STRINGSTRING
MAP2K2 MAP2K2 LOC113888607 LOC113888607 LOC113896989 LOC113896989 SOS1 SOS1 NCR1 NCR1 MAPK3 MAPK3 PRKCB PRKCB PAK1 PAK1 LCK LCK SH3BP2 SH3BP2 HRAS HRAS A0A4W2GYG4 A0A4W2GYG4 PTPN11 PTPN11 LOC113897795 LOC113897795 LOC113897811 LOC113897811 PRKCA PRKCA SRMS SRMS CD244 CD244 NCR3 NCR3 PIK3R2 PIK3R2 A0A4W2FN91 A0A4W2FN91 VAV1 VAV1 SHC1 SHC1 PLCG2 PLCG2 CD247 CD247 ITGB2 ITGB2 PPP3CA PPP3CA CD48 CD48 RAC2 RAC2 IFNGR2 IFNGR2 PIK3R3 PIK3R3 A0A4W2EX23 A0A4W2EX23 A0A4W2EVF1 A0A4W2EVF1 A0A4W2EUW0 A0A4W2EUW0 TNFSF10 TNFSF10 PTK2B PTK2B CSF2 CSF2 VAV3 VAV3 BRAF BRAF PLCG1 PLCG1 A0A4W2EMM2 A0A4W2EMM2 A0A4W2EML3 A0A4W2EML3 A0A4W2EML2 A0A4W2EML2 ZAP70 ZAP70 LOC113897812 LOC113897812 PTK6 PTK6 LOC113875952 LOC113875952 A0A4W2EJL1 A0A4W2EJL1 A0A4W2EJK5 A0A4W2EJK5 FYN FYN A0A4W2EIH2 A0A4W2EIH2 LOC113898569 LOC113898569 A0A4W2EI98 A0A4W2EI98 LOC113898520 LOC113898520 IFNG IFNG TNF TNF A0A4W2EF70 A0A4W2EF70 A0A4W2EEI7 A0A4W2EEI7 SOS2 SOS2 PRKCG PRKCG FASLG FASLG A0A4W2EA01 A0A4W2EA01 A0A4W2E3N3 A0A4W2E3N3 PIK3CB PIK3CB KRAS KRAS PRF1 PRF1 VAV2 VAV2 A0A4W2DX14 A0A4W2DX14 A0A4W2DVL0 A0A4W2DVL0 A0A4W2DVJ7 A0A4W2DVJ7 PPP3CC PPP3CC A0A4W2DSK5 A0A4W2DSK5 ERAS ERAS PIK3CA PIK3CA NRAS NRAS A0A4W2DNG0 A0A4W2DNG0 A0A4W2DNF6 A0A4W2DNF6 SYK SYK SHC3 SHC3 ITGAL ITGAL A0A4W2DLK7 A0A4W2DLK7 SH2D1B SH2D1B A0A4W2DJH4 A0A4W2DJH4 IFNAR1 IFNAR1 IFNAR2 IFNAR2 A0A4W2DGC7 A0A4W2DGC7 A0A4W2DG45 A0A4W2DG45 LOC113898570 LOC113898570 A0A4W2DAT2 A0A4W2DAT2 A0A4W2DAT0 A0A4W2DAT0 KLRK1 KLRK1 A0A4W2DAN0 A0A4W2DAN0 A0A4W2D4V5 A0A4W2D4V5 MAP2K1 MAP2K1 CSDE1 CSDE1 A0A4W2D326 A0A4W2D326 A0A4W2D155 A0A4W2D155 LOC113898559 LOC113898559 A0A4W2CZ80 A0A4W2CZ80 A0A4W2CZ31 A0A4W2CZ31 A0A4W2CX00 A0A4W2CX00 A0A4W2CWV7 A0A4W2CWV7 IFNGR1 IFNGR1 A0A4W2CWS2 A0A4W2CWS2 TYROBP TYROBP HCST HCST PIK3CD PIK3CD PTPN6 PTPN6 MAPK1 MAPK1 NFATC2 NFATC2 SHC4 SHC4 A0A4W2CM92 A0A4W2CM92 A0A4W2CM05 A0A4W2CM05 BID BID GRB2 GRB2 LCP2 LCP2 KLRG1 KLRG1 LOC113879826 LOC113879826 LOC113879914 LOC113879914 A0A4W2CBG8 A0A4W2CBG8 GZMB GZMB A0A4W2CAS0 A0A4W2CAS0 A0A4W2CAP7 A0A4W2CAP7 A0A4W2CAP3 A0A4W2CAP3 RAC1 RAC1 A0A4W2C9G1 A0A4W2C9G1 PIK3R1 PIK3R1 RAC3 RAC3 A0A4W2C518 A0A4W2C518 FAS FAS A0A4W2C1R6 A0A4W2C1R6 CASP3 CASP3 A0A4W2BWE6 A0A4W2BWE6 A0A4W2BVW3 A0A4W2BVW3 PPP3CB PPP3CB LAT LAT A0A4W2BTN2 A0A4W2BTN2 A0A4W2BTN1 A0A4W2BTN1 RAF1 RAF1 A0A4W2BK72 A0A4W2BK72
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
LOC113888607Uncharacterized protein. (189 aa)
LOC113896989Uncharacterized protein. (186 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
NCR1Natural cytotoxicity triggering receptor 1. (308 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
LCKTyrosine-protein kinase. (509 aa)
SH3BP2SH3 domain binding protein 2. (618 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
LOC113897795Uncharacterized protein. (189 aa)
LOC113897811Uncharacterized protein. (186 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
SRMSTyrosine-protein kinase. (504 aa)
