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A0A4W2D2S0 A0A4W2D2S0 A0A4W2D2R2 A0A4W2D2R2 A0A4W2D2L8 A0A4W2D2L8 DLG1 DLG1 A0A4W2D0I4 A0A4W2D0I4 A0A4W2D0G3 A0A4W2D0G3 A0A4W2D0E0 A0A4W2D0E0 A0A4W2D0D6 A0A4W2D0D6 A0A4W2D095 A0A4W2D095 A0A4W2D056 A0A4W2D056 GSK3B GSK3B A0A4W2CWK6 A0A4W2CWK6 PAK5 PAK5 PIK3CD PIK3CD PTPN6 PTPN6 MAPK1 MAPK1 CD4 CD4 NFATC2 NFATC2 GRB2 GRB2 MAP3K8 MAP3K8 A0A4W2CJ16 A0A4W2CJ16 AKT2 AKT2 A0A4W2CFU1 A0A4W2CFU1 MAP3K7 MAP3K7 MAPK12 MAPK12 LCP2 LCP2 CD8A CD8A PIK3R1 PIK3R1 MAPK11 MAPK11 MALT1 MALT1 CD3D CD3D IKBKB IKBKB PPP3CB PPP3CB CD3E CD3E LAT LAT RAF1 RAF1 A0A4W2D2S8 A0A4W2D2S8 A0A4W2D2T1 A0A4W2D2T1 A0A4W2D2W9 A0A4W2D2W9 A0A4W2D326 A0A4W2D326 CSDE1 CSDE1 MAP2K1 MAP2K1 MAPK8 MAPK8 A0A4W2D520 A0A4W2D520 A0A4W2D547 A0A4W2D547 A0A4W2D552 A0A4W2D552 A0A4W2D597 A0A4W2D597 A0A4W2BM53 A0A4W2BM53 TEC TEC ICOS ICOS CTLA4 CTLA4 NFKBIA NFKBIA SOS1 SOS1 MAPK3 MAPK3 A0A4W2I9W6 A0A4W2I9W6 A0A4W2I9H2 A0A4W2I9H2 NFKB1 NFKB1 JUN JUN PAK1 PAK1 LCK LCK MAP2K7 MAP2K7 A0A4W2D5F7 A0A4W2D5F7 A0A4W2D5G0 A0A4W2D5G0 A0A4W2D5H8 A0A4W2D5H8 A0A4W2D5P0 A0A4W2D5P0 A0A4W2D704 A0A4W2D704 A0A4W2D709 A0A4W2D709 A0A4W2D724 A0A4W2D724 A0A4W2D760 A0A4W2D760 A0A4W2D781 A0A4W2D781 A0A4W2D7C1 A0A4W2D7C1 CDC42 CDC42 PDPK1 PDPK1 A0A4W2DK77 A0A4W2DK77 A0A4W2DK85 A0A4W2DK85 PAK2 PAK2 FOS FOS A0A4W2DMB6 A0A4W2DMB6 TRBV24-1 TRBV24-1 A0A4W2DMM0 A0A4W2DMM0 IL5 IL5 NRAS NRAS CBLB CBLB PIK3CA PIK3CA ERAS ERAS PDCD1 PDCD1 A0A4W2DRK4 A0A4W2DRK4 PPP3CC PPP3CC MAPK13 MAPK13 VAV2 VAV2 KRAS KRAS PIK3CB PIK3CB MAP3K14 MAP3K14 PAK4 PAK4 PRKCQ PRKCQ CD28 CD28 NFKBIB NFKBIB AKT3 AKT3 SOS2 SOS2 RASGRP1 RASGRP1 GRAP2 GRAP2 TNF TNF PTPRC PTPRC IFNG IFNG PAK6 PAK6 FYN FYN CDK4 CDK4 PTK6 PTK6 ZAP70 ZAP70 BCL10 BCL10 PLCG1 PLCG1 A0A4W2EPY6 A0A4W2EPY6 A0A4W2EQ07 A0A4W2EQ07 A0A4W2EQ96 A0A4W2EQ96 A0A4W2EQA0 A0A4W2EQA0 A0A4W2EQB9 A0A4W2EQB9 A0A4W2EQG3 A0A4W2EQG3 A0A4W2EQH2 A0A4W2EQH2 A0A4W2ERF0 A0A4W2ERF0 A0A4W2ERG5 A0A4W2ERG5 VAV3 VAV3 A0A4W2ERJ1 A0A4W2ERJ1 A0A4W2ERJ9 A0A4W2ERJ9 CSF2 CSF2 A0A4W2ERN6 A0A4W2ERN6 A0A4W2ERP9 A0A4W2ERP9 A0A4W2ES23 A0A4W2ES23 IL4 IL4 A0A4W2ES53 A0A4W2ES53 A0A4W2ES87 A0A4W2ES87 PIK3R3 PIK3R3 PPP3CA PPP3CA ITK ITK CD247 CD247 MAPK9 MAPK9 VAV1 VAV1 CHUK CHUK IL2 IL2 RHOA RHOA AKT1 AKT1 PIK3R2 PIK3R2 NCK2 NCK2 MAP2K2 MAP2K2 RELA RELA A0A4W2G5Q0 A0A4W2G5Q0 CARD11 CARD11 MAPK10 MAPK10 SRMS SRMS NFATC3 NFATC3 A0A4W2GYG4 A0A4W2GYG4 NCK1 NCK1 HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A4W2D2S0Ig-like domain-containing protein. (174 aa)
A0A4W2D2R2Ig-like domain-containing protein. (118 aa)
A0A4W2D2L8Ig-like domain-containing protein. (147 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
A0A4W2D0I4Ig-like domain-containing protein. (112 aa)
A0A4W2D0G3Ig-like domain-containing protein. (151 aa)
A0A4W2D0E0Ig-like domain-containing protein. (136 aa)
A0A4W2D0D6Ig-like domain-containing protein. (177 aa)
A0A4W2D095Ig-like domain-containing protein. (143 aa)
