STRINGSTRING
MAPK1 MAPK1 RORA RORA IL23A IL23A IL6ST IL6ST MTOR MTOR IFNGR1 IFNGR1 GATA3 GATA3 DUSP15 DUSP15 A0A4W2CZ95 A0A4W2CZ95 A0A4W2D056 A0A4W2D056 A0A4W2D095 A0A4W2D095 A0A4W2D0D6 A0A4W2D0D6 A0A4W2D0E0 A0A4W2D0E0 A0A4W2D0G3 A0A4W2D0G3 A0A4W2D0I4 A0A4W2D0I4 A0A4W2D2L8 A0A4W2D2L8 A0A4W2D2R2 A0A4W2D2R2 A0A4W2D2S0 A0A4W2D2S0 A0A4W2D2S8 A0A4W2D2S8 A0A4W2D2T1 A0A4W2D2T1 A0A4W2D2W9 A0A4W2D2W9 MAPK8 MAPK8 A0A4W2D520 A0A4W2D520 A0A4W2D547 A0A4W2D547 A0A4W2D552 A0A4W2D552 A0A4W2D597 A0A4W2D597 A0A4W2D5F7 A0A4W2D5F7 A0A4W2D5G0 A0A4W2D5G0 A0A4W2D5H8 A0A4W2D5H8 A0A4W2D5P0 A0A4W2D5P0 A0A4W2D704 A0A4W2D704 A0A4W2D709 A0A4W2D709 A0A4W2D724 A0A4W2D724 A0A4W2D760 A0A4W2D760 A0A4W2D781 A0A4W2D781 A0A4W2D7C1 A0A4W2D7C1 STAT6 STAT6 IL6R IL6R TYK2 TYK2 IL2RB IL2RB A0A4W2DK77 A0A4W2DK77 A0A4W2DK85 A0A4W2DK85 FOS FOS IL27RA IL27RA RXRG RXRG A0A4W2DMB6 A0A4W2DMB6 IL23R IL23R TRBV24-1 TRBV24-1 A0A4W2DMM0 A0A4W2DMM0 SMAD4 SMAD4 A0A4W2DRK4 A0A4W2DRK4 HLA-DMA HLA-DMA IL17F IL17F PPP3CC PPP3CC MAPK13 MAPK13 A0A4W2DVU2 A0A4W2DVU2 IL12RB1 IL12RB1 IL2RG IL2RG LOC113881774 LOC113881774 STAT1 STAT1 PRKCQ PRKCQ TGFBR2 TGFBR2 STAT3 STAT3 NFKBIB NFKBIB IL2RA IL2RA STAT5A STAT5A A0A4W2EDY1 A0A4W2EDY1 IL1R1 IL1R1 IFNG IFNG IL1B IL1B ZAP70 ZAP70 PLCG1 PLCG1 A0A4W2EPY6 A0A4W2EPY6 A0A4W2EQ07 A0A4W2EQ07 A0A4W2EQ96 A0A4W2EQ96 A0A4W2EQA0 A0A4W2EQA0 A0A4W2EQB9 A0A4W2EQB9 A0A4W2EQG3 A0A4W2EQG3 A0A4W2EQH2 A0A4W2EQH2 A0A4W2ERF0 A0A4W2ERF0 A0A4W2ERG5 A0A4W2ERG5 A0A4W2ERJ1 A0A4W2ERJ1 A0A4W2ERJ9 A0A4W2ERJ9 A0A4W2ERN6 A0A4W2ERN6 A0A4W2ERP9 A0A4W2ERP9 A0A4W2ES23 A0A4W2ES23 IL4 IL4 A0A4W2ES53 A0A4W2ES53 A0A4W2ES87 A0A4W2ES87 SMAD3 SMAD3 A0A4W2EX93 A0A4W2EX93 JAK3 JAK3 IL6 IL6 IFNGR2 IFNGR2 PPP3CA PPP3CA RUNX1 RUNX1 CD247 CD247 MAPK9 MAPK9 CHUK CHUK IL2 IL2 HLA-DOA HLA-DOA RELA RELA MAPK10 MAPK10 IL21R IL21R JAK1 JAK1 NFATC3 NFATC3 IL1RAP IL1RAP RORC RORC IL22 IL22 HIF1A HIF1A FOXP3 FOXP3 LCK LCK RXRB RXRB LOC113881562 LOC113881562 JAK2 JAK2 JUN JUN NFKB1 NFKB1 A0A4W2I9H2 A0A4W2I9H2 A0A4W2I9W6 A0A4W2I9W6 MAPK3 MAPK3 IL17A IL17A NFKBIA NFKBIA IL17D IL17D IRF4 IRF4 IL4R IL4R RXRA RXRA SMAD2 SMAD2 LAT LAT CD3E CD3E PPP3CB PPP3CB IKBKB IKBKB RARA RARA CD3D CD3D A0A4W2BXT5 A0A4W2BXT5 TBX21 TBX21 HLA-DQB1 HLA-DQB1 HLA-DRA HLA-DRA IL21 IL21 MAPK11 MAPK11 HLA-DOB HLA-DOB A0A4W2C1X2 A0A4W2C1X2 HSP90AA1 HSP90AA1 STAT5B STAT5B MAPK12 MAPK12 A0A4W2CFU3 A0A4W2CFU3 TGFB1 TGFB1 TGFBR1 TGFBR1 NFATC2 NFATC2 CD4 CD4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase. (634 aa)
RORARAR related orphan receptor A. (527 aa)
IL23AInterleukin 23 subunit alpha. (192 aa)
IL6STInterleukin 6 signal transducer. (935 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
IFNGR1Interferon gamma receptor 1. (500 aa)
GATA3GATA binding protein 3. (467 aa)
DUSP15Uncharacterized protein. (628 aa)
A0A4W2CZ95Uncharacterized protein. (506 aa)
A0A4W2D056Ig-like domain-containing protein. (153 aa)
A0A4W2D095Ig-like domain-containing protein. (143 aa)
A0A4W2D0D6Ig-like domain-containing protein. (177 aa)
A0A4W2D0E0Ig-like domain-containing protein. (136 aa)
A0A4W2D0G3Ig-like domain-containing protein. (151 aa)
