STRINGSTRING
PIP5K1B PIP5K1B MAPK10 MAPK10 ITGB1 ITGB1 TAB2 TAB2 NFATC3 NFATC3 LOC113897811 LOC113897811 A0A4W2GYG4 A0A4W2GYG4 ACTL8 ACTL8 NLRP3 NLRP3 PKN2 PKN2 MAP2K7 MAP2K7 LCK LCK PIP5K1C PIP5K1C JUN JUN NFKB1 NFKB1 MYD88 MYD88 A0A4W2I9H2 A0A4W2I9H2 A0A4W2I9W6 A0A4W2I9W6 MAPK3 MAPK3 IRAK4 IRAK4 LOC113896989 LOC113896989 RHOG RHOG NFKBIA NFKBIA PYCARD PYCARD MAPK9 MAPK9 CRK CRK RPS6KA2 RPS6KA2 PLCG1 PLCG1 A0A4W2EML2 A0A4W2EML2 ZAP70 ZAP70 LOC113897812 LOC113897812 IL1B IL1B ARF6 ARF6 WIPF3 WIPF3 TNF TNF MAP2K3 MAP2K3 AKT3 AKT3 A0A4W2EA01 A0A4W2EA01 ARHGEF12 ARHGEF12 FN1 FN1 A0A4W2E7C9 A0A4W2E7C9 ELMO1 ELMO1 ACTBL2 ACTBL2 MAP2K6 MAP2K6 TAB1 TAB1 ARHGEF28 ARHGEF28 ACTR2 ACTR2 BAIAP2 BAIAP2 ACTB ACTB PIK3CB PIK3CB IL18 IL18 VAV2 VAV2 A0A4W2DX14 A0A4W2DX14 ROCK1 ROCK1 MAPK13 MAPK13 CCL2 CCL2 WIPF1 WIPF1 DOCK5 DOCK5 A0A4W2DRK4 A0A4W2DRK4 LIMK1 LIMK1 PIK3CA PIK3CA WAS WAS A0A4W2DMM0 A0A4W2DMM0 TRBV24-1 TRBV24-1 A0A4W2DMB6 A0A4W2DMB6 FOS FOS ITGA5 ITGA5 A0A4W2DK85 A0A4W2DK85 A0A4W2DK77 A0A4W2DK77 A0A4W2DJN4 A0A4W2DJN4 A0A4W2DGC7 A0A4W2DGC7 ACTR3 ACTR3 CDC42 CDC42 WASL WASL A0A4W2DA03 A0A4W2DA03 ARHGEF7 ARHGEF7 A0A4W2D7C1 A0A4W2D7C1 A0A4W2D781 A0A4W2D781 A0A4W2D760 A0A4W2D760 A0A4W2D724 A0A4W2D724 A0A4W2D709 A0A4W2D709 A0A4W2D704 A0A4W2D704 ITGA4 ITGA4 A0A4W2D5P0 A0A4W2D5P0 A0A4W2D5H8 A0A4W2D5H8 A0A4W2D5G0 A0A4W2D5G0 A0A4W2D5F7 A0A4W2D5F7 A0A4W2D597 A0A4W2D597 A0A4W2D552 A0A4W2D552 A0A4W2D547 A0A4W2D547 A0A4W2D520 A0A4W2D520 MAPK8 MAPK8 MAP2K1 MAP2K1 TLR4 TLR4 A0A4W2D2W9 A0A4W2D2W9 A0A4W2D2T1 A0A4W2D2T1 A0A4W2D2S8 A0A4W2D2S8 A0A4W2D2S0 A0A4W2D2S0 A0A4W2D2R2 A0A4W2D2R2 A0A4W2D2L8 A0A4W2D2L8 A0A4W2D0I4 A0A4W2D0I4 A0A4W2D0G3 A0A4W2D0G3 A0A4W2D0E0 A0A4W2D0E0 A0A4W2D0D6 A0A4W2D0D6 A0A4W2D095 A0A4W2D095 A0A4W2D056 A0A4W2D056 ROCK2 ROCK2 GSK3B GSK3B A0A4W2CWK6 A0A4W2CWK6 TBK1 TBK1 FYB1 FYB1 PIK3CD PIK3CD ELMO2 ELMO2 A0A4W2CR26 A0A4W2CR26 CRKL CRKL GIT2 GIT2 MAPK1 MAPK1 CD4 CD4 NFATC2 NFATC2 IRF3 IRF3 PTK2 PTK2 NLRC4 NLRC4 ARHGEF1 ARHGEF1 A0A4W2CJ16 A0A4W2CJ16 LPXN LPXN AKT2 AKT2 MAP3K7 MAP3K7 MAPK12 MAPK12 LCP2 LCP2 CD8A CD8A A0A4W2CAS0 A0A4W2CAS0 A0A4W2CAP7 A0A4W2CAP7 A0A4W2CAP3 A0A4W2CAP3 RAC1 RAC1 PIK3R1 PIK3R1 RAC3 RAC3 PXN PXN A0A4W2BNN2 A0A4W2BNN2 TRAF2 TRAF2 A0A4W2BTN1 A0A4W2BTN1 A0A4W2BTN2 A0A4W2BTN2 LAT LAT BCAR1 BCAR1 A0A4W2BVW3 A0A4W2BVW3 A0A4W2BWE6 A0A4W2BWE6 IKBKB IKBKB WIPF2 WIPF2 MAPK11 MAPK11 DOCK1 DOCK1 MAP2K4 MAP2K4 RPS6KA1 RPS6KA1 WASF2 WASF2 VAV1 VAV1 CHUK CHUK GNAQ GNAQ IL2 IL2 RHOA RHOA SRC SRC PKN1 PKN1 RAC2 RAC2 IL6 IL6 PIK3R3 PIK3R3 CXCL8 CXCL8 PIP5K1A PIP5K1A PTK2B PTK2B A0A4W2ES87 A0A4W2ES87 A0A4W2ES53 A0A4W2ES53 A0A4W2ES23 A0A4W2ES23 A0A4W2ERP9 A0A4W2ERP9 AKT1 AKT1 A0A4W2ERN6 A0A4W2ERN6 A0A4W2ERJ9 A0A4W2ERJ9 A0A4W2ERJ1 A0A4W2ERJ1 VAV3 VAV3 A0A4W2ERG5 A0A4W2ERG5 A0A4W2ERF0 A0A4W2ERF0 A0A4W2EQH2 A0A4W2EQH2 A0A4W2EQG3 A0A4W2EQG3 A0A4W2EQB9 A0A4W2EQB9 TICAM1 TICAM1 A0A4W2EQA0 A0A4W2EQA0 A0A4W2EQ96 A0A4W2EQ96 A0A4W2EQ07 A0A4W2EQ07 A0A4W2EPY6 A0A4W2EPY6 PIK3R2 PIK3R2 MAP2K2 MAP2K2 SKAP2 SKAP2 RELA RELA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (519 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
