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TSC2 | TSC complex subunit 2. (1887 aa) | ||||
A0A4W2BND6 | IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa) | ||||
PHKG2 | Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa) | ||||
FOXO1 | Forkhead box O1. (604 aa) | ||||
A0A4W2BS34 | Uncharacterized protein. (147 aa) | ||||
RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) | ||||
RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) | ||||
PPP1R3G | Protein phosphatase 1 regulatory subunit 3G. (344 aa) | ||||
RPS6KB2 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa) | ||||
IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) | ||||
SOCS1 | Suppressor of cytokine signaling 1. (224 aa) | ||||
ELK1 | ETS transcription factor ELK1. (432 aa) | ||||
HK1 | Hexokinase 1. (920 aa) | ||||
SREBF2 | Sterol regulatory element binding transcription factor 2. (1140 aa) | ||||
SH2B2 | SH2B adaptor protein 2. (669 aa) | ||||
INPP5A | Inositol polyphosphate-5-phosphatase A. (412 aa) | ||||
KIAA1671 | KIAA1671. (1800 aa) | ||||
A0A4W2C5I5 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (104 aa) | ||||
PRKAR1B | Protein kinase cAMP-dependent type I regulatory subunit beta. (381 aa) | ||||
PPP1R3C | Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (318 aa) | ||||
SLC2A4 | Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa) | ||||
CRYBB3 | Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa) | ||||
PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) | ||||
ACACA | Acetyl-CoA carboxylase alpha. (2383 aa) | ||||
BAD | BCL2 associated agonist of cell death. (168 aa) | ||||
PYGM | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa) | ||||
GEM | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (311 aa) | ||||
EFCAB3 | EF-hand calcium binding domain 3. (491 aa) | ||||
TMEM145 | Transmembrane protein 145. (631 aa) | ||||
AKT2 | AKT serine/threonine kinase 2. (603 aa) | ||||
A0A4W2CIR7 | Uncharacterized protein. (379 aa) | ||||
PPP1R3A | Protein phosphatase 1 regulatory subunit 3A. (1149 aa) | ||||
GRB2 | Growth factor receptor bound protein 2. (217 aa) | ||||
SORBS1 | Sorbin and SH3 domain containing 1. (1469 aa) | ||||
A0A4W2CNA5 | Uncharacterized protein. (589 aa) | ||||
HK2 | Hexokinase 2. (917 aa) | ||||
SHC4 | SHC adaptor protein 4. (630 aa) | ||||
ACACB | Acetyl-CoA carboxylase beta. (2455 aa) | ||||
MAPK1 | Mitogen-activated protein kinase. (634 aa) | ||||
CRKL | CRK like proto-oncogene, adaptor protein. (302 aa) | ||||
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa) | ||||
PRKAB1 | Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa) | ||||
MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa) | ||||
RRAD | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa) | ||||
EFCAB13 | EF-hand calcium binding domain 13. (762 aa) | ||||
IRS2 | Insulin receptor substrate 2. (1325 aa) | ||||
G6PC | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa) | ||||
GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa) | ||||
PRKAR1A | Protein kinase cAMP-dependent type I regulatory subunit alpha. (380 aa) | ||||
PRKAG1 | Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa) | ||||
RHEBL1 | RHEB like 1. (195 aa) | ||||
SOCS2 | Suppressor of cytokine signaling 2. (202 aa) | ||||
CALM1 | Uncharacterized protein; Belongs to the calmodulin family. (365 aa) | ||||
TRIP10 | Thyroid hormone receptor interactor 10. (603 aa) | ||||
CSDE1 | Cold shock domain containing E1. (844 aa) | ||||
MAP2K1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa) | ||||
MAPK8 | Mitogen-activated protein kinase. (427 aa) | ||||
FBP1 | Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa) | ||||
MYO9A | Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2611 aa) | ||||
A0A4W2D7S8 | Uncharacterized protein. (191 aa) | ||||
PRKAA1 | Non-specific serine/threonine protein kinase. (574 aa) | ||||
TBCA | Tubulin-specific chaperone A; Belongs to the TBCA family. (108 aa) | ||||
A0A4W2HDU0 | Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (229 aa) | ||||
EXOC7 | Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (707 aa) | ||||
HRAS | HRas proto-oncogene, GTPase. (189 aa) | ||||
PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (367 aa) | ||||
PHKG1 | Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (387 aa) | ||||
GYS1 | Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (736 aa) | ||||
A0A4W2GYG4 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa) | ||||
G6PC3 | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa) | ||||
PPP1R3E | Protein phosphatase 1 regulatory subunit 3E. (279 aa) | ||||
PPP1R3D | Protein phosphatase 1 regulatory subunit. (299 aa) | ||||
PTPN1 | Tyrosine-protein phosphatase non-receptor type. (429 aa) | ||||
PRKACA | Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa) | ||||
GCK | Phosphotransferase. (466 aa) | ||||
MAPK10 | Mitogen-activated protein kinase. (425 aa) | ||||
ELK3 | ETS transcription factor ELK3. (402 aa) | ||||
A0A4W2G4L9 | Uncharacterized protein. (148 aa) | ||||
MKNK2 | MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (464 aa) | ||||
PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa) | ||||
MAP2K2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa) | ||||
PIK3R2 | Uncharacterized protein. (724 aa) | ||||