CD244Ig-like domain-containing protein. (423 aa)
NCR3Natural cytotoxicity triggering receptor 3. (178 aa)
PIK3R2Uncharacterized protein. (724 aa)
A0A4W2FN91C-type lectin domain-containing protein. (237 aa)
VAV1Vav guanine nucleotide exchange factor 1. (872 aa)
SHC1SHC adaptor protein 1. (584 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
CD247CD247 molecule. (166 aa)
ITGB2Integrin beta. (769 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CD48Ig-like domain-containing protein. (239 aa)
RAC2Rac family small GTPase 2. (209 aa)
IFNGR2Interferon gamma receptor 2. (376 aa)
PIK3R3Uncharacterized protein. (461 aa)
A0A4W2EX23C-type lectin domain-containing protein. (277 aa)
A0A4W2EVF1Uncharacterized protein. (308 aa)
A0A4W2EUW0Uncharacterized protein. (559 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (287 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1008 aa)
CSF2Colony stimulating factor 2. (143 aa)
VAV3Vav guanine nucleotide exchange factor 3. (977 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
A0A4W2EMM2Uncharacterized protein. (187 aa)
A0A4W2EML3Uncharacterized protein. (189 aa)
A0A4W2EML2Uncharacterized protein. (186 aa)
ZAP70Tyrosine-protein kinase. (617 aa)
LOC113897812Uncharacterized protein. (186 aa)
PTK6Tyrosine-protein kinase. (450 aa)
LOC113875952Ig-like domain-containing protein. (434 aa)
A0A4W2EJL1MHC_I-like_Ag-recog domain-containing protein. (315 aa)
A0A4W2EJK5MHC_I-like_Ag-recog domain-containing protein. (251 aa)
FYNTyrosine-protein kinase. (537 aa)
A0A4W2EIH2ICAM_N domain-containing protein. (251 aa)
LOC113898569MHC_I-like_Ag-recog domain-containing protein. (245 aa)
A0A4W2EI98MHC_I-like_Ag-recog domain-containing protein. (290 aa)
LOC113898520MHC_I-like_Ag-recog domain-containing protein. (297 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
A0A4W2EF70Ig-like domain-containing protein. (380 aa)
A0A4W2EEI7MHC_I-like_Ag-recog domain-containing protein. (273 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (771 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (277 aa)
A0A4W2EA01Uncharacterized protein. (48 aa)
A0A4W2E3N3IGc1 domain-containing protein. (373 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PRF1Perforin 1. (559 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
A0A4W2DX14Ig-like domain-containing protein. (160 aa)
A0A4W2DVL0C-type lectin domain-containing protein. (243 aa)
A0A4W2DVJ7Ig-like domain-containing protein. (375 aa)
PPP3CCSerine/threonine-protein phosphatase. (531 aa)
A0A4W2DSK5TNFR-Cys domain-containing protein. (251 aa)
ERASES cell expressed Ras. (185 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
A0A4W2DNG0Ig-like domain-containing protein. (591 aa)
A0A4W2DNF6Ig-like domain-containing protein. (488 aa)
SYKTyrosine-protein kinase. (628 aa)
SHC3SHC adaptor protein 3. (587 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1165 aa)
A0A4W2DLK7Uncharacterized protein. (250 aa)
SH2D1BSH2 domain containing 1B. (133 aa)