A0A4W2D056Ig-like domain-containing protein. (153 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
A0A4W2CWK6Ig-like domain-containing protein. (210 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
CD4CD4 molecule. (455 aa)
NFATC2Nuclear factor of activated T cells 2. (914 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (477 aa)
A0A4W2CJ16Uncharacterized protein. (252 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
A0A4W2CFU1Protein kinase domain-containing protein. (79 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
LCP2Lymphocyte cytosolic protein 2. (532 aa)
CD8ACD8a molecule. (242 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MALT1MALT1 paracaspase. (850 aa)
CD3DCD3d molecule. (167 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
CD3ECD3e molecule. (197 aa)
LATUncharacterized protein. (295 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
A0A4W2D2S8Ig-like domain-containing protein. (127 aa)
A0A4W2D2T1Ig-like domain-containing protein. (127 aa)
A0A4W2D2W9Ig-like domain-containing protein. (261 aa)
A0A4W2D326Uncharacterized protein. (165 aa)
CSDE1Cold shock domain containing E1. (844 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
A0A4W2D520Ig-like domain-containing protein. (202 aa)
A0A4W2D547Ig-like domain-containing protein. (146 aa)
A0A4W2D552Ig-like domain-containing protein. (153 aa)
A0A4W2D597Ig-like domain-containing protein. (112 aa)
A0A4W2BM53Uncharacterized protein. (103 aa)
TECTyrosine-protein kinase. (655 aa)
ICOSInducible T cell costimulator. (209 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (221 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
A0A4W2I9W6Ig-like domain-containing protein. (167 aa)
A0A4W2I9H2Ig-like domain-containing protein. (102 aa)
NFKB1Nuclear factor kappa B subunit 1. (974 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
LCKTyrosine-protein kinase. (509 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (658 aa)
A0A4W2D5F7Ig-like domain-containing protein. (182 aa)
A0A4W2D5G0Ig-like domain-containing protein. (106 aa)
A0A4W2D5H8Ig-like domain-containing protein. (237 aa)
A0A4W2D5P0DUF1968 domain-containing protein. (225 aa)
A0A4W2D704Ig-like domain-containing protein. (150 aa)
A0A4W2D709Ig-like domain-containing protein. (165 aa)
A0A4W2D724Ig-like domain-containing protein. (177 aa)
A0A4W2D760Ig-like domain-containing protein. (128 aa)
A0A4W2D781Ig-like domain-containing protein. (137 aa)
A0A4W2D7C1Ig-like domain-containing protein. (127 aa)
CDC42Cell division cycle 42. (191 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (747 aa)
A0A4W2DK77Ig-like domain-containing protein. (193 aa)
A0A4W2DK85Ig-like domain-containing protein. (111 aa)
PAK2Non-specific serine/threonine protein kinase. (600 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
A0A4W2DMB6Ig-like domain-containing protein. (172 aa)
TRBV24-1T cell receptor beta variable 24-1. (97 aa)
