(74 nodes) Pertussis network (Bos indicus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL6	Interleukin 6. (208 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	CXCL6	C-X-C motif chemokine. (112 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (461 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
	MYD88	MYD88 innate immune signal transduction adaptor. (384 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (974 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
	CFL1	Cofilin 1; Belongs to the actin-binding proteins ADF family. (166 aa)
	NLRP3	NLR family pyrin domain containing 3. (1031 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	LOC113899224-2	GOLD domain-containing protein. (225 aa)
	LOC113899224	Toll like receptor adaptor molecule 2. (232 aa)
	IRF1	Interferon regulatory factor. (322 aa)
	MAPK10	Mitogen-activated protein kinase. (425 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	RHOA	Ras homolog family member A. (193 aa)
	GNAI2	G protein subunit alpha i2. (436 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	A0A4W2F324	Uncharacterized protein. (1784 aa)
	ITGB2	Integrin beta. (769 aa)
	C1QA	Complement C1q A chain. (278 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (240 aa)
	CALML4	Calmodulin like 4. (153 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	TICAM1	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (759 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
	A0A4W2EIV4	EF-hand domain-containing protein; Belongs to the calmodulin family. (87 aa)
	IRF8	Interferon regulatory factor 8. (426 aa)
	LY96	Lymphocyte antigen 96. (160 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
	LOC113906358	Uncharacterized protein. (613 aa)
	CFL2	Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
	A0A4W2E866	C-type lectin domain-containing protein. (285 aa)
	SERPING1	Serpin family G member 1; Belongs to the serpin family. (468 aa)
	A0A4W2E7C9	TNF receptor-associated factor. (411 aa)
	A0A4W2E4Y6	Uncharacterized protein; Belongs to the peptidase S1 family. (329 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
	C1S	Complement C1s; Belongs to the peptidase S1 family. (695 aa)
	A0A4W2DXX3	C-type lectin domain-containing protein. (279 aa)
	MAPK13	Mitogen-activated protein kinase. (455 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1156 aa)
	GNAI1	G protein subunit alpha i1. (417 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	ITGA5	Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1164 aa)
	C1QB	C1q domain-containing protein. (300 aa)
	C1QC	Complement C1q C chain. (243 aa)
	CD14	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (373 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
	C5	Complement C5. (1677 aa)
	CALM1	Uncharacterized protein; Belongs to the calmodulin family. (365 aa)
	C3	Complement C3. (1695 aa)
	EFCAB13	EF-hand calcium binding domain 13. (762 aa)
	IL23A	Interleukin 23 subunit alpha. (192 aa)
	A0A4W2CR26	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
	MAPK1	Mitogen-activated protein kinase. (634 aa)
	IRF3	Interferon regulatory factor 3. (417 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (954 aa)
	A0A4W2CJ16	Uncharacterized protein. (252 aa)
	LOC113881524	Uncharacterized protein. (1741 aa)
	IL1A	Interleukin-1; Belongs to the IL-1 family. (268 aa)
	C4BPB	Complement component 4 binding protein beta. (209 aa)
	MAPK12	Mitogen-activated protein kinase. (367 aa)
	CCDC125	Coiled-coil domain containing 125. (513 aa)
	EFCAB3	EF-hand calcium binding domain 3. (491 aa)
	C1R	Uncharacterized protein; Belongs to the peptidase S1 family. (774 aa)
	TMED3	Transmembrane p24 trafficking protein 3. (254 aa)
	TIRAP	TIR domain containing adaptor protein. (327 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (277 aa)
	C2	Complement C2; Belongs to the peptidase S1 family. (750 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (320 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2CJ16	A0A4W2CR26	A0A4W2CJ16	A0A4W2CR26	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.435
A0A4W2CJ16	A0A4W2E7C9	A0A4W2CJ16	A0A4W2E7C9	Uncharacterized protein.	TNF receptor-associated factor.	0.435
A0A4W2CJ16	CASP3	A0A4W2CJ16	A0A4W2C1K3	Uncharacterized protein.	Caspase 3; Belongs to the peptidase C14A family.	0.572
A0A4W2CJ16	CXCL6	A0A4W2CJ16	A0A4W2IEF7	Uncharacterized protein.	C-X-C motif chemokine.	0.564
A0A4W2CJ16	CXCL8	A0A4W2CJ16	A0A4W2EW80	Uncharacterized protein.	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.764
A0A4W2CJ16	IL12A	A0A4W2CJ16	A0A4W2EW01	Uncharacterized protein.	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.	0.533
A0A4W2CJ16	IL1A	A0A4W2CJ16	A0A4W2CGC9	Uncharacterized protein.	Interleukin-1; Belongs to the IL-1 family.	0.789
A0A4W2CJ16	IL1B	A0A4W2CJ16	A0A4W2EJN1	Uncharacterized protein.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.934
A0A4W2CJ16	IL6	A0A4W2CJ16	A0A4W2EXX6	Uncharacterized protein.	Interleukin 6.	0.907
A0A4W2CJ16	IRF1	A0A4W2CJ16	A0A4W2GAC6	Uncharacterized protein.	Interferon regulatory factor.	0.493
A0A4W2CJ16	IRF3	A0A4W2CJ16	A0A4W2CMV4	Uncharacterized protein.	Interferon regulatory factor 3.	0.534
A0A4W2CJ16	IRF8	A0A4W2CJ16	A0A4W2EH65	Uncharacterized protein.	Interferon regulatory factor 8.	0.424
A0A4W2CJ16	ITGB1	A0A4W2CJ16	A0A4W2GGZ1	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.424
A0A4W2CJ16	ITGB2	A0A4W2CJ16	A0A4W2F269	Uncharacterized protein.	Integrin beta.	0.406
A0A4W2CJ16	LY96	A0A4W2CJ16	A0A4W2EG14	Uncharacterized protein.	Lymphocyte antigen 96.	0.469
A0A4W2CJ16	MYD88	A0A4W2CJ16	A0A4W2I8U8	Uncharacterized protein.	MYD88 innate immune signal transduction adaptor.	0.692
A0A4W2CJ16	NOD1	A0A4W2CJ16	A0A4W2CM46	Uncharacterized protein.	Nucleotide binding oligomerization domain containing 1.	0.412
A0A4W2CJ16	NOS2	A0A4W2CJ16	A0A4W2DSR0	Uncharacterized protein.	Nitric oxide synthase; Produces nitric oxide (NO).	0.579
A0A4W2CJ16	TLR4	A0A4W2CJ16	A0A4W2D3N2	Uncharacterized protein.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.733
A0A4W2CJ16	TNF	A0A4W2CJ16	A0A4W2EFB5	Uncharacterized protein.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.852

page 1 of 46

Server load: low (14%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2025

Credits

Access

Info

About