STRINGSTRING
SOS2 SOS2 CACNA1F CACNA1F ITPR1 ITPR1 ADCY9 ADCY9 PLCB3 PLCB3 RAF1 RAF1 ITPR3 ITPR3 MMP20 MMP20 ELK1 ELK1 MAPK11 MAPK11 ATF4 ATF4 CACNA1C CACNA1C MAP2K4 MAP2K4 EGFR EGFR PLD2 PLD2 MMP2 MMP2 GEM GEM MAP3K1 MAP3K1 EFCAB3 EFCAB3 A0A4W2CDY2 A0A4W2CDY2 PLCB1 PLCB1 MAPK12 MAPK12 GRB2 GRB2 MAPK7 MAPK7 MAPK1 MAPK1 RRAD RRAD EFCAB13 EFCAB13 PLCB2 PLCB2 GNAS GNAS A0A4W2CXU6 A0A4W2CXU6 ADCY2 ADCY2 PLA2G4E PLA2G4E A0A4W2CZ07 A0A4W2CZ07 PTRHD1 PTRHD1 ADCY6 ADCY6 CGA CGA MMP14 MMP14 CALM1 CALM1 CSDE1 CSDE1 MAP2K1 MAP2K1 MAPK8 MAPK8 ADCY4 ADCY4 A0A4W2D8G7 A0A4W2D8G7 PTX3 PTX3 A0A4W2DC91 A0A4W2DC91 ITPR2 ITPR2 CDC42 CDC42 MAP3K4 MAP3K4 EGR1 EGR1 NRAS NRAS CACNA1D CACNA1D PRKCD PRKCD ERAS ERAS CAMK2G CAMK2G MAPK13 MAPK13 CACNA1S CACNA1S KRAS KRAS ADCY7 ADCY7 ADCY8 ADCY8 MAP2K6 MAP2K6 PLA2G4A PLA2G4A MAP3K3 MAP3K3 PLCB4 PLCB4 ADCY1 ADCY1 PLA2G4D PLA2G4D MAP2K3 MAP2K3 REM1 REM1 A0A4W2EIV4 A0A4W2EIV4 PLA2G4F PLA2G4F ADCY3 ADCY3 ADCY5 ADCY5 CALML4 CALML4 PLD1 PLD1 PTK2B PTK2B A0A4W2EUM8 A0A4W2EUM8 GNRHR GNRHR CAMK2D CAMK2D MAPK9 MAPK9 GNAQ GNAQ SRC SRC MAP2K2 MAP2K2 GNA11 GNA11 A0A4W2G2H0 A0A4W2G2H0 ELK3 ELK3 MAPK10 MAPK10 PRKACA PRKACA ARSI ARSI PRKCA PRKCA CAMK2A CAMK2A A0A4W2GYG4 A0A4W2GYG4 PRKACB PRKACB HRAS HRAS MAP2K7 MAP2K7 HBEGF HBEGF CAMK2B CAMK2B JUN JUN PRKCB PRKCB MAPK3 MAPK3 GNRH1 GNRH1 SOS1 SOS1 JMJD7 JMJD7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1929 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1117 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
MMP20Matrix metallopeptidase 20. (483 aa)
ELK1ETS transcription factor ELK1. (432 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
ATF4Activating transcription factor 4. (348 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2194 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (412 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PLD2Phospholipase. (1088 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (311 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1507 aa)
EFCAB3EF-hand calcium binding domain 3. (491 aa)
A0A4W2CDY2Cys_knot domain-containing protein. (129 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (781 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
EFCAB13EF-hand calcium binding domain 13. (762 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1226 aa)
GNASGNAS complex locus. (1004 aa)
A0A4W2CXU6Cys_knot domain-containing protein. (106 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
PLA2G4EPhospholipase A2. (860 aa)
A0A4W2CZ07Phospholipase A2. (821 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (150 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (365 aa)
CSDE1Cold shock domain containing E1. (844 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
A0A4W2D8G7Uncharacterized protein. (65 aa)
PTX3Pentraxin 3. (382 aa)
A0A4W2DC91Uncharacterized protein. (241 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
CDC42Cell division cycle 42. (191 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1654 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
ERASES cell expressed Ras. (185 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (596 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1253 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
PLA2G4APhospholipase A2. (749 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1218 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1197 aa)
PLA2G4DPhospholipase A2. (808 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
A0A4W2EIV4EF-hand domain-containing protein; Belongs to the calmodulin family. (87 aa)
PLA2G4FPhospholipase A2. (845 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
CALML4Calmodulin like 4. (153 aa)
PLD1Phospholipase. (1126 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1008 aa)
A0A4W2EUM8G_PROTEIN_RECEP_F1_2 domain-containing protein. (287 aa)
GNRHRGonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (328 aa)
CAMK2DProtein kinase domain-containing protein. (544 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
GNAQG protein subunit alpha q. (359 aa)
SRCTyrosine-protein kinase. (559 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
GNA11G protein subunit alpha 11. (359 aa)
A0A4W2G2H0Uncharacterized protein. (115 aa)
ELK3ETS transcription factor ELK3. (402 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
ARSIArylsulfatase family member I. (574 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (367 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (658 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (830 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (92 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
JMJD7Jumonji domain containing 7. (316 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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