulatory factor 9. (439 aa)
RRASRAS related. (218 aa)
NLRP3NLR family pyrin domain containing 3. (1031 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
NFATC3Nuclear factor of activated T cells 3. (1073 aa)
IRF1Interferon regulatory factor. (322 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
LOC113876456Uncharacterized protein. (436 aa)
CCL22C-C motif chemokine. (93 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CLEC4DC-type lectin domain family 4 member D. (213 aa)
PIK3R2Uncharacterized protein. (724 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
CLEC1AC-type lectin domain family 1 member A. (278 aa)
SRCTyrosine-protein kinase. (559 aa)
CLEC1BC-type lectin domain family 1 member B. (226 aa)
RHOARas homolog family member A. (193 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
IL6Interleukin 6. (208 aa)
PIK3R3Uncharacterized protein. (461 aa)
TMEM52BTransmembrane protein 52B. (182 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (240 aa)
CALML4Calmodulin like 4. (153 aa)
BCL10BCL10 immune signaling adaptor. (230 aa)
RELBRELB proto-oncogene, NF-kB subunit. (647 aa)
LOC113876428Uncharacterized protein. (441 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
A0A4W2EIV4EF-hand domain-containing protein; Belongs to the calmodulin family. (87 aa)
CLEC6AC-type lectin domain containing 6A. (206 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
A0A4W2EHH7Uncharacterized protein. (91 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (953 aa)
STAT1Signal transducer and activator of transcription. (821 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
A0A4W2DXS4RING-type domain-containing protein. (131 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
PPP3CCSerine/threonine-protein phosphatase. (531 aa)
EGR2Early growth response 2. (485 aa)
ERASES cell expressed Ras. (185 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
CBLBCbl proto-oncogene B. (939 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SYKTyrosine-protein kinase. (628 aa)
NFATC4Nuclear factor of activated T cells 4. (979 aa)
MRASMuscle RAS oncogene homolog. (259 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
A0A4W2D4V5Uncharacterized protein. (607 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CSDE1Cold shock domain containing E1. (844 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (365 aa)
CD209C-type lectin domain-containing protein. (259 aa)
EFCAB13EF-hand calcium binding domain 13. (762 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
CLEC4AC-type lectin domain family 4 member A. (237 aa)
MDM2MDM2 proto-oncogene. (689 aa)
IL23AInterleukin 23 subunit alpha. (192 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
NFATC2Nuclear factor of activated T cells 2. (914 aa)
STAT2Signal transducer and activator of transcription. (857 aa)
RRAS2RAS related 2. (204 aa)
BCL3BCL3 transcription coactivator. (454 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa)
A0A4W2CJ69Ig-like domain-containing protein. (312 aa)
A0A4W2CJ16Uncharacterized protein. (252 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
CEACAM16Carcinoembryonic antigen related cell adhesion molecule 16. (424 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
EFCAB3EF-hand calcium binding domain 3. (491 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (311 aa)
CLEC4EC-type lectin domain family 4 member E. (211 aa)
CLEC9AC-type lectin domain containing 9A. (283 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
KSR1Kinase suppressor of ras 1. (928 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MALT1MALT1 paracaspase. (850 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
LSP1Lymphocyte specific protein 1. (400 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
IL17DInterleukin 17D. (197 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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