STRINGSTRING
MMP12 MMP12 CHUK CHUK MAPK9 MAPK9 IL6 IL6 A0A4W2EXS1 A0A4W2EXS1 LOC113890428 LOC113890428 S100A8 S100A8 CXCL8 CXCL8 CXCL10 CXCL10 IL4 IL4 CSF2 CSF2 IL1B IL1B LCN2 LCN2 IFNG IFNG TNF TNF TNFAIP3 TNFAIP3 FOSB FOSB A0A4W2E7C9 A0A4W2E7C9 IL17RA IL17RA MAPK15 MAPK15 MAPK13 MAPK13 A0A4W2DUN4 A0A4W2DUN4 A0A4W2DUF4 A0A4W2DUF4 LOC113894385 LOC113894385 IL17F IL17F CCL2 CCL2 TRAF4 TRAF4 MAPK4 MAPK4 A0A4W2DQY6 A0A4W2DQY6 A0A4W2DPG3 A0A4W2DPG3 IL5 IL5 HSP90B1 HSP90B1 FOS FOS A0A4W2DHD6 A0A4W2DHD6 A0A4W2DGD3 A0A4W2DGD3 IL17B IL17B S100A9 S100A9 CCL20 CCL20 MAPK8 MAPK8 A0A4W2D326 A0A4W2D326 ELAVL1 ELAVL1 IL25 IL25 A0A4W2CZ95 A0A4W2CZ95 GSK3B GSK3B TBK1 TBK1 A0A4W2CR26 A0A4W2CR26 IL17C IL17C MAPK1 MAPK1 MAPK7 MAPK7 IKBKE IKBKE MMP3 MMP3 MAP3K7 MAP3K7 MAPK12 MAPK12 FADD FADD TRAF3IP2 TRAF3IP2 FOSL1 FOSL1 ANAPC5 ANAPC5 HSP90AA1 HSP90AA1 A0A4W2C633 A0A4W2C633 TRAF5 TRAF5 MMP13 MMP13 A0A4W2C285 A0A4W2C285 A0A4W2C1U6 A0A4W2C1U6 IL17RB IL17RB CASP3 CASP3 CSF3 CSF3 MAPK11 MAPK11 A0A4W2C006 A0A4W2C006 A0A4W2BZ83 A0A4W2BZ83 IKBKB IKBKB TRAF2 TRAF2 IL17RC IL17RC IL17RE IL17RE A0A4W2BM87 A0A4W2BM87 IL17D IL17D USP25 USP25 PTGS2 PTGS2 SRSF1 SRSF1 IL13 IL13 MAPK6 MAPK6 CCL17 CCL17 JUN JUN NFKB1 NFKB1 MAPK3 MAPK3 IL17A IL17A CXCL6 CXCL6 NFKBIA NFKBIA CASP8 CASP8 TRADD TRADD CEBPB CEBPB TAB2 TAB2 CCL11 CCL11 MAPK10 MAPK10 MMP9 MMP9 A0A4W2G4K5 A0A4W2G4K5 RELA RELA TRAF3 TRAF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP12Matrix metallopeptidase 12. (471 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
IL6Interleukin 6. (208 aa)
A0A4W2EXS1Protein S100; Belongs to the S-100 family. (101 aa)
LOC113890428Protein S100; Belongs to the S-100 family. (101 aa)
S100A8S100 calcium binding protein A8; Belongs to the S-100 family. (81 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CXCL10C-X-C motif chemokine. (102 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (135 aa)
CSF2Colony stimulating factor 2. (143 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
LCN2Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (200 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
TNFAIP3TNF alpha induced protein 3. (780 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (341 aa)
A0A4W2E7C9TNF receptor-associated factor. (411 aa)
IL17RAInterleukin 17 receptor A. (832 aa)
MAPK15Mitogen-activated protein kinase. (657 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
A0A4W2DUN4DEFSN domain-containing protein. (64 aa)
A0A4W2DUF4ZnMc domain-containing protein. (472 aa)
LOC113894385C-X-C motif chemokine. (104 aa)
IL17FInterleukin 17F. (170 aa)
CCL2C-C motif chemokine. (99 aa)
TRAF4TNF receptor associated factor 4. (661 aa)
MAPK4Mitogen-activated protein kinase 4. (588 aa)
A0A4W2DQY6C-X-C motif chemokine. (138 aa)
A0A4W2DPG3DEFSN domain-containing protein. (62 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
HSP90B1Heat shock protein 90 beta family member 1. (808 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
A0A4W2DHD6Protein S100; Belongs to the S-100 family. (128 aa)
A0A4W2DGD3Uncharacterized protein. (472 aa)
IL17BInterleukin 17B. (229 aa)
S100A9S100 calcium binding protein A9; Belongs to the S-100 family. (156 aa)
CCL20C-C motif chemokine. (96 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
A0A4W2D326Uncharacterized protein. (165 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (347 aa)
IL25Interleukin 25. (169 aa)
A0A4W2CZ95Uncharacterized protein. (506 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
TBK1TANK binding kinase 1. (729 aa)
A0A4W2CR26TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
IL17CInterleukin 17C. (197 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (781 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (209 aa)
TRAF3IP2TRAF3 interacting protein 2. (596 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (774 aa)
A0A4W2C633Uncharacterized protein. (4359 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
MMP13Matrix metallopeptidase 13. (471 aa)
A0A4W2C285ZnMc domain-containing protein. (469 aa)
A0A4W2C1U6DEFSN domain-containing protein. (58 aa)
IL17RBInterleukin 17 receptor B. (499 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
CSF3Colony stimulating factor 3. (215 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
A0A4W2C006DEFSN domain-containing protein. (64 aa)
A0A4W2BZ83DEFSN domain-containing protein. (64 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
IL17RCInterleukin 17 receptor C. (716 aa)
IL17REInterleukin 17 receptor E. (725 aa)
A0A4W2BM87DEFSN domain-containing protein. (64 aa)
IL17DInterleukin 17D. (197 aa)
USP25Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. (1152 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
SRSF1Uncharacterized protein. (248 aa)
IL13Interleukin 13. (146 aa)
MAPK6Mitogen-activated protein kinase 6. (722 aa)
CCL17C-C motif chemokine. (102 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
NFKB1Nuclear factor kappa B subunit 1. (974 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
IL17AInterleukin 17A. (153 aa)
CXCL6C-X-C motif chemokine. (112 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (485 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
CEBPBCCAAT/enhancer-binding protein. (348 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
CCL11C-C motif chemokine. (97 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
MMP9Matrix metallopeptidase 9. (712 aa)
A0A4W2G4K5DEFSN domain-containing protein. (60 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
Server load: low (34%) [HD]