STRINGSTRING
GRIN2A GRIN2A MTNR1B MTNR1B GNG13 GNG13 ITPR1 ITPR1 ADCY9 ADCY9 GNB2 GNB2 GNG3 GNG3 PLCB3 PLCB3 ITPR3 ITPR3 GNG4 GNG4 GRIA4 GRIA4 RASD1 RASD1 CACNA1C CACNA1C A0A4W2C3X9 A0A4W2C3X9 A0A4W2C435 A0A4W2C435 PER1 PER1 NOS1 NOS1 GNAO1 GNAO1 GRIA2 GRIA2 PLCB1 PLCB1 GUCY1A1 GUCY1A1 RYR1 RYR1 RYR2 RYR2 A0A4W2CJ06 A0A4W2CJ06 MAPK1 MAPK1 ADCYAP1R1 ADCYAP1R1 GNG2 GNG2 GNB5 GNB5 PLCB2 PLCB2 RYR3 RYR3 GNAS GNAS ADCY2 ADCY2 PTRHD1 PTRHD1 ADCY6 ADCY6 RPS6KA5 RPS6KA5 CALM1 CALM1 GNG10 GNG10 PRKG2 PRKG2 ADCY4 ADCY4 A0A4W2D7G9 A0A4W2D7G9 GNGT1 GNGT1 A0A4W2DC91 A0A4W2DC91 C3H1orf226 C3H1orf226 ADCY10 ADCY10 A0A4W2DHH5 A0A4W2DHH5 FOS FOS A0A4W2DLH5 A0A4W2DLH5 GNAI1 GNAI1 CACNA1D CACNA1D CACNA1H CACNA1H CAMK2G CAMK2G A0A4W2DSL7 A0A4W2DSL7 PER2 PER2 MTNR1A MTNR1A CACNA1G CACNA1G A0A4W2DUV7 A0A4W2DUV7 CACNA1I CACNA1I PRKG1 PRKG1 ADCY7 ADCY7 GRIN2C GRIN2C ADCY8 ADCY8 GNB3 GNB3 GNG8 GNG8 CREB1 CREB1 GNB1 GNB1 PLCB4 PLCB4 ADCY1 ADCY1 PRKCG PRKCG GRIN2D GRIN2D A0A4W2EIV4 A0A4W2EIV4 ADCY3 ADCY3 ADCY5 ADCY5 GNAI3 GNAI3 CALML4 CALML4 GNB4 GNB4 KCNJ3 KCNJ3 KCNJ9 KCNJ9 CAMK2D CAMK2D A0A4W2F2N7 A0A4W2F2N7 GRIN2B GRIN2B GNAI2 GNAI2 GNAQ GNAQ GNG11 GNG11 GUCY1B1 GUCY1B1 GNG7 GNG7 PRKACA PRKACA ARSI ARSI PRKCA PRKCA CAMK2A CAMK2A FBXO21 FBXO21 GRIN1 GRIN1 PRKACB PRKACB GNG5 GNG5 KCNJ5 KCNJ5 KCNJ6 KCNJ6 ADCYAP1 ADCYAP1 CAMK2B CAMK2B GUCY1A2 GUCY1A2 PRKCB PRKCB GRIA1 GRIA1 MAPK3 MAPK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (365 aa)
GNG13G protein subunit gamma 13. (67 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1117 aa)
GNB2G protein subunit beta 2. (340 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
RASD1Ras related dexamethasone induced 1. (330 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2194 aa)
A0A4W2C3X9ANF_receptor domain-containing protein. (179 aa)
A0A4W2C435AAA_16 domain-containing protein. (1196 aa)
PER1Period circadian regulator 1. (1285 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
GNAO1G protein subunit alpha o1. (377 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (691 aa)
RYR1Ryanodine receptor 1. (5040 aa)
RYR2Ryanodine receptor 2. (4967 aa)
A0A4W2CJ06Guanylate cyclase domain-containing protein. (325 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (524 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (123 aa)
GNB5G protein subunit beta 5. (452 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1226 aa)
RYR3Ryanodine receptor 3. (4872 aa)
GNASGNAS complex locus. (1004 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (945 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (365 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKG2cGMP-dependent protein kinase. (747 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
A0A4W2D7G9Uncharacterized protein. (242 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (134 aa)
A0A4W2DC91Uncharacterized protein. (241 aa)
C3H1orf226PID domain-containing protein. (683 aa)
ADCY10Adenylate cyclase 10. (1614 aa)
A0A4W2DHH5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
A0A4W2DLH5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (103 aa)
GNAI1G protein subunit alpha i1. (417 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2259 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (596 aa)
A0A4W2DSL7Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (627 aa)
PER2Period circadian regulator 2. (1311 aa)
MTNR1AMelatonin receptor 1A; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2380 aa)
A0A4W2DUV7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (87 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2208 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (872 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1253 aa)
GNB3G protein subunit beta 3. (356 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
GNB1G protein subunit beta 1. (358 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1218 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1197 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (771 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1333 aa)
A0A4W2EIV4EF-hand domain-containing protein; Belongs to the calmodulin family. (87 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CALML4Calmodulin like 4. (153 aa)
GNB4G protein subunit beta 4. (340 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (434 aa)
CAMK2DProtein kinase domain-containing protein. (544 aa)
A0A4W2F2N7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (198 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1497 aa)
GNAI2G protein subunit alpha i2. (436 aa)
GNAQG protein subunit alpha q. (359 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
ARSIArylsulfatase family member I. (574 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
FBXO21F-box protein 21. (627 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (367 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (830 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (730 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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