STRINGSTRING
MAPK11 MAPK11 YWHAE YWHAE IRAK2 IRAK2 A0A4W2BS34 A0A4W2BS34 RAF1 RAF1 BCL2 BCL2 IKBKB IKBKB A0A4W2BZH9 A0A4W2BZH9 ATF4 ATF4 SH2B2 SH2B2 BEX3 BEX3 PIK3R1 PIK3R1 BAD BAD MAP3K1 MAP3K1 FOXO3 FOXO3 RIPK2 RIPK2 MAPK12 MAPK12 AKT2 AKT2 NTF4 NTF4 GRB2 GRB2 MAPK7 MAPK7 NTF3 NTF3 SHC4 SHC4 MAPK1 MAPK1 CRKL CRKL A0A4W2CR26 A0A4W2CR26 PIK3CD PIK3CD ABL1 ABL1 IRAK3 IRAK3 MAP3K5 MAP3K5 GSK3B GSK3B BDNF BDNF ZFR2 ZFR2 RPS6KA5 RPS6KA5 CALM1 CALM1 CSDE1 CSDE1 MAP2K1 MAP2K1 MAPK8 MAPK8 A0A4W2D4V5 A0A4W2D4V5 RAPGEF1 RAPGEF1 MAP2K5 MAP2K5 CDC42 CDC42 PDPK1 PDPK1 PRDM4 PRDM4 ARHGDIG ARHGDIG SHC3 SHC3 SH2B1 SH2B1 NRAS NRAS PRKCD PRKCD PIK3CA PIK3CA ERAS ERAS CRK CRK CAMK2G CAMK2G MAPK13 MAPK13 KRAS KRAS PIK3CB PIK3CB SH2B3 SH2B3 MAP3K3 MAP3K3 A0A4W2E7C9 A0A4W2E7C9 ZNF274 ZNF274 NFKBIB NFKBIB FASLG FASLG AKT3 AKT3 SOS2 SOS2 ARHGDIA ARHGDIA A0A4W2EIV4 A0A4W2EIV4 FRS2 FRS2 PLCG1 PLCG1 RPS6KA2 RPS6KA2 BRAF BRAF PSEN1 PSEN1 CALML4 CALML4 NGF NGF A0A4W2EUW0 A0A4W2EUW0 PIK3R3 PIK3R3 CAMK2D CAMK2D MAPK9 MAPK9 CAMK4 CAMK4 PLCG2 PLCG2 RPS6KA1 RPS6KA1 SHC1 SHC1 RHOA RHOA AKT1 AKT1 SORT1 SORT1 PIK3R2 PIK3R2 MAP2K2 MAP2K2 MATK MATK RELA RELA RAP1A RAP1A TP73 TP73 A0A4W2G4L9 A0A4W2G4L9 MAPK10 MAPK10 NTRK2 NTRK2 ARSI ARSI CAMK2A CAMK2A NTRK3 NTRK3 PTPN11 PTPN11 A0A4W2GYG4 A0A4W2GYG4 BAX BAX ZFR ZFR HRAS HRAS RAP1B RAP1B GAB1 GAB1 MAP2K7 MAP2K7 MAPKAPK2 MAPKAPK2 NTRK1 NTRK1 A0A4W2HNE3 A0A4W2HNE3 CAMK2B CAMK2B TP53 TP53 JUN JUN NFKB1 NFKB1 KIDINS220 KIDINS220 MAPK3 MAPK3 IRAK4 IRAK4 SOS1 SOS1 NFKBIA NFKBIA PSEN2 PSEN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK11Mitogen-activated protein kinase. (364 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (268 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (621 aa)
A0A4W2BS34Uncharacterized protein. (147 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
A0A4W2BZH9Uncharacterized protein. (727 aa)
ATF4Activating transcription factor 4. (348 aa)
SH2B2SH2B adaptor protein 2. (669 aa)
BEX3Brain expressed X-linked 3. (107 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BADBCL2 associated agonist of cell death. (168 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1507 aa)
FOXO3Forkhead box O3. (617 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (306 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (781 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (297 aa)
SHC4SHC adaptor protein 4. (630 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
CRKLCRK like proto-oncogene, adaptor protein. (302 aa)
A0A4W2CR26TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (615 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1366 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (258 aa)
ZFR2Zinc finger RNA binding protein 2. (1018 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (945 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (365 aa)
CSDE1Cold shock domain containing E1. (844 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
A0A4W2D4V5Uncharacterized protein. (607 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1265 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (463 aa)
CDC42Cell division cycle 42. (191 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (747 aa)
PRDM4PR/SET domain 4. (808 aa)
ARHGDIGRho GDP dissociation inhibitor gamma. (225 aa)
SHC3SHC adaptor protein 3. (587 aa)
SH2B1SH2B adaptor protein 1. (860 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ERASES cell expressed Ras. (185 aa)
CRKCRK proto-oncogene, adaptor protein. (376 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (596 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
SH2B3SH2B adaptor protein 3. (587 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
A0A4W2E7C9TNF receptor-associated factor. (411 aa)
ZNF274Zinc finger protein 274. (626 aa)
NFKBIBNFKB inhibitor beta. (357 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (277 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
ARHGDIARho GDP dissociation inhibitor alpha. (204 aa)
A0A4W2EIV4EF-hand domain-containing protein; Belongs to the calmodulin family. (87 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
RPS6KA2Ribosomal protein S6 kinase. (759 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (478 aa)
CALML4Calmodulin like 4. (153 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (294 aa)
A0A4W2EUW0Uncharacterized protein. (559 aa)
PIK3R3Uncharacterized protein. (461 aa)
CAMK2DProtein kinase domain-containing protein. (544 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CAMK4Protein kinase domain-containing protein. (750 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
RPS6KA1Ribosomal protein S6 kinase. (844 aa)
SHC1SHC adaptor protein 1. (584 aa)
RHOARas homolog family member A. (193 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
SORT1Sortilin. (909 aa)
PIK3R2Uncharacterized protein. (724 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
MATKTyrosine-protein kinase. (495 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (640 aa)
A0A4W2G4L9Uncharacterized protein. (148 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
NTRK2Tyrosine-protein kinase receptor. (837 aa)
ARSIArylsulfatase family member I. (574 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
ZFRDZF domain-containing protein. (1073 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RAP1BUncharacterized protein. (184 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (658 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (409 aa)
NTRK1Tyrosine-protein kinase receptor. (821 aa)
A0A4W2HNE3DZF domain-containing protein. (103 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (830 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
NFKB1Nuclear factor kappa B subunit 1. (974 aa)
KIDINS220Kinase D interacting substrate 220. (1781 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (461 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (449 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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