STRINGSTRING
CHRM2 CHRM2 CACNA1B CACNA1B MAPK3 MAPK3 PRKCB PRKCB JAK2 JAK2 CHRM3 CHRM3 CAMK2B CAMK2B KCNJ6 KCNJ6 HRAS HRAS KCNQ4 KCNQ4 GNG5 GNG5 PRKACB PRKACB A0A4W2GYG4 A0A4W2GYG4 KCNQ1 KCNQ1 CAMK2A CAMK2A PRKCA PRKCA ARSI ARSI PRKACA PRKACA SRMS SRMS GNA11 GNA11 GNG7 GNG7 CREB5 CREB5 PIK3R2 PIK3R2 GNG11 GNG11 AKT1 AKT1 GNAQ GNAQ GNAI2 GNAI2 CAMK4 CAMK4 A0A4W2F2N7 A0A4W2F2N7 CAMK2D CAMK2D KCNJ3 KCNJ3 PIK3R3 PIK3R3 GNB4 GNB4 GNAI3 GNAI3 ADCY5 ADCY5 CHRM5 CHRM5 ADCY3 ADCY3 CREB3L2 CREB3L2 PTK6 PTK6 FYN FYN PRKCG PRKCG AKT3 AKT3 ADCY1 ADCY1 CREB3 CREB3 PLCB4 PLCB4 GNB1 GNB1 CREB1 CREB1 GNG8 GNG8 PIK3R6 PIK3R6 GNB3 GNB3 ADCY8 ADCY8 SLC5A7 SLC5A7 ADCY7 ADCY7 PIK3CB PIK3CB KRAS KRAS CACNA1S CACNA1S CREB3L4 CREB3L4 A0A4W2DUV7 A0A4W2DUV7 CAMK2G CAMK2G ERAS ERAS PIK3CA PIK3CA CACNA1D CACNA1D NRAS NRAS PIK3CG PIK3CG GNAI1 GNAI1 A0A4W2DLH5 A0A4W2DLH5 FOS FOS CREB3L3 CREB3L3 CHRNB2 CHRNB2 A0A4W2DHH5 A0A4W2DHH5 CACNA1A CACNA1A ITPR2 ITPR2 GNGT1 GNGT1 ADCY4 ADCY4 GNG10 GNG10 CHRM4 CHRM4 CHAT CHAT MAP2K1 MAP2K1 CSDE1 CSDE1 KCNJ2 KCNJ2 ADCY6 ADCY6 SLC18A3 SLC18A3 PTRHD1 PTRHD1 ADCY2 ADCY2 PLCB2 PLCB2 GNB5 GNB5 GNG2 GNG2 PIK3CD PIK3CD CHRNA4 CHRNA4 KCNQ2 KCNQ2 MAPK1 MAPK1 CREB3L1 CREB3L1 CHRNB4 CHRNB4 KCNJ14 KCNJ14 AKT2 AKT2 KCNQ3 KCNQ3 PLCB1 PLCB1 KCNQ5 KCNQ5 GNAO1 GNAO1 PIK3R1 PIK3R1 PIK3R5 PIK3R5 LOC113879687 LOC113879687 CACNA1C CACNA1C KCNJ4 KCNJ4 ATF4 ATF4 GNG4 GNG4 ITPR3 ITPR3 BCL2 BCL2 CHRNA6 CHRNA6 PLCB3 PLCB3 GNG3 GNG3 ACHE ACHE GNB2 GNB2 ADCY9 ADCY9 ITPR1 ITPR1 CACNA1F CACNA1F GNG13 GNG13
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (465 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2332 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (602 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (830 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (710 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (367 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (670 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ARSIArylsulfatase family member I. (574 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
SRMSTyrosine-protein kinase. (504 aa)
GNA11G protein subunit alpha 11. (359 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CREB5cAMP responsive element binding protein 5. (538 aa)
PIK3R2Uncharacterized protein. (724 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
GNAQG protein subunit alpha q. (359 aa)
GNAI2G protein subunit alpha i2. (436 aa)
CAMK4Protein kinase domain-containing protein. (750 aa)
A0A4W2F2N7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (198 aa)
CAMK2DProtein kinase domain-containing protein. (544 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
PIK3R3Uncharacterized protein. (461 aa)
GNB4G protein subunit beta 4. (340 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (568 aa)
PTK6Tyrosine-protein kinase. (450 aa)
FYNTyrosine-protein kinase. (537 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (771 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1197 aa)
CREB3cAMP responsive element binding protein 3. (365 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1218 aa)
GNB1G protein subunit beta 1. (358 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (756 aa)
GNB3G protein subunit beta 3. (356 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1253 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (393 aa)
A0A4W2DUV7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (87 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (596 aa)
ERASES cell expressed Ras. (185 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1171 aa)
GNAI1G protein subunit alpha i1. (417 aa)
A0A4W2DLH5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (103 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (456 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (503 aa)
A0A4W2DHH5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2502 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (134 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (541 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (668 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
CSDE1Cold shock domain containing E1. (844 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
SLC18A3Solute carrier family 18 member A3. (524 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1226 aa)
GNB5G protein subunit beta 5. (452 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (123 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (612 aa)
KCNQ2Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. (899 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (560 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (510 aa)
KCNJ14Potassium voltage-gated channel subfamily J member 14. (434 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
KCNQ3Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family. (865 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
KCNQ5Potassium voltage-gated channel subfamily Q member 5; Belongs to the potassium channel family. (934 aa)
GNAO1G protein subunit alpha o1. (377 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (893 aa)
LOC113879687Uncharacterized protein. (514 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2194 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (444 aa)
ATF4Activating transcription factor 4. (348 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (615 aa)
GNB2G protein subunit beta 2. (340 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1117 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1929 aa)
GNG13G protein subunit gamma 13. (67 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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