A0A4W2DJH4Uncharacterized protein. (189 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (561 aa)
IFNAR2Uncharacterized protein. (530 aa)
A0A4W2DGC7Uncharacterized protein. (186 aa)
A0A4W2DG45C-type lectin domain-containing protein. (235 aa)
LOC113898570MHC_I-like_Ag-recog domain-containing protein. (242 aa)
A0A4W2DAT2C-type lectin domain-containing protein. (197 aa)
A0A4W2DAT0C-type lectin domain-containing protein. (226 aa)
KLRK1Killer cell lectin like receptor K1. (215 aa)
A0A4W2DAN0C-type lectin domain-containing protein. (180 aa)
A0A4W2D4V5Uncharacterized protein. (607 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
CSDE1Cold shock domain containing E1. (844 aa)
A0A4W2D326Uncharacterized protein. (165 aa)
A0A4W2D155Uncharacterized protein. (153 aa)
LOC113898559Uncharacterized protein. (154 aa)
A0A4W2CZ80MHC_I-like_Ag-recog domain-containing protein. (242 aa)
A0A4W2CZ31MHC_I-like_Ag-recog domain-containing protein. (237 aa)
A0A4W2CX00Uncharacterized protein. (189 aa)
A0A4W2CWV7Uncharacterized protein. (189 aa)
IFNGR1Interferon gamma receptor 1. (500 aa)
A0A4W2CWS2Uncharacterized protein. (154 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (159 aa)
HCSTHematopoietic cell signal transducer. (93 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
NFATC2Nuclear factor of activated T cells 2. (914 aa)
SHC4SHC adaptor protein 4. (630 aa)
A0A4W2CM92Uncharacterized protein. (505 aa)
A0A4W2CM05Ig-like domain-containing protein. (399 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
LCP2Lymphocyte cytosolic protein 2. (532 aa)
KLRG1Killer cell lectin like receptor G1. (190 aa)
LOC113879826Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
LOC113879914Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (255 aa)
A0A4W2CBG8Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (254 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (246 aa)
A0A4W2CAS0Ig-like domain-containing protein. (223 aa)
A0A4W2CAP7Ig-like domain-containing protein. (213 aa)
A0A4W2CAP3Ig-like domain-containing protein. (182 aa)
RAC1Rac family small GTPase 1. (257 aa)
A0A4W2C9G1ICAM_N domain-containing protein. (351 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RAC3Rac family small GTPase 3. (258 aa)
A0A4W2C518Ig-like domain-containing protein. (367 aa)
FASFas cell surface death receptor. (323 aa)
A0A4W2C1R6MHC_I-like_Ag-recog domain-containing protein. (298 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
A0A4W2BWE6Ig-like domain-containing protein. (204 aa)
A0A4W2BVW3Ig-like domain-containing protein. (218 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
LATUncharacterized protein. (295 aa)
A0A4W2BTN2Ig-like domain-containing protein. (130 aa)
A0A4W2BTN1Uncharacterized protein. (508 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
A0A4W2BK72Uncharacterized protein. (172 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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