STRINGSTRING
TSC2 TSC2 A0A4W2BND6 A0A4W2BND6 PHKG2 PHKG2 FOXO1 FOXO1 A0A4W2BS34 A0A4W2BS34 RPS6KB1 RPS6KB1 RAF1 RAF1 PPP1R3G PPP1R3G RPS6KB2 RPS6KB2 IKBKB IKBKB SOCS1 SOCS1 ELK1 ELK1 HK1 HK1 SREBF2 SREBF2 SH2B2 SH2B2 INPP5A INPP5A KIAA1671 KIAA1671 A0A4W2C5I5 A0A4W2C5I5 PRKAR1B PRKAR1B PPP1R3C PPP1R3C SLC2A4 SLC2A4 CRYBB3 CRYBB3 PIK3R1 PIK3R1 ACACA ACACA BAD BAD PYGM PYGM GEM GEM EFCAB3 EFCAB3 TMEM145 TMEM145 AKT2 AKT2 A0A4W2CIR7 A0A4W2CIR7 PPP1R3A PPP1R3A GRB2 GRB2 SORBS1 SORBS1 A0A4W2CNA5 A0A4W2CNA5 HK2 HK2 SHC4 SHC4 ACACB ACACB MAPK1 MAPK1 CRKL CRKL PIK3CD PIK3CD PRKAB1 PRKAB1 MTOR MTOR RRAD RRAD EFCAB13 EFCAB13 IRS2 IRS2 G6PC G6PC GSK3B GSK3B PRKAR1A PRKAR1A PRKAG1 PRKAG1 RHEBL1 RHEBL1 SOCS2 SOCS2 CALM1 CALM1 TRIP10 TRIP10 CSDE1 CSDE1 MAP2K1 MAP2K1 MAPK8 MAPK8 FBP1 FBP1 MYO9A MYO9A A0A4W2D7S8 A0A4W2D7S8 PRKAA1 PRKAA1 TBCA TBCA A0A4W2HDU0 A0A4W2HDU0 EXOC7 EXOC7 HRAS HRAS PRKACB PRKACB PHKG1 PHKG1 GYS1 GYS1 A0A4W2GYG4 A0A4W2GYG4 G6PC3 G6PC3 PPP1R3E PPP1R3E PPP1R3D PPP1R3D PTPN1 PTPN1 PRKACA PRKACA GCK GCK MAPK10 MAPK10 ELK3 ELK3 A0A4W2G4L9 A0A4W2G4L9 MKNK2 MKNK2 PRKCZ PRKCZ MAP2K2 MAP2K2 PIK3R2 PIK3R2 PTPRS PTPRS MKNK1 MKNK1 AKT1 AKT1 SOCS4 SOCS4 PPP1R3B PPP1R3B PKLR PKLR SHC1 SHC1 BUD23 BUD23 MAPK9 MAPK9 PRKAR2B PRKAR2B PPARGC1A PPARGC1A GYS2 GYS2 RAPGEF1 RAPGEF1 CRYGN CRYGN PYGL PYGL MYO9B MYO9B PRKAA2 PRKAA2 EIF4E EIF4E PTPRF PTPRF PDPK1 PDPK1 A0A4W2DK00 A0A4W2DK00 ALKBH4 ALKBH4 PPP1R3F PPP1R3F SHC3 SHC3 NRAS NRAS CBLB CBLB PIK3CA PIK3CA EIF4E1B EIF4E1B ERAS ERAS CRK CRK PPP1CA PPP1CA TSC1 TSC1 SORBS2 SORBS2 KRAS KRAS PIK3CB PIK3CB PRKAR2A PRKAR2A RPTOR RPTOR PHKB PHKB PPP1CC PPP1CC RHOQ RHOQ FLOT2 FLOT2 PYGB PYGB CBL CBL LIPE LIPE EIF4EBP1 EIF4EBP1 INPPL1 INPPL1 AKT3 AKT3 PCK1 PCK1 SOS2 SOS2 SREBF1 SREBF1 PDE3B PDE3B PRKAG3 PRKAG3 A0A4W2EHI1 A0A4W2EHI1 FASN FASN REM1 REM1 PTPRD PTPRD A0A4W2EIV4 A0A4W2EIV4 RPS6 RPS6 PPP1CB PPP1CB BRAF BRAF PCK2 PCK2 CALML4 CALML4 RHEB RHEB A0A4W2ETA9 A0A4W2ETA9 HK3 HK3 A0A4W2EUW0 A0A4W2EUW0 SORBS3 SORBS3 A0A4W2EVV5 A0A4W2EVV5 G6PC2 G6PC2 PIK3R3 PIK3R3 INSR INSR SOS1 SOS1 MAPK3 MAPK3 FBP2 FBP2 PRKAG2 PRKAG2 EIF4E2 EIF4E2 FLOT1 FLOT1 A0A4W2HP99 A0A4W2HP99 PRKCI PRKCI BMT2 BMT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TSC2TSC complex subunit 2. (1887 aa)
A0A4W2BND6IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa)
FOXO1Forkhead box O1. (604 aa)
A0A4W2BS34Uncharacterized protein. (147 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (344 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
SOCS1Suppressor of cytokine signaling 1. (224 aa)
ELK1ETS transcription factor ELK1. (432 aa)
HK1Hexokinase 1. (920 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1140 aa)
SH2B2SH2B adaptor protein 2. (669 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (412 aa)
KIAA1671KIAA1671. (1800 aa)
A0A4W2C5I5Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (104 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (318 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (311 aa)
EFCAB3EF-hand calcium binding domain 3. (491 aa)
TMEM145Transmembrane protein 145. (631 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
A0A4W2CIR7Uncharacterized protein. (379 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1149 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
SORBS1Sorbin and SH3 domain containing 1. (1469 aa)
A0A4W2CNA5Uncharacterized protein. (589 aa)
HK2Hexokinase 2. (917 aa)
SHC4SHC adaptor protein 4. (630 aa)
ACACBAcetyl-CoA carboxylase beta. (2455 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
CRKLCRK like proto-oncogene, adaptor protein. (302 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
EFCAB13EF-hand calcium binding domain 13. (762 aa)
IRS2Insulin receptor substrate 2. (1325 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (380 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
RHEBL1RHEB like 1. (195 aa)
SOCS2Suppressor of cytokine signaling 2. (202 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (365 aa)
TRIP10Thyroid hormone receptor interactor 10. (603 aa)
CSDE1Cold shock domain containing E1. (844 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
