STRINGSTRING
ADCY7 ADCY7 PBX1 PBX1 ORAI1 ORAI1 LEF1 LEF1 ATF6B ATF6B FZD10 FZD10 ADCY8 ADCY8 CREB1 CREB1 PLCB4 PLCB4 CREB3 CREB3 ADCY1 ADCY1 CCND1 CCND1 CCNE1 CCNE1 CDKN1A CDKN1A RBBP5 RBBP5 WNT8B WNT8B USP8 USP8 CCNE2 CCNE2 CDK4 CDK4 CREB3L2 CREB3L2 ADCY3 ADCY3 KMT2D KMT2D KCNK3 KCNK3 FZD3 FZD3 WDR5B WDR5B ADCY5 ADCY5 BRAF BRAF SP1 SP1 GNAI3 GNAI3 DVL3 DVL3 LOC113888503 LOC113888503 APC2 APC2 A0A4W2EX93 A0A4W2EX93 AGTR1 AGTR1 A0A4W2F271 A0A4W2F271 CAMK2D CAMK2D LDLR LDLR PDE11A PDE11A WNT5A WNT5A WNT2 WNT2 TCF7 TCF7 GNAI2 GNAI2 GNAQ GNAQ FZD1 FZD1 CDK6 CDK6 MAP2K2 MAP2K2 CREB5 CREB5 MEN1 MEN1 GNA11 GNA11 NR4A1 NR4A1 RAP1A RAP1A TCF7L2 TCF7L2 SCARB1 SCARB1 A0A4W2G5Q0 A0A4W2G5Q0 NR5A1 NR5A1 PDE8A PDE8A PRKACA PRKACA ARSI ARSI CAMK2A CAMK2A WNT16 WNT16 WNT10A WNT10A FZD8 FZD8 CDKN2B CDKN2B FZD2 FZD2 A0A4W2GYG4 A0A4W2GYG4 POMC POMC ARMC5 ARMC5 ARNT ARNT PRKACB PRKACB E2F1 E2F1 E2F2 E2F2 RAP1B RAP1B CDKN1B CDKN1B TCF7L1 TCF7L1 WNT3A WNT3A WNT8A WNT8A CDKN2C CDKN2C KCNA3 KCNA3 CDK2 CDK2 FZD4 FZD4 CAMK2B CAMK2B WNT2B WNT2B RB1 RB1 WNT1 WNT1 WNT9B WNT9B MAPK3 MAPK3 AGT AGT E2F3 E2F3 CACNA1F CACNA1F ITPR1 ITPR1 ADCY9 ADCY9 A0A4W2BPW1 A0A4W2BPW1 CTNNB1 CTNNB1 PLCB3 PLCB3 KMT2A KMT2A ASH2L ASH2L ITPR3 ITPR3 ATF4 ATF4 RASD1 RASD1 CYP21A2 CYP21A2 CACNA1C CACNA1C WNT5B WNT5B A0A4W2C3M7 A0A4W2C3M7 KCNA1 KCNA1 KCNA5 KCNA5 A0A4W2C5B8 A0A4W2C5B8 A0A4W2C612 A0A4W2C612 KCNK2 KCNK2 WNT7A WNT7A APC APC EGFR EGFR DVL2 DVL2 AIPL1 AIPL1 KCNA4 KCNA4 WNT3 WNT3 PLCB1 PLCB1 WNT11 WNT11 A0A4W2CFU1 A0A4W2CFU1 FZD7 FZD7 AXIN2 AXIN2 DVL1 DVL1 CREB3L1 CREB3L1 CRHR2 CRHR2 CRH CRH MAPK1 MAPK1 WNT6 WNT6 CRHR1 CRHR1 CYP11A1 CYP11A1 PLCB2 PLCB2 GNAS GNAS WNT10B WNT10B GSK3B GSK3B ADCY2 ADCY2 PTRHD1 PTRHD1 ADCY6 ADCY6 FZD5 FZD5 KCNA10 KCNA10 MAP2K1 MAP2K1 ADCY4 ADCY4 ATF2 ATF2 FZD6 FZD6 WNT4 WNT4 WNT9A WNT9A FH FH NCEH1 NCEH1 A0A4W2DC91 A0A4W2DC91 ITPR2 ITPR2 CDKN2A CDKN2A MRAP MRAP CREB3L3 CREB3L3 AXIN1 AXIN1 GNAI1 GNAI1 KCNA2 KCNA2 CACNA1D CACNA1D WDR5 WDR5 A0A4W2DQS9 A0A4W2DQS9 PDE8B PDE8B AIP AIP CACNA1H CACNA1H CAMK2G CAMK2G STAR STAR WNT7B WNT7B CACNA1G CACNA1G CACNA1I CACNA1I A0A4W2DVU2 A0A4W2DVU2 CREB3L4 CREB3L4 CACNA1S CACNA1S LOC113884536 LOC113884536
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
PBX1PBX homeobox 1. (430 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (303 aa)
LEF1Lymphoid enhancer binding factor 1. (430 aa)
ATF6BActivating transcription factor 6 beta. (718 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1253 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1218 aa)
CREB3cAMP responsive element binding protein 3. (365 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1197 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (428 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
RBBP5RB binding protein 5, histone lysine methyltransferase complex subunit. (538 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1084 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (568 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
KMT2DLysine methyltransferase 2D. (5579 aa)
KCNK3Potassium channel subfamily K member. (402 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WDR5BWD repeat domain 5B. (330 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
SP1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1209 aa)
GNAI3G protein subunit alpha i3. (354 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
LOC1138885033Beta_HSD domain-containing protein. (403 aa)
APC2APC regulator of WNT signaling pathway 2. (2264 aa)
A0A4W2EX93BHLH domain-containing protein. (119 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
A0A4W2F271START domain-containing protein. (319 aa)
CAMK2DProtein kinase domain-containing protein. (544 aa)
LDLRLow density lipoprotein receptor. (845 aa)
PDE11APhosphodiesterase. (926 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
TCF7Transcription factor 7. (473 aa)
GNAI2G protein subunit alpha i2. (436 aa)
GNAQG protein subunit alpha q. (359 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (645 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
CREB5cAMP responsive element binding protein 5. (538 aa)
MEN1Menin 1. (610 aa)
GNA11G protein subunit alpha 11. (359 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (598 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
TCF7L2Transcription factor 7 like 2. (652 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (586 aa)
A0A4W2G5Q0Protein kinase domain-containing protein. (79 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
