STRINGSTRING
MAPK9 MAPK9 ALOX12 ALOX12 JMJD7 JMJD7 PRKCB PRKCB IGF1 IGF1 CAMK2B CAMK2B NTRK1 NTRK1 PRKACB PRKACB IL1RAP IL1RAP HTR2A HTR2A CAMK2A CAMK2A PRKCA PRKCA ARSI ARSI PRKACA PRKACA MAPK10 MAPK10 PIK3R2 PIK3R2 SRC SRC GNAQ GNAQ PLCG2 PLCG2 ITPR1 ITPR1 ADCY9 ADCY9 PLCB3 PLCB3 ASIC2 ASIC2 HRH1 HRH1 ITPR3 ITPR3 MAPK11 MAPK11 LOC113884563 LOC113884563 PLA2G6 PLA2G6 PIK3R1 PIK3R1 CYP2W1 CYP2W1 TRPV1 TRPV1 PTGER4 PTGER4 PLCB1 PLCB1 MAPK12 MAPK12 PRKCE PRKCE P2RY2 P2RY2 LOC113884309 LOC113884309 TRPA1 TRPA1 TRPV4 TRPV4 BDKRB1 BDKRB1 ASIC4 ASIC4 PIK3CD PIK3CD TRPV3 TRPV3 HTR2B HTR2B PLCB2 PLCB2 GNAS GNAS ADCY2 ADCY2 PLA2G4E PLA2G4E A0A4W2CZ07 A0A4W2CZ07 PTRHD1 PTRHD1 ADCY6 ADCY6 ASIC1 ASIC1 CALM1 CALM1 MAPK8 MAPK8 PTGER2 PTGER2 PRKCH PRKCH ADCY4 ADCY4 ASIC3 ASIC3 A0A4W2DB09 A0A4W2DB09 A0A4W2DB19 A0A4W2DB19 CYP4B1 CYP4B1 A0A4W2DC91 A0A4W2DC91 ITPR2 ITPR2 TRPM8 TRPM8 LOC113889809 LOC113889809 A0A4W2DFZ3 A0A4W2DFZ3 LOC113889930 LOC113889930 PRKCD PRKCD PIK3CA PIK3CA CAMK2G CAMK2G PPP1CA PPP1CA MAPK13 MAPK13 A0A4W2DWB8 A0A4W2DWB8 PIK3CB PIK3CB ADCY7 ADCY7 PPP1CC PPP1CC TRPV2 TRPV2 ASIC5 ASIC5 ADCY8 ADCY8 PRKCQ PRKCQ MAP2K6 MAP2K6 PLA2G4A PLA2G4A A0A4W2E7K5 A0A4W2E7K5 PLCB4 PLCB4 ADCY1 ADCY1 PRKCG PRKCG PLA2G4D PLA2G4D IL1R1 IL1R1 MAP2K3 MAP2K3 A0A4W2EIV4 A0A4W2EIV4 IL1B IL1B PLA2G4F PLA2G4F ADCY3 ADCY3 PLCG1 PLCG1 PPP1CB PPP1CB ADCY5 ADCY5 CALML4 CALML4 KNG1 KNG1 NGF NGF PIK3R3 PIK3R3 A0A4W2EXY8 A0A4W2EXY8 CAMK2D CAMK2D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK9Mitogen-activated protein kinase. (424 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (676 aa)
JMJD7Jumonji domain containing 7. (316 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
IGF1Insulin like growth factor 1. (188 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (830 aa)
NTRK1Tyrosine-protein kinase receptor. (821 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (367 aa)
IL1RAPInterleukin 1 receptor accessory protein. (685 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ARSIArylsulfatase family member I. (574 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
PIK3R2Uncharacterized protein. (724 aa)
SRCTyrosine-protein kinase. (559 aa)
GNAQG protein subunit alpha q. (359 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1117 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
ASIC2Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (565 aa)
HRH1Histamine receptor H1; Belongs to the G-protein coupled receptor 1 family. (491 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
LOC113884563Uncharacterized protein; Belongs to the cytochrome P450 family. (492 aa)
PLA2G6Phospholipase A2 group VI. (805 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CYP2W1Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (491 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (837 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (492 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
P2RY2Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (381 aa)
LOC113884309PHB domain-containing protein; Belongs to the cytochrome P450 family. (598 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1119 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (803 aa)
BDKRB1Bradykinin receptor B1. (483 aa)
ASIC4Acid sensing ion channel subunit family member 4; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (654 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (798 aa)
HTR2B5-hydroxytryptamine receptor 2B. (538 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1226 aa)
GNASGNAS complex locus. (1004 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
PLA2G4EPhospholipase A2. (860 aa)
A0A4W2CZ07Phospholipase A2. (821 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
ASIC1Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (559 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (365 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (352 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ASIC3Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (532 aa)
A0A4W2DB09Abhydrolase_3 domain-containing protein. (199 aa)
A0A4W2DB19Abhydrolase_3 domain-containing protein. (204 aa)
CYP4B1Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
A0A4W2DC91Uncharacterized protein. (241 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
TRPM8Transient receptor potential cation channel subfamily M member 8. (1104 aa)
LOC113889809Uncharacterized protein. (829 aa)
A0A4W2DFZ3Uncharacterized protein. (306 aa)
LOC113889930Uncharacterized protein. (906 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (596 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
A0A4W2DWB8Uncharacterized protein; Belongs to the cytochrome P450 family. (525 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (799 aa)
ASIC5Acid sensing ion channel subunit family member 5; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (505 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1253 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (764 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
PLA2G4APhospholipase A2. (749 aa)
A0A4W2E7K5Uncharacterized protein. (657 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1218 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1197 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (771 aa)
PLA2G4DPhospholipase A2. (808 aa)
IL1R1Interleukin 1 receptor type 1. (573 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
A0A4W2EIV4EF-hand domain-containing protein; Belongs to the calmodulin family. (87 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
PLA2G4FPhospholipase A2. (845 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (445 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
CALML4Calmodulin like 4. (153 aa)
KNG1Kininogen 1. (621 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (294 aa)
PIK3R3Uncharacterized protein. (461 aa)
A0A4W2EXY8Uncharacterized protein. (414 aa)
CAMK2DProtein kinase domain-containing protein. (544 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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