MYO9AMyosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2611 aa)
A0A4W2D7S8Uncharacterized protein. (191 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (108 aa)
A0A4W2HDU0Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (229 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (707 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (367 aa)
PHKG1Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (387 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (736 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (429 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
GCKPhosphotransferase. (466 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
ELK3ETS transcription factor ELK3. (402 aa)
A0A4W2G4L9Uncharacterized protein. (148 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (464 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
PIK3R2Uncharacterized protein. (724 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1998 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (436 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (339 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
SHC1SHC adaptor protein 1. (584 aa)
BUD23BUD23 rRNA methyltransferase and ribosome maturation factor. (281 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (418 aa)
PPARGC1APPARG coactivator 1 alpha. (796 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (702 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1265 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (182 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (859 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2150 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (2037 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (747 aa)
A0A4W2DK00Uncharacterized protein. (591 aa)
ALKBH4AlkB homolog 4, lysine demethylase. (303 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F. (790 aa)
SHC3SHC adaptor protein 3. (587 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CBLBCbl proto-oncogene B. (939 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (132 aa)
ERASES cell expressed Ras. (185 aa)
CRKCRK proto-oncogene, adaptor protein. (376 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
TSC1TSC complex subunit 1. (1165 aa)
SORBS2Sorbin and SH3 domain containing 2. (1201 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (401 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1117 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
RHOQRas homolog family member Q. (209 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (880 aa)
CBLCbl proto-oncogene. (932 aa)
LIPELipase E, hormone sensitive type. (802 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (178 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1264 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (694 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1146 aa)
PDE3BPhosphodiesterase. (1115 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (535 aa)
A0A4W2EHI1Uncharacterized protein. (170 aa)
FASNFatty acid synthase. (2515 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
PTPRDProtein tyrosine phosphatase receptor type D. (1917 aa)
A0A4W2EIV4EF-hand domain-containing protein; Belongs to the calmodulin family. (87 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (445 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (820 aa)
CALML4Calmodulin like 4. (153 aa)
RHEBUncharacterized protein. (214 aa)
A0A4W2ETA9Uncharacterized protein. (132 aa)
HK3Hexokinase 3. (924 aa)
A0A4W2EUW0Uncharacterized protein. (559 aa)
SORBS3Sorbin and SH3 domain containing 3. (783 aa)
A0A4W2EVV5Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (242 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PIK3R3Uncharacterized protein. (461 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (343 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (565 aa)
EIF4E2Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
A0A4W2HP99Tubulin-specific chaperone A; Belongs to the TBCA family. (83 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (636 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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