NFATC3Nuclear factor of activated T cells 3. (1073 aa)
LOC113897811Uncharacterized protein. (186 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
ACTL8Actin like 8; Belongs to the actin family. (365 aa)
NLRP3NLR family pyrin domain containing 3. (1031 aa)
PKN2Protein kinase N2. (981 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (658 aa)
LCKTyrosine-protein kinase. (509 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (695 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
NFKB1Nuclear factor kappa B subunit 1. (974 aa)
MYD88MYD88 innate immune signal transduction adaptor. (384 aa)
A0A4W2I9H2Ig-like domain-containing protein. (102 aa)
A0A4W2I9W6Ig-like domain-containing protein. (167 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (461 aa)
LOC113896989Uncharacterized protein. (186 aa)
RHOGRas homolog family member G. (191 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
PYCARDPYD and CARD domain containing. (195 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CRKCRK proto-oncogene, adaptor protein. (376 aa)
RPS6KA2Ribosomal protein S6 kinase. (759 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
A0A4W2EML2Uncharacterized protein. (186 aa)
ZAP70Tyrosine-protein kinase. (617 aa)
LOC113897812Uncharacterized protein. (186 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (148 aa)
WIPF3WAS/WASL interacting protein family member 3. (486 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
A0A4W2EA01Uncharacterized protein. (48 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
FN1Fibronectin 1. (2601 aa)
A0A4W2E7C9TNF receptor-associated factor. (411 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
ACTBL2Actin beta like 2. (376 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (505 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1737 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (406 aa)
BAIAP2BAI1 associated protein 2. (568 aa)
ACTBActin beta. (375 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
A0A4W2DX14Ig-like domain-containing protein. (160 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1356 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
CCL2C-C motif chemokine. (99 aa)
WIPF1WH2 domain-containing protein. (509 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1864 aa)
A0A4W2DRK4IGv domain-containing protein. (83 aa)
LIMK1LIM domain kinase 1. (778 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
WASWASP actin nucleation promoting factor. (559 aa)
A0A4W2DMM0IGv domain-containing protein. (177 aa)
TRBV24-1T cell receptor beta variable 24-1. (97 aa)
A0A4W2DMB6Ig-like domain-containing protein. (172 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1164 aa)
