STRINGSTRING
GSN GSN ARPC1B ARPC1B WASF3 WASF3 RPS6KB1 RPS6KB1 RAF1 RAF1 A0A4W2BTN1 A0A4W2BTN1 A0A4W2BTN2 A0A4W2BTN2 LAT LAT RPS6KB2 RPS6KB2 A0A4W2BVW3 A0A4W2BVW3 A0A4W2BWE6 A0A4W2BWE6 DOCK1 DOCK1 PLA2G6 PLA2G6 ARPC1A ARPC1A ARPC4 ARPC4 LIMK2 LIMK2 PIK3R1 PIK3R1 A0A4W2CAP3 A0A4W2CAP3 A0A4W2CAP7 A0A4W2CAP7 A0A4W2CAS0 A0A4W2CAS0 PLD2 PLD2 PLPP1 PLPP1 CCDC125 CCDC125 ASAP1 ASAP1 PRKCE PRKCE AKT2 AKT2 MAPK1 MAPK1 CRKL CRKL MARCKSL1 MARCKSL1 PIK3CD PIK3CD PLA2G4E PLA2G4E A0A4W2CZ07 A0A4W2CZ07 A0A4W2CZR5 A0A4W2CZR5 SPHK2 SPHK2 A0A4W2D456 A0A4W2D456 MAP2K1 MAP2K1 FCGR1A FCGR1A BOLA1 BOLA1 CDC42 CDC42 A0A4W2DHA5 A0A4W2DHA5 SPHK1 SPHK1 A0A4W2DX14 A0A4W2DX14 VAV2 VAV2 PIK3CB PIK3CB PLA2G4A PLA2G4A CFL2 CFL2 A0A4W2EA01 A0A4W2EA01 INPPL1 INPPL1 AKT3 AKT3 PRKCG PRKCG ARPC5L ARPC5L PLA2G4D PLA2G4D LYN LYN PTPRC PTPRC ARPC2 ARPC2 ARPC3 ARPC3 ARF6 ARF6 AMPH AMPH PLA2G4F PLA2G4F PLCG1 PLCG1 VAV3 VAV3 PLD1 PLD1 PIP5K1A PIP5K1A A0A4W2EV68 A0A4W2EV68 SCIN SCIN ASAP3 ASAP3 PIK3R3 PIK3R3 FCGR2B FCGR2B RAC2 RAC2 A0A4W2F1P2 A0A4W2F1P2 BIN1 BIN1 MYO10 MYO10 PLCG2 PLCG2 WASF1 WASF1 WASF2 WASF2 MARCKS MARCKS VAV1 VAV1 AKT1 AKT1 PIK3R2 PIK3R2 GOLGA2 GOLGA2 PIP5K1B PIP5K1B GAB2 GAB2 PRKCA PRKCA ASAP2 ASAP2 VASP VASP INPP5D INPP5D A0A4W2GYG4 A0A4W2GYG4 HCK HCK ARPC5 ARPC5 CFL1 CFL1 PIP5K1C PIP5K1C PAK1 PAK1 PRKCB PRKCB MAPK3 MAPK3 JMJD7 JMJD7 PLPP3 PLPP3 A0A4W2DLK7 A0A4W2DLK7 SYK SYK WAS WAS DNM2 DNM2 PRKCD PRKCD PIK3CA PIK3CA CRK CRK LIMK1 LIMK1 NCF1 NCF1 DOCK5 DOCK5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSNGelsolin. (846 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
WASF3WASP family member 3. (501 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
A0A4W2BTN1Uncharacterized protein. (508 aa)
A0A4W2BTN2Ig-like domain-containing protein. (130 aa)
LATUncharacterized protein. (295 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
A0A4W2BVW3Ig-like domain-containing protein. (218 aa)
A0A4W2BWE6Ig-like domain-containing protein. (204 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1888 aa)
PLA2G6Phospholipase A2 group VI. (805 aa)
ARPC1AWD_REPEATS_REGION domain-containing protein. (430 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
LIMK2LIM domain kinase 2. (628 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
A0A4W2CAP3Ig-like domain-containing protein. (182 aa)
A0A4W2CAP7Ig-like domain-containing protein. (213 aa)
A0A4W2CAS0Ig-like domain-containing protein. (223 aa)
PLD2Phospholipase. (1088 aa)
PLPP1Phospholipid phosphatase 1. (286 aa)
CCDC125Coiled-coil domain containing 125. (513 aa)
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. (1126 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
CRKLCRK like proto-oncogene, adaptor protein. (302 aa)
MARCKSL1MARCKS like 1. (288 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
PLA2G4EPhospholipase A2. (860 aa)
A0A4W2CZ07Phospholipase A2. (821 aa)
A0A4W2CZR5Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (406 aa)
SPHK2Sphingosine kinase 2. (661 aa)
A0A4W2D456acidPPc domain-containing protein. (368 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
FCGR1AUncharacterized protein. (349 aa)
BOLA1BolA family member 1; Belongs to the BolA/IbaG family. (138 aa)
CDC42Cell division cycle 42. (191 aa)
A0A4W2DHA5Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (159 aa)
SPHK1Sphingosine kinase 1. (489 aa)
A0A4W2DX14Ig-like domain-containing protein. (160 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PLA2G4APhospholipase A2. (749 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
A0A4W2EA01Uncharacterized protein. (48 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1264 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (771 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
PLA2G4DPhospholipase A2. (808 aa)
LYNTyrosine-protein kinase. (491 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1243 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (190 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (148 aa)
AMPHAmphiphysin. (853 aa)
PLA2G4FPhospholipase A2. (845 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
VAV3Vav guanine nucleotide exchange factor 3. (977 aa)
PLD1Phospholipase. (1126 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
A0A4W2EV68acidPPc domain-containing protein. (458 aa)
SCINScinderin. (832 aa)
ASAP3ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (883 aa)
PIK3R3Uncharacterized protein. (461 aa)
FCGR2BUncharacterized protein. (316 aa)
RAC2Rac family small GTPase 2. (209 aa)
A0A4W2F1P2ANAPC4_WD40 domain-containing protein. (204 aa)
BIN1Bridging integrator 1. (602 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2052 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
WASF1WASP family member 1. (570 aa)
WASF2WASP family member 2. (493 aa)
MARCKSMyristoylated alanine rich protein kinase C substrate. (333 aa)
VAV1Vav guanine nucleotide exchange factor 1. (872 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
PIK3R2Uncharacterized protein. (724 aa)
GOLGA2Uncharacterized protein. (1032 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (519 aa)
GAB2GRB2 associated binding protein 2. (666 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2. (1008 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (383 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1194 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
HCKTyrosine-protein kinase. (558 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (166 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (695 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
JMJD7Jumonji domain containing 7. (316 aa)
PLPP3acidPPc domain-containing protein. (311 aa)
A0A4W2DLK7Uncharacterized protein. (250 aa)
SYKTyrosine-protein kinase. (628 aa)
WASWASP actin nucleation promoting factor. (559 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CRKCRK proto-oncogene, adaptor protein. (376 aa)
LIMK1LIM domain kinase 1. (778 aa)
NCF1Neutrophil cytosolic factor 1. (392 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1864 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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