PDE8APhosphodiesterase. (832 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
ARSIArylsulfatase family member I. (574 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (661 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
POMCProopiomelanocortin. (265 aa)
ARMC5Armadillo repeat containing 5. (940 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (940 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (367 aa)
E2F1E2F transcription factor 1. (437 aa)
E2F2E2F transcription factor 2. (437 aa)
RAP1BUncharacterized protein. (184 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
TCF7L1Transcription factor 7 like 1. (588 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
KCNA3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (576 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (830 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
RB1RB transcriptional corepressor 1. (928 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
AGTAngiotensinogen; Belongs to the serpin family. (476 aa)
E2F3E2F transcription factor 3. (465 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1929 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1117 aa)
A0A4W2BPW1Uncharacterized protein; Belongs to the cytochrome P450 family. (441 aa)
CTNNB1Catenin beta 1. (774 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3710 aa)
ASH2LASH2 like, histone lysine methyltransferase complex subunit. (635 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
ATF4Activating transcription factor 4. (348 aa)
RASD1Ras related dexamethasone induced 1. (330 aa)
CYP21A2Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (497 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2194 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
A0A4W2C3M7Uncharacterized protein; Belongs to the cytochrome P450 family. (424 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (598 aa)
A0A4W2C5B8Uncharacterized protein; Belongs to the cytochrome P450 family. (538 aa)
A0A4W2C612Uncharacterized protein; Belongs to the cytochrome P450 family. (503 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
APCAPC regulator of WNT signaling pathway. (2912 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
AIPL1Aryl hydrocarbon receptor interacting protein like 1. (328 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (661 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
A0A4W2CFU1Protein kinase domain-containing protein. (79 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
AXIN2Axin 2. (836 aa)
DVL1Dishevelled segment polarity protein 1. (708 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (560 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (436 aa)
CRHCorticotropin releasing hormone. (190 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CRHR1Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (435 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (536 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1226 aa)
GNASGNAS complex locus. (1004 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (433 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
KCNA10Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family. (511 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ATF2Activating transcription factor 2. (447 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (585 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
FHFumarate hydratase. (503 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (440 aa)
A0A4W2DC91Uncharacterized protein. (241 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (160 aa)
MRAPUncharacterized protein. (194 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (456 aa)
AXIN1Axin 1. (909 aa)
GNAI1G protein subunit alpha i1. (417 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
WDR5WD repeat domain 5. (334 aa)
A0A4W2DQS9Uncharacterized protein. (374 aa)
PDE8BPhosphodiesterase. (885 aa)
AIPPeptidylprolyl isomerase. (389 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2259 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (596 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (350 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (472 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2380 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2208 aa)
A0A4W2DVU2PAS domain-containing protein. (743 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (393 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
LOC113884536Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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