(111 nodes) Leukocyte transendothelial migration network (Bos indicus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CLDN10	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (231 aa)
	ARHGAP35	Rho GTPase activating protein 35. (1500 aa)
	VASP	Vasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (383 aa)
	MYL2	Myosin light chain 2. (166 aa)
	CTNNA3	Catenin alpha 3. (895 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	CYBB	Cytochrome b-245 beta chain. (570 aa)
	F11R	F11 receptor. (298 aa)
	MMP9	Matrix metallopeptidase 9. (712 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	PIK3R2	Uncharacterized protein. (724 aa)
	CTNNA1	Catenin alpha 1. (919 aa)
	RHOA	Ras homolog family member A. (193 aa)
	CD99	CD99 molecule (Xg blood group). (186 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (872 aa)
	GNAI2	G protein subunit alpha i2. (436 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
	ITK	Tyrosine-protein kinase. (620 aa)
	ITGB2	Integrin beta. (769 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	JAM2	Junctional adhesion molecule 2. (298 aa)
	RAC2	Rac family small GTPase 2. (209 aa)
	GABPA	GA binding protein transcription factor subunit alpha. (454 aa)
	CLDN8	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
	PIK3R3	Uncharacterized protein. (461 aa)
	CLDN11	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (242 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1008 aa)
	ACTN1	Actinin alpha 1. (962 aa)
	CLDN1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (977 aa)
	CLDN16	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (257 aa)
	CXCL12	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (204 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
	RASSF5	Ras association domain family member 5. (423 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
	CLDN20	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (771 aa)
	PECAM1	Platelet and endothelial cell adhesion molecule 1. (868 aa)
	ACTBL2	Actin beta like 2. (376 aa)
	ACTN4	Actinin alpha 4. (933 aa)
	CDH5	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
	NCF4	Neutrophil cytosolic factor 4. (339 aa)
	ACTB	Actin beta. (375 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (878 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1356 aa)
	MAPK13	Mitogen-activated protein kinase. (455 aa)
	NCF1	Neutrophil cytosolic factor 1. (392 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	A0A4W2DPM7	TPR_REGION domain-containing protein. (325 aa)
	A0A4W2DNG0	Ig-like domain-containing protein. (591 aa)
	A0A4W2DNF6	Ig-like domain-containing protein. (488 aa)
	ITGAL	Integrin subunit alpha L; Belongs to the integrin alpha chain family. (1165 aa)
	GNAI1	G protein subunit alpha i1. (417 aa)
	CLDN3	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (267 aa)
	A0A4W2DK14	Uncharacterized protein. (350 aa)
	CLDN14	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (326 aa)
	TXK	Tyrosine-protein kinase. (527 aa)
	CDC42	Cell division cycle 42. (191 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (1011 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1338 aa)
	A0A4W2D4V5	Uncharacterized protein. (607 aa)
	VCAM1	Vascular cell adhesion molecule 1. (740 aa)
	EZR	Ezrin. (638 aa)
	MYL9	Myosin light chain 9. (172 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (923 aa)
	ROCK2	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1469 aa)
	AFDN	Afadin, adherens junction formation factor. (2158 aa)
	OCLN	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
	MYL7	Myosin light chain 7. (226 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
	CTNND1	Catenin delta 1. (966 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1139 aa)
	LPXN	Leupaxin. (399 aa)
	MAPK12	Mitogen-activated protein kinase. (367 aa)
	CTNNA2	Catenin alpha 2. (953 aa)
	MMP2	Matrix metallopeptidase 2. (661 aa)
	MYL12B	Myosin light chain 12B. (171 aa)
	MYL12A	Myosin light chain 12A. (178 aa)
	NCF2	Neutrophil cytosolic factor 2. (575 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	PXN	Uncharacterized protein. (1066 aa)
	CYBA	Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (191 aa)
	A0A4W2C1S8	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	MMP20	Matrix metallopeptidase 20. (483 aa)
	LOC113885006	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
	VCL	Vinculin. (1134 aa)
	CLDN25	Claudin 25. (230 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (919 aa)
	THY1	Thy-1 cell surface antigen. (161 aa)
	SIPA1	Signal-induced proliferation-associated 1. (1102 aa)
	CTNNB1	Catenin beta 1. (774 aa)
	ESAM	Endothelial cell adhesion molecule. (396 aa)
	MYLPF	Myosin light chain, phosphorylatable, fast skeletal muscle. (170 aa)
	JAM3	Junctional adhesion molecule 3. (353 aa)
	CLDN6	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
	CLDN9	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
	CLDN17	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
	CLDN7	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	CLDN23	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (293 aa)
	CLDN4	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
	CLDN19	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
	RAP1B	Uncharacterized protein. (184 aa)
	ARHGAP5	Rho GTPase activating protein 5. (1503 aa)
	ACTL8	Actin like 8; Belongs to the actin family. (365 aa)
	CLDN18	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2C1S8	CLDN1	A0A4W2C1S8	A0A4W2ES13	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.802
A0A4W2C1S8	CLDN11	A0A4W2C1S8	A0A4W2EUL5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.805
A0A4W2C1S8	CLDN16	A0A4W2C1S8	A0A4W2ERB5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.841
A0A4W2C1S8	CLDN17	A0A4W2C1S8	A0A4W2IK22	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.814
A0A4W2C1S8	CLDN20	A0A4W2C1S8	A0A4W2EE45	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.806
A0A4W2C1S8	CLDN23	A0A4W2C1S8	A0A4W2HK42	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.841
A0A4W2C1S8	CLDN25	A0A4W2C1S8	A0A4W2BVT3	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin 25.	0.806
A0A4W2C1S8	CLDN6	A0A4W2C1S8	A0A4W2BKP8	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.804
A0A4W2C1S8	CLDN8	A0A4W2C1S8	A0A4W2EZF3	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.810
A0A4W2C1S8	CLDN9	A0A4W2C1S8	A0A4W2BKP7	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.802
A0A4W2C1S8	LOC113885006	A0A4W2C1S8	A0A4W2BYK3	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.742
A0A4W2C1S8	OCLN	A0A4W2C1S8	A0A4W2CUV3	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family.	0.808
A0A4W2D4V5	ITGB1	A0A4W2D4V5	A0A4W2GGZ1	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.451
A0A4W2D4V5	ITGB2	A0A4W2D4V5	A0A4W2F269	Uncharacterized protein.	Integrin beta.	0.405
A0A4W2D4V5	ITK	A0A4W2D4V5	A0A4W2F2U3	Uncharacterized protein.	Tyrosine-protein kinase.	0.446
A0A4W2D4V5	LPXN	A0A4W2D4V5	A0A4W2CIR0	Uncharacterized protein.	Leupaxin.	0.464
A0A4W2D4V5	PECAM1	A0A4W2D4V5	A0A4W2E8Z4	Uncharacterized protein.	Platelet and endothelial cell adhesion molecule 1.	0.848
A0A4W2D4V5	PIK3CA	A0A4W2D4V5	A0A4W2DQB3	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.889
A0A4W2D4V5	PIK3CB	A0A4W2D4V5	A0A4W2DY00	Uncharacterized protein.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.851
A0A4W2D4V5	PIK3CD	A0A4W2D4V5	A0A4W2CS93	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.851

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