STRINGSTRING
PLCB3 PLCB3 HTR6 HTR6 ALOX12 ALOX12 JMJD7 JMJD7 CACNA1B CACNA1B MAPK3 MAPK3 PRKCB PRKCB HTR3B HTR3B KCNJ6 KCNJ6 HTR1A HTR1A HRAS HRAS KCNJ5 KCNJ5 GNG5 GNG5 PRKACB PRKACB A0A4W2GYG4 A0A4W2GYG4 PTGS2 PTGS2 HTR3A HTR3A HTR2A HTR2A PRKCA PRKCA PRKACA PRKACA DUSP1 DUSP1 GNG7 GNG7 GNG11 GNG11 GNAQ GNAQ GNAI2 GNAI2 GABRB2 GABRB2 A0A4W2F2Q5 A0A4W2F2Q5 A0A4W2F2N7 A0A4W2F2N7 KCNJ9 KCNJ9 TRPC1 TRPC1 KCNJ3 KCNJ3 GNB4 GNB4 LOC113899002 LOC113899002 A0A4W2ESI2 A0A4W2ESI2 GNAI3 GNAI3 ALOX5 ALOX5 BRAF BRAF ADCY5 ADCY5 PLA2G4F PLA2G4F PLA2G4D PLA2G4D PRKCG PRKCG HTR1B HTR1B PLCB4 PLCB4 GNB1 GNB1 A0A4W2E7K5 A0A4W2E7K5 GNG8 GNG8 PLA2G4A PLA2G4A GNB3 GNB3 HTR1F HTR1F GABRB3 GABRB3 PELP1 PELP1 HTR4 HTR4 APP APP ITPR3 ITPR3 KRAS KRAS CACNA1S CACNA1S CYP4X1 CYP4X1 A0A4W2DWB8 A0A4W2DWB8 A0A4W2DVL4 A0A4W2DVL4 A0A4W2DUV7 A0A4W2DUV7 A0A4W2DUJ9 A0A4W2DUJ9 DDC DDC ERAS ERAS CACNA1D CACNA1D NRAS NRAS GNAI1 GNAI1 A0A4W2DLH5 A0A4W2DLH5 SLC6A4 SLC6A4 A0A4W2DHH5 A0A4W2DHH5 CACNA1A CACNA1A LOC113889809 LOC113889809 ITPR2 ITPR2 A0A4W2DC91 A0A4W2DC91 TPH2 TPH2 HTR5A HTR5A GABRB1 GABRB1 GNGT1 GNGT1 A0A4W2D670 A0A4W2D670 GNG10 GNG10 MAP2K1 MAP2K1 CSDE1 CSDE1 HTR3D HTR3D RAPGEF3 RAPGEF3 A0A4W2CZ07 A0A4W2CZ07 PLA2G4E PLA2G4E PTGS1 PTGS1 GNAS GNAS PLCB2 PLCB2 HTR2B HTR2B GNB5 GNB5 GNG2 GNG2 KCND2 KCND2 MAPK1 MAPK1 LOC113884309 LOC113884309 PLCB1 PLCB1 ALOX15 ALOX15 CYP2W1 CYP2W1 ALOX15B ALOX15B GNAO1 GNAO1 ALOX12B ALOX12B KCNN2 KCNN2 HTR7 HTR7 CACNA1C CACNA1C SLC18A1 SLC18A1 CASP3 CASP3 LOC113884563 LOC113884563 LOC113892154 LOC113892154 GNG4 GNG4 SLC18A2 SLC18A2 GNG13 GNG13 CACNA1F CACNA1F ITPR1 ITPR1 GNB2 GNB2 A0A4W2BQC5 A0A4W2BQC5 GNG3 GNG3 RAF1 RAF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
HTR65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (440 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (676 aa)
JMJD7Jumonji domain containing 7. (316 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2332 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
HTR3B5-hydroxytryptamine receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (436 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
HTR1A5-hydroxytryptamine receptor 1A. (422 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (367 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
HTR3A5-hydroxytryptamine receptor 3A; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (490 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNAQG protein subunit alpha q. (359 aa)
GNAI2G protein subunit alpha i2. (436 aa)
GABRB2Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
A0A4W2F2Q5G_PROTEIN_RECEP_F1_2 domain-containing protein. (373 aa)
A0A4W2F2N7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (198 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (434 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
GNB4G protein subunit beta 4. (340 aa)
LOC113899002Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (463 aa)
A0A4W2ESI2Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (466 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
PLA2G4FPhospholipase A2. (845 aa)
PLA2G4DPhospholipase A2. (808 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (771 aa)
HTR1B5-hydroxytryptamine receptor 1B. (403 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1218 aa)
GNB1G protein subunit beta 1. (358 aa)
A0A4W2E7K5Uncharacterized protein. (657 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
PLA2G4APhospholipase A2. (749 aa)
GNB3G protein subunit beta 3. (356 aa)
HTR1F5-hydroxytryptamine receptor 1F. (366 aa)
GABRB3Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (498 aa)
PELP1Proline, glutamate and leucine rich protein 1. (1217 aa)
HTR45-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (402 aa)
APPAmyloid beta precursor protein. (770 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
CYP4X1Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (515 aa)
A0A4W2DWB8Uncharacterized protein; Belongs to the cytochrome P450 family. (525 aa)
A0A4W2DVL4Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
A0A4W2DUV7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (87 aa)
A0A4W2DUJ9G_PROTEIN_RECEP_F1_2 domain-containing protein. (377 aa)
DDCDopa decarboxylase. (467 aa)
ERASES cell expressed Ras. (185 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNAI1G protein subunit alpha i1. (417 aa)
A0A4W2DLH5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (103 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
A0A4W2DHH5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2502 aa)
LOC113889809Uncharacterized protein. (829 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
A0A4W2DC91Uncharacterized protein. (241 aa)
TPH2Tryptophan hydroxylase 2. (491 aa)
HTR5A5-hydroxytryptamine receptor 5A. (358 aa)
GABRB1Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (474 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (134 aa)
A0A4W2D670BPTI/Kunitz inhibitor domain-containing protein. (115 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
CSDE1Cold shock domain containing E1. (844 aa)
HTR3D5-hydroxytryptamine receptor 3D; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (451 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
A0A4W2CZ07Phospholipase A2. (821 aa)
PLA2G4EPhospholipase A2. (860 aa)
PTGS1Prostaglandin-endoperoxide synthase 1. (635 aa)
GNASGNAS complex locus. (1004 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1226 aa)
HTR2B5-hydroxytryptamine receptor 2B. (538 aa)
GNB5G protein subunit beta 5. (452 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (123 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
LOC113884309PHB domain-containing protein; Belongs to the cytochrome P450 family. (598 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ALOX15Arachidonate 15-lipoxygenase. (663 aa)
CYP2W1Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (491 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (677 aa)
GNAO1G protein subunit alpha o1. (377 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R type. (699 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (854 aa)
HTR75-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (476 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2194 aa)
SLC18A1Solute carrier family 18 member A1. (515 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
LOC113884563Uncharacterized protein; Belongs to the cytochrome P450 family. (492 aa)
LOC113892154Uncharacterized protein. (533 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
SLC18A2Solute carrier family 18 member A2. (682 aa)
GNG13G protein subunit gamma 13. (67 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1929 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
GNB2G protein subunit beta 2. (340 aa)
A0A4W2BQC5Amine oxidase. (225 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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