STRINGSTRING
MAPK1 MAPK1 AGT AGT EDN1 EDN1 MAPK3 MAPK3 NFKB1 NFKB1 PRKCB PRKCB JUN JUN JAK2 JAK2 CDKN1B CDKN1B TGFB2 TGFB2 HRAS HRAS BAX BAX PRKCA PRKCA CYBB CYBB MAPK10 MAPK10 A0A4W2G5Q0 A0A4W2G5Q0 RELA RELA PRKCZ PRKCZ COL1A2 COL1A2 PIK3R2 PIK3R2 AKT1 AKT1 COL1A1 COL1A1 PLCG2 PLCG2 MAPK9 MAPK9 COL3A1 COL3A1 AGTR1 AGTR1 IL6 IL6 PIK3R3 PIK3R3 CXCL8 CXCL8 SMAD3 SMAD3 TGFB3 TGFB3 PLCG1 PLCG1 CDK4 CDK4 THBD THBD IL1B IL1B COL4A1 COL4A1 TNF TNF NOX3 NOX3 VEGFC VEGFC STAT5A STAT5A AKT3 AKT3 CCND1 CCND1 STAT3 STAT3 TGFBR2 TGFBR2 PLCB4 PLCB4 FN1 FN1 STAT1 STAT1 VEGFA VEGFA PIK3CB PIK3CB KRAS KRAS MAPK13 MAPK13 PLCD1 PLCD1 CCL2 CCL2 NOX4 NOX4 ERAS ERAS SMAD4 SMAD4 SERPINE1 SERPINE1 PIK3CA PIK3CA PRKCD PRKCD NRAS NRAS A0A4W2DNG0 A0A4W2DNG0 A0A4W2DNF6 A0A4W2DNF6 EGR1 EGR1 CDC42 CDC42 DIAPH1 DIAPH1 MAPK8 MAPK8 NOS3 NOS3 CSDE1 CSDE1 VCAM1 VCAM1 F3 F3 PLCB2 PLCB2 SELE SELE COL4A2 COL4A2 COL4A3 COL4A3 PIK3CD PIK3CD PLCD4 PLCD4 MFF MFF COL4A4 COL4A4 TGFBR1 TGFBR1 PLCE1 PLCE1 TGFB1 TGFB1 AKT2 AKT2 AGER AGER PRKCE PRKCE IL1A IL1A A0A4W2CFU1 A0A4W2CFU1 MAPK12 MAPK12 PLCB1 PLCB1 STAT5B STAT5B PLCD3 PLCD3 MMP2 MMP2 PIK3R1 PIK3R1 CASP3 CASP3 MAPK11 MAPK11 PIM1 PIM1 MMP20 MMP20 BCL2 BCL2 A0A4W2BU79 A0A4W2BU79 SMAD2 SMAD2 PLCB3 PLCB3 FOXO1 FOXO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase. (634 aa)
AGTAngiotensinogen; Belongs to the serpin family. (476 aa)
EDN1Endothelin 1. (202 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
NFKB1Nuclear factor kappa B subunit 1. (974 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
A0A4W2G5Q0Protein kinase domain-containing protein. (79 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
COL1A2Collagen type I alpha 2 chain. (1364 aa)
PIK3R2Uncharacterized protein. (724 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
COL1A1Collagen type I alpha 1 chain. (1584 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
IL6Interleukin 6. (208 aa)
PIK3R3Uncharacterized protein. (461 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
THBDThrombomodulin. (637 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
NOX3NADPH oxidase 3. (566 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (428 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1218 aa)
FN1Fibronectin 1. (2601 aa)
STAT1Signal transducer and activator of transcription. (821 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (394 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
PLCD1Phosphoinositide phospholipase C. (781 aa)
CCL2C-C motif chemokine. (99 aa)
NOX4NADPH oxidase 4. (578 aa)
ERASES cell expressed Ras. (185 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (641 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
A0A4W2DNG0Ig-like domain-containing protein. (591 aa)
A0A4W2DNF6Ig-like domain-containing protein. (488 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
CDC42Cell division cycle 42. (191 aa)
DIAPH1Diaphanous related formin 1. (1308 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
CSDE1Cold shock domain containing E1. (844 aa)
VCAM1Vascular cell adhesion molecule 1. (740 aa)
F3Coagulation factor III, tissue factor. (370 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1226 aa)
SELESelectin E. (510 aa)
COL4A2Collagen type IV alpha 2 chain. (1824 aa)
COL4A3Collagen type IV alpha 3 chain. (1649 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
PLCD4Phosphoinositide phospholipase C. (791 aa)
MFFMitochondrial fission factor. (409 aa)
COL4A4Collagen type IV alpha 4 chain. (1689 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
PLCE1Phosphoinositide phospholipase C. (1572 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
AGERAdvanced glycosylation end-product specific receptor. (416 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
A0A4W2CFU1Protein kinase domain-containing protein. (79 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
PLCD3Phosphoinositide phospholipase C. (815 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
MMP20Matrix metallopeptidase 20. (483 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
A0A4W2BU79PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (502 aa)
SMAD2Mothers against decapentaplegic homolog. (626 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
FOXO1Forkhead box O1. (604 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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