STRINGSTRING
CACNA1B CACNA1B PPP1R1B PPP1R1B PPP2R2B PPP2R2B GRIN2A GRIN2A GNG13 GNG13 ITPR1 ITPR1 A0A4W2BNE6 A0A4W2BNE6 GNB2 GNB2 A0A4W2BQC5 A0A4W2BQC5 GNG3 GNG3 PLCB3 PLCB3 A0A4W2BU60 A0A4W2BU60 PPP3CB PPP3CB GNAL GNAL DRD2 DRD2 ITPR3 ITPR3 SLC18A2 SLC18A2 GNG4 GNG4 GRIA4 GRIA4 MAPK11 MAPK11 ATF4 ATF4 PPP2R5D PPP2R5D SLC18A1 SLC18A1 CACNA1C CACNA1C A0A4W2C3X9 A0A4W2C3X9 GNAO1 GNAO1 GRIA2 GRIA2 PPP2R1B PPP2R1B PLCB1 PLCB1 MAPK12 MAPK12 A0A4W2CET6 A0A4W2CET6 A0A4W2CG68 A0A4W2CG68 A0A4W2CH33 A0A4W2CH33 AKT2 AKT2 CALY CALY A0A4W2CJQ5 A0A4W2CJQ5 CREB3L1 CREB3L1 GNG2 GNG2 GNB5 GNB5 PLCB2 PLCB2 GNAS GNAS GSK3B GSK3B PPP2R1A PPP2R1A CALM1 CALM1 MAPK8 MAPK8 GNG10 GNG10 COMT COMT PPP2R2A PPP2R2A ATF2 ATF2 GNGT1 GNGT1 PPP2R2C PPP2R2C CLOCK CLOCK A0A4W2DC91 A0A4W2DC91 ITPR2 ITPR2 DRD3 DRD3 CACNA1A CACNA1A A0A4W2DHH5 A0A4W2DHH5 PPP2R3A PPP2R3A CREB3L3 CREB3L3 FOS FOS A0A4W2DLH5 A0A4W2DLH5 GNAI1 GNAI1 CACNA1D CACNA1D CAMK2G CAMK2G PPP1CA PPP1CA DDC DDC DRD4 DRD4 PPP3CC PPP3CC MAPK13 MAPK13 A0A4W2DUV7 A0A4W2DUV7 CREB3L4 CREB3L4 PPP1CC PPP1CC ATF6B ATF6B GNB3 GNB3 GSK3A GSK3A PPP2R5C PPP2R5C TH TH KIF5B KIF5B GNG8 GNG8 CREB1 CREB1 PPP2R3C PPP2R3C ARRB2 ARRB2 GNB1 GNB1 PLCB4 PLCB4 ARNTL ARNTL CREB3 CREB3 AKT3 AKT3 PRKCG PRKCG A0A4W2EIV4 A0A4W2EIV4 ARRB1 ARRB1 CREB3L2 CREB3L2 PPP1CB PPP1CB ADCY5 ADCY5 GNAI3 GNAI3 CALML4 CALML4 DRD5 DRD5 GNB4 GNB4 SCN1A SCN1A KCNJ3 KCNJ3 KIF5C KIF5C KCNJ9 KCNJ9 PPP3CA PPP3CA CAMK2D CAMK2D A0A4W2F2N7 A0A4W2F2N7 MAPK9 MAPK9 PPP2R5E PPP2R5E GRIN2B GRIN2B GNAI2 GNAI2 GNAQ GNAQ AKT1 AKT1 KIF5A KIF5A GNG11 GNG11 CREB5 CREB5 PPP2R5B PPP2R5B GNG7 GNG7 MAPK10 MAPK10 DRD1 DRD1 PRKACA PRKACA ARSI ARSI PRKCA PRKCA CAMK2A CAMK2A PPP2R5A PPP2R5A SLC6A3 SLC6A3 PRKACB PRKACB ARR3 ARR3 GNG5 GNG5 KCNJ5 KCNJ5 PPP2CB PPP2CB PPP2CA PPP2CA PPP2R3B PPP2R3B KCNJ6 KCNJ6 CAMK2B CAMK2B PRKCB PRKCB GRIA1 GRIA1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2332 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (202 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (552 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
GNG13G protein subunit gamma 13. (67 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
A0A4W2BNE6BH4_AAA_HYDROXYL_2 domain-containing protein. (571 aa)
GNB2G protein subunit beta 2. (340 aa)
A0A4W2BQC5Amine oxidase. (225 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
A0A4W2BU60Uncharacterized protein. (82 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
GNALG protein subunit alpha L. (452 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
SLC18A2Solute carrier family 18 member A2. (682 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
ATF4Activating transcription factor 4. (348 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (600 aa)
SLC18A1Solute carrier family 18 member A1. (515 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2194 aa)
A0A4W2C3X9ANF_receptor domain-containing protein. (179 aa)
GNAO1G protein subunit alpha o1. (377 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (805 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
A0A4W2CET6Serine/threonine-protein phosphatase. (259 aa)
A0A4W2CG68Uncharacterized protein. (192 aa)
A0A4W2CH33Metallophos domain-containing protein. (127 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
CALYCalcyon neuron specific vesicular protein. (229 aa)
A0A4W2CJQ5Uncharacterized protein. (258 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (560 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (123 aa)
GNB5G protein subunit beta 5. (452 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1226 aa)
GNASGNAS complex locus. (1004 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (365 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
COMTCatechol-O-methyltransferase. (280 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (484 aa)
ATF2Activating transcription factor 2. (447 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (134 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (428 aa)
CLOCKClock circadian regulator. (844 aa)
A0A4W2DC91Uncharacterized protein. (241 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (479 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2502 aa)
A0A4W2DHH5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (456 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
A0A4W2DLH5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (103 aa)
GNAI1G protein subunit alpha i1. (417 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (596 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
DDCDopa decarboxylase. (467 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (372 aa)
PPP3CCSerine/threonine-protein phosphatase. (531 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
A0A4W2DUV7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (87 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (393 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
ATF6BActivating transcription factor 6 beta. (718 aa)
GNB3G protein subunit beta 3. (356 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (578 aa)
THBH4_AAA_HYDROXYL_2 domain-containing protein. (536 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (990 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
ARRB2Arrestin beta 2. (409 aa)
GNB1G protein subunit beta 1. (358 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1218 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (583 aa)
CREB3cAMP responsive element binding protein 3. (365 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (771 aa)
A0A4W2EIV4EF-hand domain-containing protein; Belongs to the calmodulin family. (87 aa)
ARRB1Arrestin beta 1. (513 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (568 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (445 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CALML4Calmodulin like 4. (153 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (473 aa)
GNB4G protein subunit beta 4. (340 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2009 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (914 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (434 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CAMK2DProtein kinase domain-containing protein. (544 aa)
A0A4W2F2N7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (198 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (468 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1497 aa)
GNAI2G protein subunit alpha i2. (436 aa)
GNAQG protein subunit alpha q. (359 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
KIF5AKinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1032 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
CREB5cAMP responsive element binding protein 5. (538 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (496 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
ARSIArylsulfatase family member I. (574 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (489 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (367 aa)
ARR3Arrestin 3. (389 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PPP2R3BEF-hand domain-containing protein. (611 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (830 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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