A0A4W2DK85Ig-like domain-containing protein. (111 aa)
A0A4W2DK77Ig-like domain-containing protein. (193 aa)
A0A4W2DJN4Uncharacterized protein; Belongs to the actin family. (356 aa)
A0A4W2DGC7Uncharacterized protein. (186 aa)
ACTR3Uncharacterized protein; Belongs to the actin family. (418 aa)
CDC42Cell division cycle 42. (191 aa)
WASLWASP like actin nucleation promoting factor. (511 aa)
A0A4W2DA03Uncharacterized protein; Belongs to the actin family. (416 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
A0A4W2D7C1Ig-like domain-containing protein. (127 aa)
A0A4W2D781Ig-like domain-containing protein. (137 aa)
A0A4W2D760Ig-like domain-containing protein. (128 aa)
A0A4W2D724Ig-like domain-containing protein. (177 aa)
A0A4W2D709Ig-like domain-containing protein. (165 aa)
A0A4W2D704Ig-like domain-containing protein. (150 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1338 aa)
A0A4W2D5P0DUF1968 domain-containing protein. (225 aa)
A0A4W2D5H8Ig-like domain-containing protein. (237 aa)
A0A4W2D5G0Ig-like domain-containing protein. (106 aa)
A0A4W2D5F7Ig-like domain-containing protein. (182 aa)
A0A4W2D597Ig-like domain-containing protein. (112 aa)
A0A4W2D552Ig-like domain-containing protein. (153 aa)
A0A4W2D547Ig-like domain-containing protein. (146 aa)
A0A4W2D520Ig-like domain-containing protein. (202 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
A0A4W2D2W9Ig-like domain-containing protein. (261 aa)
A0A4W2D2T1Ig-like domain-containing protein. (127 aa)
A0A4W2D2S8Ig-like domain-containing protein. (127 aa)
A0A4W2D2S0Ig-like domain-containing protein. (174 aa)
A0A4W2D2R2Ig-like domain-containing protein. (118 aa)
A0A4W2D2L8Ig-like domain-containing protein. (147 aa)
A0A4W2D0I4Ig-like domain-containing protein. (112 aa)
A0A4W2D0G3Ig-like domain-containing protein. (151 aa)
A0A4W2D0E0Ig-like domain-containing protein. (136 aa)
A0A4W2D0D6Ig-like domain-containing protein. (177 aa)
A0A4W2D095Ig-like domain-containing protein. (143 aa)
A0A4W2D056Ig-like domain-containing protein. (153 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1469 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
A0A4W2CWK6Ig-like domain-containing protein. (210 aa)
TBK1TANK binding kinase 1. (729 aa)
FYB1FYN binding protein 1. (830 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
ELMO2Engulfment and cell motility 2. (756 aa)
A0A4W2CR26TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
CRKLCRK like proto-oncogene, adaptor protein. (302 aa)
GIT2GIT ArfGAP 2. (759 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
CD4CD4 molecule. (455 aa)
NFATC2Nuclear factor of activated T cells 2. (914 aa)
IRF3Interferon regulatory factor 3. (417 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1139 aa)
NLRC4NLR family CARD domain containing 4. (1017 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (968 aa)
A0A4W2CJ16Uncharacterized protein. (252 aa)
