(91 nodes) Insulin secretion network (Bos indicus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

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	ADCY6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
	PDX1	Pancreatic and duodenal homeobox 1. (285 aa)
	CACNA1F	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1929 aa)
	A0A4W2BND6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1117 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
	FXYD2	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (179 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
	ATF4	Activating transcription factor 4. (348 aa)
	GLP1R	Glucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2194 aa)
	A0A4W2C5I5	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (104 aa)
	KCNN2	Potassium calcium-activated channel subfamily N member 2. (854 aa)
	KCNJ11	Potassium voltage-gated channel subfamily J member 11. (388 aa)
	ABCC8	ATP binding cassette subfamily C member 8. (1529 aa)
	KCNU1	Potassium calcium-activated channel subfamily U member 1. (1136 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	RYR2	Ryanodine receptor 2. (4967 aa)
	FFAR1	Free fatty acid receptor 1. (300 aa)
	KCNN4	Potassium calcium-activated channel subfamily N member 4. (428 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (560 aa)
	RIMS2	Regulating synaptic membrane exocytosis 2. (1682 aa)
	VAMP2	V-SNARE coiled-coil homology domain-containing protein. (118 aa)
	ADCYAP1R1	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (524 aa)
	ATP1B1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1226 aa)
	SNAP25	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
	GNAS	GNAS complex locus. (1004 aa)
	ADCY2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
	PTRHD1	Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
	ADCY4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	ATF2	Activating transcription factor 2. (447 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (1011 aa)
	TNIK	TRAF2 and NCK interacting kinase. (1389 aa)
	A0A4W2DC91	Uncharacterized protein. (241 aa)
	CCKAR	Cholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (456 aa)
	PCLO	Piccolo presynaptic cytomatrix protein. (5221 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
	KCNMB3	Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (277 aa)
	STX1A	Syntaxin 1A. (373 aa)
	CAMK2G	Calcium/calmodulin dependent protein kinase II gamma. (596 aa)
	GIP	Gastric inhibitory polypeptide. (143 aa)
	KCNMA1	Potassium calcium-activated channel subfamily M alpha 1. (1276 aa)
	RAB3A	RAB3A, member RAS oncogene family. (220 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (393 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
	KCNN3	Potassium calcium-activated channel subfamily N member 3. (736 aa)
	RAB3B	RAB3B, member RAS oncogene family. (219 aa)
	ADCY7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
	ATF6B	Activating transcription factor 6 beta. (718 aa)
	ADCY8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1253 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1218 aa)
	CREB3	cAMP responsive element binding protein 3. (365 aa)
	ADCY1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1197 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (771 aa)
	RAB3C	RAB3C, member RAS oncogene family. (227 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (568 aa)
	ADCY3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
	ADCY5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
	SLC2A2	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (532 aa)
	SLC2A1	Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (530 aa)
	KCNN1	Potassium calcium-activated channel subfamily N member 1. (687 aa)
	CAMK2D	Protein kinase domain-containing protein. (544 aa)
	ATP1B3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
	GNAQ	G protein subunit alpha q. (359 aa)
	CREB5	cAMP responsive element binding protein 5. (538 aa)
	GNA11	G protein subunit alpha 11. (359 aa)
	ATP1A4	Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
	ATP1A3	Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
	ATP1A2	Sodium/potassium-transporting ATPase subunit alpha. (1048 aa)
	GCK	Phosphotransferase. (466 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	ATP1A1	Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
	ARSI	Arylsulfatase family member I. (574 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
	GCG	Glucagon. (180 aa)
	FAP	Fibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
	CCK	Cholecystokinin. (131 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (367 aa)
	TRPM4	Transient receptor potential cation channel subfamily M member 4. (1207 aa)
	KCNMB4	Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
	ADCYAP1	Adenylate cyclase activating polypeptide 1. (176 aa)
	CAMK2B	Calcium/calmodulin dependent protein kinase II beta. (830 aa)
	KCNMB1	Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (206 aa)
	KCNMB2	KcnmB2_inactiv domain-containing protein. (268 aa)
	CHRM3	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (602 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2BND6	CACNA1C	A0A4W2BND6	A0A4W2C2Z8	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.813
A0A4W2BND6	CACNA1D	A0A4W2BND6	A0A4W2DPH3	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.808
A0A4W2BND6	CCK	A0A4W2BND6	A0A4W2GWV7	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Cholecystokinin.	0.518
A0A4W2BND6	CREB1	A0A4W2BND6	A0A4W2E7C2	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	cAMP responsive element binding protein 1.	0.452
A0A4W2BND6	FAP	A0A4W2BND6	A0A4W2GPS3	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	0.534
A0A4W2BND6	GCG	A0A4W2BND6	A0A4W2GLX0	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Glucagon.	0.617
A0A4W2BND6	GCK	A0A4W2BND6	A0A4W2GAS3	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Phosphotransferase.	0.497
A0A4W2BND6	GIP	A0A4W2BND6	A0A4W2DU18	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Gastric inhibitory polypeptide.	0.424
A0A4W2BND6	GLP1R	A0A4W2BND6	A0A4W2C2Y8	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Glucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family.	0.562
A0A4W2BND6	PDX1	A0A4W2BND6	A0A4W2BKS5	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Pancreatic and duodenal homeobox 1.	0.617
A0A4W2BND6	PRKACA	A0A4W2BND6	A0A4W2GDJ9	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.465
A0A4W2BND6	PRKACB	A0A4W2BND6	A0A4W2H3R1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.465
A0A4W2BND6	SLC2A1	A0A4W2BND6	A0A4W2EWJ1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.563
A0A4W2BND6	SLC2A2	A0A4W2BND6	A0A4W2EUV3	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.498
A0A4W2BND6	VAMP2	A0A4W2BND6	A0A4W2CNQ1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	V-SNARE coiled-coil homology domain-containing protein.	0.570
A0A4W2C5I5	CACNA1C	A0A4W2C5I5	A0A4W2C2Z8	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.813
A0A4W2C5I5	CACNA1D	A0A4W2C5I5	A0A4W2DPH3	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.808
A0A4W2C5I5	CCK	A0A4W2C5I5	A0A4W2GWV7	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Cholecystokinin.	0.518
A0A4W2C5I5	CREB1	A0A4W2C5I5	A0A4W2E7C2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	cAMP responsive element binding protein 1.	0.452
A0A4W2C5I5	FAP	A0A4W2C5I5	A0A4W2GPS3	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	0.534

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