PTPRS | Protein tyrosine phosphatase receptor type S. (1998 aa) | ||||
MKNK1 | MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (436 aa) | ||||
AKT1 | Non-specific serine/threonine protein kinase. (747 aa) | ||||
SOCS4 | Suppressor of cytokine signaling 4. (440 aa) | ||||
PPP1R3B | Protein phosphatase 1 regulatory subunit. (339 aa) | ||||
PKLR | Pyruvate kinase; Belongs to the pyruvate kinase family. (574 aa) | ||||
SHC1 | SHC adaptor protein 1. (584 aa) | ||||
BUD23 | BUD23 rRNA methyltransferase and ribosome maturation factor. (281 aa) | ||||
MAPK9 | Mitogen-activated protein kinase. (424 aa) | ||||
PRKAR2B | Protein kinase cAMP-dependent type II regulatory subunit beta. (418 aa) | ||||
PPARGC1A | PPARG coactivator 1 alpha. (796 aa) | ||||
GYS2 | Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (702 aa) | ||||
RAPGEF1 | Rap guanine nucleotide exchange factor 1. (1265 aa) | ||||
CRYGN | Crystallin gamma N; Belongs to the beta/gamma-crystallin family. (182 aa) | ||||
PYGL | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (859 aa) | ||||
MYO9B | Myosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2150 aa) | ||||
PRKAA2 | Non-specific serine/threonine protein kinase. (552 aa) | ||||
EIF4E | Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa) | ||||
PTPRF | Protein tyrosine phosphatase receptor type F. (2037 aa) | ||||
PDPK1 | 3-phosphoinositide dependent protein kinase 1. (747 aa) | ||||
A0A4W2DK00 | Uncharacterized protein. (591 aa) | ||||
ALKBH4 | AlkB homolog 4, lysine demethylase. (303 aa) | ||||
PPP1R3F | Protein phosphatase 1 regulatory subunit 3F. (790 aa) | ||||
SHC3 | SHC adaptor protein 3. (587 aa) | ||||
NRAS | NRAS proto-oncogene, GTPase. (189 aa) | ||||
CBLB | Cbl proto-oncogene B. (939 aa) | ||||
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) | ||||
EIF4E1B | Eukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (132 aa) | ||||
ERAS | ES cell expressed Ras. (185 aa) | ||||
CRK | CRK proto-oncogene, adaptor protein. (376 aa) | ||||
PPP1CA | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa) | ||||
TSC1 | TSC complex subunit 1. (1165 aa) | ||||
SORBS2 | Sorbin and SH3 domain containing 2. (1201 aa) | ||||
KRAS | KRAS proto-oncogene, GTPase. (189 aa) | ||||
PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) | ||||
PRKAR2A | Protein kinase cAMP-dependent type II regulatory subunit alpha. (401 aa) | ||||
RPTOR | Regulatory associated protein of MTOR complex 1. (1335 aa) | ||||
PHKB | Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1117 aa) | ||||
PPP1CC | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa) | ||||
RHOQ | Ras homolog family member Q. (209 aa) | ||||
FLOT2 | Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa) | ||||
PYGB | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (880 aa) | ||||
CBL | Cbl proto-oncogene. (932 aa) | ||||
LIPE | Lipase E, hormone sensitive type. (802 aa) | ||||
EIF4EBP1 | Eukaryotic translation initiation factor 4E binding protein 1. (178 aa) | ||||
INPPL1 | Inositol polyphosphate phosphatase like 1. (1264 aa) | ||||
AKT3 | AKT serine/threonine kinase 3. (564 aa) | ||||
PCK1 | Phosphoenolpyruvate carboxykinase 1. (694 aa) | ||||
SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) | ||||
SREBF1 | Sterol regulatory element binding transcription factor 1. (1146 aa) | ||||
PDE3B | Phosphodiesterase. (1115 aa) | ||||
PRKAG3 | Protein kinase AMP-activated non-catalytic subunit gamma 3. (535 aa) | ||||
A0A4W2EHI1 | Uncharacterized protein. (170 aa) | ||||
FASN | Fatty acid synthase. (2515 aa) | ||||
REM1 | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa) | ||||
PTPRD | Protein tyrosine phosphatase receptor type D. (1917 aa) | ||||
A0A4W2EIV4 | EF-hand domain-containing protein; Belongs to the calmodulin family. (87 aa) | ||||
RPS6 | 40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa) | ||||
PPP1CB | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (445 aa) | ||||
BRAF | B-Raf proto-oncogene, serine/threonine kinase. (805 aa) | ||||
PCK2 | Phosphoenolpyruvate carboxykinase 2, mitochondrial. (820 aa) | ||||
CALML4 | Calmodulin like 4. (153 aa) | ||||
RHEB | Uncharacterized protein. (214 aa) | ||||
A0A4W2ETA9 | Uncharacterized protein. (132 aa) | ||||
HK3 | Hexokinase 3. (924 aa) | ||||
A0A4W2EUW0 | Uncharacterized protein. (559 aa) | ||||
SORBS3 | Sorbin and SH3 domain containing 3. (783 aa) | ||||
A0A4W2EVV5 | Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (242 aa) | ||||
G6PC2 | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa) | ||||
PIK3R3 | Uncharacterized protein. (461 aa) | ||||
INSR | Tyrosine-protein kinase receptor. (1382 aa) | ||||
SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa) | ||||
MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa) | ||||
FBP2 | Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (343 aa) | ||||
PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (565 aa) | ||||
EIF4E2 | Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (245 aa) | ||||
FLOT1 | Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa) | ||||
A0A4W2HP99 | Tubulin-specific chaperone A; Belongs to the TBCA family. (83 aa) | ||||
PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (636 aa) | ||||
BMT2 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa) |