LPXNLeupaxin. (399 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
LCP2Lymphocyte cytosolic protein 2. (532 aa)
CD8ACD8a molecule. (242 aa)
A0A4W2CAS0Ig-like domain-containing protein. (223 aa)
A0A4W2CAP7Ig-like domain-containing protein. (213 aa)
A0A4W2CAP3Ig-like domain-containing protein. (182 aa)
RAC1Rac family small GTPase 1. (257 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RAC3Rac family small GTPase 3. (258 aa)
PXNUncharacterized protein. (1066 aa)
A0A4W2BNN2Uncharacterized protein. (747 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
A0A4W2BTN1Uncharacterized protein. (508 aa)
A0A4W2BTN2Ig-like domain-containing protein. (130 aa)
LATUncharacterized protein. (295 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (919 aa)
A0A4W2BVW3Ig-like domain-containing protein. (218 aa)
A0A4W2BWE6Ig-like domain-containing protein. (204 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
WIPF2WAS/WASL interacting protein family member 2. (511 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1888 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (412 aa)
RPS6KA1Ribosomal protein S6 kinase. (844 aa)
WASF2WASP family member 2. (493 aa)
VAV1Vav guanine nucleotide exchange factor 1. (872 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
GNAQG protein subunit alpha q. (359 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
RHOARas homolog family member A. (193 aa)
SRCTyrosine-protein kinase. (559 aa)
PKN1Protein kinase N1. (956 aa)
RAC2Rac family small GTPase 2. (209 aa)
IL6Interleukin 6. (208 aa)
PIK3R3Uncharacterized protein. (461 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1008 aa)
A0A4W2ES87IGv domain-containing protein. (140 aa)
A0A4W2ES53Ig-like domain-containing protein. (222 aa)
A0A4W2ES23Uncharacterized protein. (128 aa)
A0A4W2ERP9Ig-like domain-containing protein. (331 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
A0A4W2ERN6Ig-like domain-containing protein. (127 aa)
A0A4W2ERJ9Ig-like domain-containing protein. (181 aa)
A0A4W2ERJ1Ig-like domain-containing protein. (174 aa)
VAV3Vav guanine nucleotide exchange factor 3. (977 aa)
A0A4W2ERG5Ig-like domain-containing protein. (136 aa)
A0A4W2ERF0Ig-like domain-containing protein. (150 aa)
A0A4W2EQH2Ig-like domain-containing protein. (102 aa)
A0A4W2EQG3Ig-like domain-containing protein. (217 aa)
A0A4W2EQB9Ig-like domain-containing protein. (189 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (759 aa)
A0A4W2EQA0Ig-like domain-containing protein. (207 aa)
A0A4W2EQ96Ig-like domain-containing protein. (157 aa)
A0A4W2EQ07Ig-like domain-containing protein. (95 aa)
A0A4W2EPY6Ig-like domain-containing protein. (102 aa)
PIK3R2Uncharacterized protein. (724 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
SKAP2Src kinase associated phosphoprotein 2. (358 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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