(78 nodes) Fc epsilon RI signaling pathway network (Bos indicus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SRMS	Tyrosine-protein kinase. (504 aa)
	GAB2	GRB2 associated binding protein 2. (666 aa)
	INPP5D	Inositol polyphosphate-5-phosphatase D. (1194 aa)
	A0A4W2GYG4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (658 aa)
	IL13	Interleukin 13. (146 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
	JMJD7	Jumonji domain containing 7. (316 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
	A0A4W2BTN1	Uncharacterized protein. (508 aa)
	A0A4W2BTN2	Ig-like domain-containing protein. (130 aa)
	LAT	Uncharacterized protein. (295 aa)
	A0A4W2BVW3	Ig-like domain-containing protein. (218 aa)
	A0A4W2BWE6	Ig-like domain-containing protein. (204 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (412 aa)
	RAC3	Rac family small GTPase 3. (258 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	RAC1	Rac family small GTPase 1. (257 aa)
	A0A4W2CAP3	Ig-like domain-containing protein. (182 aa)
	A0A4W2CAP7	Ig-like domain-containing protein. (213 aa)
	A0A4W2CAS0	Ig-like domain-containing protein. (223 aa)
	LCP2	Lymphocyte cytosolic protein 2. (532 aa)
	MAPK12	Mitogen-activated protein kinase. (367 aa)
	AKT2	AKT serine/threonine kinase 2. (603 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	MAPK1	Mitogen-activated protein kinase. (634 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
	PLA2G4E	Phospholipase A2. (860 aa)
	A0A4W2CZ07	Phospholipase A2. (821 aa)
	A0A4W2D326	Uncharacterized protein. (165 aa)
	LOC113896625	Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (144 aa)
	CSDE1	Cold shock domain containing E1. (844 aa)
	MAP2K1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	FCER1A	Fc fragment of IgE receptor Ia. (260 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (747 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
	SYK	Tyrosine-protein kinase. (628 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ERAS	ES cell expressed Ras. (185 aa)
	MAPK13	Mitogen-activated protein kinase. (455 aa)
	A0A4W2DX14	Ig-like domain-containing protein. (160 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (878 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
	PLA2G4A	Phospholipase A2. (749 aa)
	A0A4W2EA01	Uncharacterized protein. (48 aa)
	AKT3	AKT serine/threonine kinase 3. (564 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	PLA2G4D	Phospholipase A2. (808 aa)
	LYN	Tyrosine-protein kinase. (491 aa)
	MS4A2	Membrane spanning 4-domains A2. (243 aa)
	MAP2K3	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	PTK6	Tyrosine-protein kinase. (450 aa)
	PLA2G4F	Phospholipase A2. (845 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
	ALOX5	Arachidonate 5-lipoxygenase. (674 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (977 aa)
	CSF2	Colony stimulating factor 2. (143 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (135 aa)
	PIK3R3	Uncharacterized protein. (461 aa)
	RAC2	Rac family small GTPase 2. (209 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
	ALOX5AP	Arachidonate 5-lipoxygenase activating protein. (162 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (872 aa)
	AKT1	Non-specific serine/threonine protein kinase. (747 aa)
	PIK3R2	Uncharacterized protein. (724 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
	MAPK10	Mitogen-activated protein kinase. (425 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2BTN1	FCER1A	A0A4W2BTN1	A0A4W2DEU9	Uncharacterized protein.	Fc fragment of IgE receptor Ia.	0.782
A0A4W2BTN1	GRB2	A0A4W2BTN1	A0A4W2CKJ4	Uncharacterized protein.	Growth factor receptor bound protein 2.	0.429
A0A4W2BTN1	LYN	A0A4W2BTN1	A0A4W2EEP1	Uncharacterized protein.	Tyrosine-protein kinase.	0.764
A0A4W2BTN1	MS4A2	A0A4W2BTN1	A0A4W2EF79	Uncharacterized protein.	Membrane spanning 4-domains A2.	0.767
A0A4W2BTN1	PLCG1	A0A4W2BTN1	A0A4W2EN52	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.753
A0A4W2BTN1	PLCG2	A0A4W2BTN1	A0A4W2F9Q0	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.753
A0A4W2BTN1	SYK	A0A4W2BTN1	A0A4W2DNE9	Uncharacterized protein.	Tyrosine-protein kinase.	0.840
A0A4W2BTN2	A0A4W2BVW3	A0A4W2BTN2	A0A4W2BVW3	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.567
A0A4W2BTN2	A0A4W2CAP3	A0A4W2BTN2	A0A4W2CAP3	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.567
A0A4W2BTN2	A0A4W2CAP7	A0A4W2BTN2	A0A4W2CAP7	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.651
A0A4W2BTN2	A0A4W2CAS0	A0A4W2BTN2	A0A4W2CAS0	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.651
A0A4W2BTN2	A0A4W2DX14	A0A4W2BTN2	A0A4W2DX14	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.567
A0A4W2BTN2	LYN	A0A4W2BTN2	A0A4W2EEP1	Ig-like domain-containing protein.	Tyrosine-protein kinase.	0.815
A0A4W2BTN2	MS4A2	A0A4W2BTN2	A0A4W2EF79	Ig-like domain-containing protein.	Membrane spanning 4-domains A2.	0.815
A0A4W2BTN2	PLCG1	A0A4W2BTN2	A0A4W2EN52	Ig-like domain-containing protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.805
A0A4W2BTN2	PLCG2	A0A4W2BTN2	A0A4W2F9Q0	Ig-like domain-containing protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.805
A0A4W2BTN2	SYK	A0A4W2BTN2	A0A4W2DNE9	Ig-like domain-containing protein.	Tyrosine-protein kinase.	0.812
A0A4W2BVW3	A0A4W2BTN2	A0A4W2BVW3	A0A4W2BTN2	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.567
A0A4W2BVW3	A0A4W2CAP3	A0A4W2BVW3	A0A4W2CAP3	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.765
A0A4W2BVW3	A0A4W2CAP7	A0A4W2BVW3	A0A4W2CAP7	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.455

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