A0A4W2D0I4Ig-like domain-containing protein. (112 aa)
A0A4W2D2L8Ig-like domain-containing protein. (147 aa)
A0A4W2D2R2Ig-like domain-containing protein. (118 aa)
A0A4W2D2S0Ig-like domain-containing protein. (174 aa)
A0A4W2D2S8Ig-like domain-containing protein. (127 aa)
A0A4W2D2T1Ig-like domain-containing protein. (127 aa)
A0A4W2D2W9Ig-like domain-containing protein. (261 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
A0A4W2D520Ig-like domain-containing protein. (202 aa)
A0A4W2D547Ig-like domain-containing protein. (146 aa)
A0A4W2D552Ig-like domain-containing protein. (153 aa)
A0A4W2D597Ig-like domain-containing protein. (112 aa)
A0A4W2D5F7Ig-like domain-containing protein. (182 aa)
A0A4W2D5G0Ig-like domain-containing protein. (106 aa)
A0A4W2D5H8Ig-like domain-containing protein. (237 aa)
A0A4W2D5P0DUF1968 domain-containing protein. (225 aa)
A0A4W2D704Ig-like domain-containing protein. (150 aa)
A0A4W2D709Ig-like domain-containing protein. (165 aa)
A0A4W2D724Ig-like domain-containing protein. (177 aa)
A0A4W2D760Ig-like domain-containing protein. (128 aa)
A0A4W2D781Ig-like domain-containing protein. (137 aa)
A0A4W2D7C1Ig-like domain-containing protein. (127 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
IL6RInterleukin 6 receptor. (464 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
IL2RBInterleukin 2 receptor subunit beta. (659 aa)
A0A4W2DK77Ig-like domain-containing protein. (193 aa)
A0A4W2DK85Ig-like domain-containing protein. (111 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IL27RAInterleukin 27 receptor subunit alpha. (614 aa)
RXRGRetinoid X receptor gamma. (463 aa)
A0A4W2DMB6Ig-like domain-containing protein. (172 aa)
IL23RInterleukin 23 receptor. (630 aa)
TRBV24-1T cell receptor beta variable 24-1. (97 aa)
A0A4W2DMM0IGv domain-containing protein. (177 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
A0A4W2DRK4IGv domain-containing protein. (83 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (297 aa)
IL17FInterleukin 17F. (170 aa)
PPP3CCSerine/threonine-protein phosphatase. (531 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
A0A4W2DVU2PAS domain-containing protein. (743 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (726 aa)
IL2RGFibronectin type-III domain-containing protein. (403 aa)
LOC113881774Ig-like domain-containing protein. (304 aa)
STAT1Signal transducer and activator of transcription. (821 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (764 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
NFKBIBNFKB inhibitor beta. (357 aa)
IL2RAInterleukin 2 receptor subunit alpha. (275 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
A0A4W2EDY1Ig-like domain-containing protein. (318 aa)
IL1R1Interleukin 1 receptor type 1. (573 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
ZAP70Tyrosine-protein kinase. (617 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
A0A4W2EPY6Ig-like domain-containing protein. (102 aa)
A0A4W2EQ07Ig-like domain-containing protein. (95 aa)
A0A4W2EQ96Ig-like domain-containing protein. (157 aa)