A0A4W2DMM0IGv domain-containing protein. (177 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CBLBCbl proto-oncogene B. (939 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ERASES cell expressed Ras. (185 aa)
PDCD1Programmed cell death 1. (289 aa)
A0A4W2DRK4IGv domain-containing protein. (83 aa)
PPP3CCSerine/threonine-protein phosphatase. (531 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (953 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (764 aa)
CD28CD28 molecule. (265 aa)
NFKBIBNFKB inhibitor beta. (357 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
GRAP2GRB2 related adaptor protein 2. (315 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1243 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
FYNTyrosine-protein kinase. (537 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
PTK6Tyrosine-protein kinase. (450 aa)
ZAP70Tyrosine-protein kinase. (617 aa)
BCL10BCL10 immune signaling adaptor. (230 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
A0A4W2EPY6Ig-like domain-containing protein. (102 aa)
A0A4W2EQ07Ig-like domain-containing protein. (95 aa)
A0A4W2EQ96Ig-like domain-containing protein. (157 aa)
A0A4W2EQA0Ig-like domain-containing protein. (207 aa)
A0A4W2EQB9Ig-like domain-containing protein. (189 aa)
A0A4W2EQG3Ig-like domain-containing protein. (217 aa)
A0A4W2EQH2Ig-like domain-containing protein. (102 aa)
A0A4W2ERF0Ig-like domain-containing protein. (150 aa)
A0A4W2ERG5Ig-like domain-containing protein. (136 aa)
VAV3Vav guanine nucleotide exchange factor 3. (977 aa)
A0A4W2ERJ1Ig-like domain-containing protein. (174 aa)
A0A4W2ERJ9Ig-like domain-containing protein. (181 aa)
CSF2Colony stimulating factor 2. (143 aa)
A0A4W2ERN6Ig-like domain-containing protein. (127 aa)
A0A4W2ERP9Ig-like domain-containing protein. (331 aa)
A0A4W2ES23Uncharacterized protein. (128 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (135 aa)
A0A4W2ES53Ig-like domain-containing protein. (222 aa)
A0A4W2ES87IGv domain-containing protein. (140 aa)
PIK3R3Uncharacterized protein. (461 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ITKTyrosine-protein kinase. (620 aa)
CD247CD247 molecule. (166 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
VAV1Vav guanine nucleotide exchange factor 1. (872 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
RHOARas homolog family member A. (193 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
PIK3R2Uncharacterized protein. (724 aa)
NCK2Cytoplasmic protein. (376 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
A0A4W2G5Q0Protein kinase domain-containing protein. (79 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
SRMSTyrosine-protein kinase. (504 aa)
NFATC3Nuclear factor of activated T cells 3. (1073 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
NCK1Cytoplasmic protein. (377 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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