STRINGSTRING
CASP3 CASP3 LAMC1 LAMC1 CASP8 CASP8 NFKBIA NFKBIA A0A4W2IDQ2 A0A4W2IDQ2 IRAK4 IRAK4 MAPK3 MAPK3 MYD88 MYD88 NFKB1 NFKB1 JAK2 JAK2 HSPA1L HSPA1L LOC113881562 LOC113881562 TGFB2 TGFB2 A0A4W2H7Y7 A0A4W2H7Y7 BCL2L1 BCL2L1 IL10RA IL10RA JAK1 JAK1 TAB2 TAB2 ITGB1 ITGB1 MAPK10 MAPK10 A0A4W2G4L9 A0A4W2G4L9 RELA RELA LOC113891379 LOC113891379 HLA-DOA HLA-DOA AKT1 AKT1 HSPA8 HSPA8 CHUK CHUK GNAI2 GNAI2 MAPK9 MAPK9 PPIF PPIF A0A4W2F3V8 A0A4W2F3V8 LDLR LDLR HSPA6 HSPA6 IFNGR2 IFNGR2 IL10RB IL10RB IL12A IL12A LOC113901903 LOC113901903 GNAI3 GNAI3 TGFB3 TGFB3 ALOX5 ALOX5 IFNG IFNG LY96 LY96 TNF TNF MAP2K3 MAP2K3 A0A4W2EDY1 A0A4W2EDY1 AKT3 AKT3 LAMC3 LAMC3 NFKBIB NFKBIB STAT3 STAT3 CD40 CD40 LAMA3 LAMA3 A0A4W2E8M1 A0A4W2E8M1 A0A4W2E7C9 A0A4W2E7C9 LAMC2 LAMC2 PIK3R6 PIK3R6 MAP2K6 MAP2K6 STAT1 STAT1 IL12B IL12B TAB1 TAB1 LOC113881774 LOC113881774 TNFRSF1A TNFRSF1A MAPK13 MAPK13 LOC113888945 LOC113888945 HLA-DMA HLA-DMA NOS2 NOS2 CCR5 CCR5 LAMB1 LAMB1 PIK3CG PIK3CG GNAI1 GNAI1 PDPK1 PDPK1 TYK2 TYK2 ITGA6 ITGA6 A0A4W2D608 A0A4W2D608 MAPK8 MAPK8 HSPA2 HSPA2 A0A4W2D4T7 A0A4W2D4T7 CASP9 CASP9 TLR4 TLR4 IFNGR1 IFNGR1 BIRC7 BIRC7 C7orf31 C7orf31 A0A4W2CR26 A0A4W2CR26 MAPK1 MAPK1 LAMA2 LAMA2 A0A4W2CJ16 A0A4W2CJ16 TGFB1 TGFB1 AKT2 AKT2 A0A4W2CHX7 A0A4W2CHX7 BIRC3 BIRC3 A0A4W2CFU3 A0A4W2CFU3 MAP3K7 MAP3K7 MAPK12 MAPK12 LAMA4 LAMA4 A0A4W2CCT2 A0A4W2CCT2 BAD BAD GNAO1 GNAO1 PIK3R5 PIK3R5 LAMB3 LAMB3 TLR2 TLR2 A0A4W2C1X2 A0A4W2C1X2 A0A4W2C164 A0A4W2C164 HLA-DOB HLA-DOB MAPK11 MAPK11 HLA-DRA HLA-DRA HLA-DQB1 HLA-DQB1 SOCS1 SOCS1 LAMB2 LAMB2 A0A4W2BXT5 A0A4W2BXT5 IKBKB IKBKB BCL2 BCL2 LAMA1 LAMA1 A0A4W2BS34 A0A4W2BS34 CIITA CIITA A0A4W2BM53 A0A4W2BM53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (485 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
A0A4W2IDQ2Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (461 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
MYD88MYD88 innate immune signal transduction adaptor. (384 aa)
NFKB1Nuclear factor kappa B subunit 1. (974 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
LOC113881562Ig-like domain-containing protein; Belongs to the MHC class II family. (253 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
A0A4W2H7Y7BH4_2 domain-containing protein. (195 aa)
BCL2L1BH4_2 domain-containing protein. (233 aa)
IL10RAInterleukin 10 receptor subunit alpha. (580 aa)
JAK1Tyrosine-protein kinase. (1110 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
A0A4W2G4L9Uncharacterized protein. (148 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
LOC113891379Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (260 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (650 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
GNAI2G protein subunit alpha i2. (436 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (208 aa)
A0A4W2F3V8Uncharacterized protein. (718 aa)
LDLRLow density lipoprotein receptor. (845 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (639 aa)
IFNGR2Interferon gamma receptor 2. (376 aa)
IL10RBInterleukin 10 receptor subunit beta. (387 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (240 aa)
LOC113901903Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
GNAI3G protein subunit alpha i3. (354 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
LY96Lymphocyte antigen 96. (160 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
A0A4W2EDY1Ig-like domain-containing protein. (318 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
LAMC3Laminin subunit gamma 3. (1577 aa)
NFKBIBNFKB inhibitor beta. (357 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CD40CD40 molecule. (280 aa)
LAMA3Laminin subunit alpha 3. (3334 aa)
A0A4W2E8M1BH4_2 domain-containing protein. (173 aa)
A0A4W2E7C9TNF receptor-associated factor. (411 aa)
LAMC2Laminin subunit gamma 2. (1191 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (756 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
STAT1Signal transducer and activator of transcription. (821 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (505 aa)
LOC113881774Ig-like domain-containing protein. (304 aa)
TNFRSF1ATNF receptor superfamily member 1A. (471 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
LOC113888945Uncharacterized protein. (623 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (297 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1156 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
LAMB1Laminin subunit beta 1. (1786 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1171 aa)
GNAI1G protein subunit alpha i1. (417 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (747 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
A0A4W2D608BH4_2 domain-containing protein. (238 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (636 aa)
A0A4W2D4T7Uncharacterized protein. (356 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
IFNGR1Interferon gamma receptor 1. (500 aa)
BIRC7Baculoviral IAP repeat containing 7. (293 aa)
C7orf31Chromosome 7 open reading frame 31. (584 aa)
A0A4W2CR26TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
A0A4W2CJ16Uncharacterized protein. (252 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
A0A4W2CHX7BH4_2 domain-containing protein. (233 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
A0A4W2CFU3Ig-like domain-containing protein. (259 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
LAMA4Laminin subunit alpha 4. (1824 aa)
A0A4W2CCT2Uncharacterized protein. (760 aa)
BADBCL2 associated agonist of cell death. (168 aa)
GNAO1G protein subunit alpha o1. (377 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (893 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (861 aa)
A0A4W2C1X2Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
A0A4W2C164Uncharacterized protein; Belongs to the heat shock protein 70 family. (715 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (271 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (253 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (269 aa)
SOCS1Suppressor of cytokine signaling 1. (224 aa)
LAMB2Laminin subunit beta 2. (1802 aa)
A0A4W2BXT5Ig-like domain-containing protein. (260 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
LAMA1Laminin subunit alpha 1. (3131 aa)
A0A4W2BS34Uncharacterized protein. (147 aa)
CIITAClass II major histocompatibility complex transactivator. (1206 aa)
A0A4W2BM53Uncharacterized protein. (103 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
Server load: low (34%) [HD]