A0A4W2EQA0Ig-like domain-containing protein. (207 aa)
A0A4W2EQB9Ig-like domain-containing protein. (189 aa)
A0A4W2EQG3Ig-like domain-containing protein. (217 aa)
A0A4W2EQH2Ig-like domain-containing protein. (102 aa)
A0A4W2ERF0Ig-like domain-containing protein. (150 aa)
A0A4W2ERG5Ig-like domain-containing protein. (136 aa)
A0A4W2ERJ1Ig-like domain-containing protein. (174 aa)
A0A4W2ERJ9Ig-like domain-containing protein. (181 aa)
A0A4W2ERN6Ig-like domain-containing protein. (127 aa)
A0A4W2ERP9Ig-like domain-containing protein. (331 aa)
A0A4W2ES23Uncharacterized protein. (128 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (135 aa)
A0A4W2ES53Ig-like domain-containing protein. (222 aa)
A0A4W2ES87IGv domain-containing protein. (140 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
A0A4W2EX93BHLH domain-containing protein. (119 aa)
JAK3Tyrosine-protein kinase. (1181 aa)
IL6Interleukin 6. (208 aa)
IFNGR2Interferon gamma receptor 2. (376 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
CD247CD247 molecule. (166 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (260 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
IL21RInterleukin 21 receptor. (531 aa)
JAK1Tyrosine-protein kinase. (1110 aa)
NFATC3Nuclear factor of activated T cells 3. (1073 aa)
IL1RAPInterleukin 1 receptor accessory protein. (685 aa)
RORCRAR related orphan receptor C. (611 aa)
IL22Interleukin 22. (189 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
FOXP3Forkhead box P3. (454 aa)
LCKTyrosine-protein kinase. (509 aa)
RXRBRetinoid X receptor beta. (536 aa)
LOC113881562Ig-like domain-containing protein; Belongs to the MHC class II family. (253 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
NFKB1Nuclear factor kappa B subunit 1. (974 aa)
A0A4W2I9H2Ig-like domain-containing protein. (102 aa)
A0A4W2I9W6Ig-like domain-containing protein. (167 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
IL17AInterleukin 17A. (153 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
IL17DInterleukin 17D. (197 aa)
IRF4Interferon regulatory factor 4. (451 aa)
IL4RInterleukin 4 receptor. (844 aa)
RXRARetinoid X receptor alpha. (657 aa)
SMAD2Mothers against decapentaplegic homolog. (626 aa)
LATUncharacterized protein. (295 aa)
CD3ECD3e molecule. (197 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
RARARetinoic acid receptor alpha. (477 aa)
CD3DCD3d molecule. (167 aa)
A0A4W2BXT5Ig-like domain-containing protein. (260 aa)
TBX21T-box transcription factor 21. (532 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (269 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (253 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (271 aa)
A0A4W2C1X2Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (774 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
A0A4W2CFU3Ig-like domain-containing protein. (259 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
NFATC2Nuclear factor of activated T cells 2. (914 aa)
CD4CD4 molecule. (455 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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