STRINGSTRING
IL1B IL1B TGFB2 TGFB2 PRKACB PRKACB PRKCA PRKCA PRKACA PRKACA SERPINB13 SERPINB13 LAMA4 LAMA4 A0A4W2CCT2 A0A4W2CCT2 LOC113879868 LOC113879868 A0A4W2CAS0 A0A4W2CAS0 A0A4W2CAP7 A0A4W2CAP7 A0A4W2CAP3 A0A4W2CAP3 SMTNL2 SMTNL2 PIK3R1 PIK3R1 LAMB3 LAMB3 TLR2 TLR2 CASP3 CASP3 A0A4W2BUZ7 A0A4W2BUZ7 GNAL GNAL A0A4W2BVW3 A0A4W2BVW3 A0A4W2BWE6 A0A4W2BWE6 LOC113882932 LOC113882932 LAMB2 LAMB2 RELA RELA GNA11 GNA11 RAB5B RAB5B COL1A2 COL1A2 PIK3R2 PIK3R2 RAB7B RAB7B GNAQ GNAQ C9 C9 COL1A1 COL1A1 RAB5A RAB5A A0A4W2F3V8 A0A4W2F3V8 COL3A1 COL3A1 ITGB2 ITGB2 C8A C8A A0A4W2F014 A0A4W2F014 IL6 IL6 PIK3R3 PIK3R3 PRDX1 PRDX1 CXCL8 CXCL8 IL12A IL12A RAB17 RAB17 ARG2 ARG2 ACTN1 ACTN1 CSF2 CSF2 TGFB3 TGFB3 PRKCB PRKCB COL4A1 COL4A1 IFNG IFNG TNF TNF IL1R2 IL1R2 IL1R1 IL1R1 DCLK2 DCLK2 RAB5C RAB5C PRKCG PRKCG ARG1 ARG1 LAMC3 LAMC3 A0A4W2EA01 A0A4W2EA01 ADCY1 ADCY1 LAMA3 LAMA3 PLCB4 PLCB4 A0A4W2E8A5 A0A4W2E8A5 FN1 FN1 LAMC2 LAMC2 A0A4W2E3R5 A0A4W2E3R5 ACTN4 ACTN4 IL12B IL12B A0A4W2DYX0 A0A4W2DYX0 A0A4W2DY83 A0A4W2DY83 PIK3CB PIK3CB SMTN SMTN A0A4W2DX45 A0A4W2DX45 A0A4W2DX14 A0A4W2DX14 SPECC1 SPECC1 LOC113894385 LOC113894385 NOS2 NOS2 PIK3CA PIK3CA C8G C8G LAMB1 LAMB1 TRANK1 TRANK1 C8B C8B A0A4W2DEI2 A0A4W2DEI2 LOC113888813 LOC113888813 CD1E CD1E LOC113884529 LOC113884529 A0A4W2DEB0 A0A4W2DEB0 CD14 CD14 A0A4W2DC91 A0A4W2DC91 TLR4 TLR4 SMTNL1 SMTNL1 A0A4W2D326 A0A4W2D326 GNAS GNAS PLCB2 PLCB2 COL4A2 COL4A2 GNA14 GNA14 COL4A3 COL4A3 PIK3CD PIK3CD MFF MFF COL4A4 COL4A4 PTK2 PTK2 LAMA2 LAMA2 A0A4W2CJ16 A0A4W2CJ16 TGFB1 TGFB1 PLCB1 PLCB1 GNA15 GNA15 A0A4W2BXW7 A0A4W2BXW7 SERPINB8 SERPINB8 HSPB1 HSPB1 SERPINB9 SERPINB9 RAB7A RAB7A LAMA1 LAMA1 PLCB3 PLCB3 LOC113881268 LOC113881268 LOC113881571 LOC113881571 A0A4W2BTN1 A0A4W2BTN1 A0A4W2BTN2 A0A4W2BTN2 VCL VCL LOC113888750 LOC113888750 LAMC1 LAMC1 A0A4W2ILH9 A0A4W2ILH9 NFKB1 NFKB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (367 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
SERPINB13Serpin family B member 13; Belongs to the serpin family. (395 aa)
LAMA4Laminin subunit alpha 4. (1824 aa)
A0A4W2CCT2Uncharacterized protein. (760 aa)
LOC113879868Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
A0A4W2CAS0Ig-like domain-containing protein. (223 aa)
A0A4W2CAP7Ig-like domain-containing protein. (213 aa)
A0A4W2CAP3Ig-like domain-containing protein. (182 aa)
SMTNL2Smoothelin like 2. (458 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (861 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
A0A4W2BUZ7SERPIN domain-containing protein; Belongs to the serpin family. (86 aa)
GNALG protein subunit alpha L. (452 aa)
A0A4W2BVW3Ig-like domain-containing protein. (218 aa)
A0A4W2BWE6Ig-like domain-containing protein. (204 aa)
LOC113882932SERPIN domain-containing protein; Belongs to the serpin family. (389 aa)
LAMB2Laminin subunit beta 2. (1802 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
GNA11G protein subunit alpha 11. (359 aa)
RAB5BRAB5B, member RAS oncogene family. (215 aa)
COL1A2Collagen type I alpha 2 chain. (1364 aa)
PIK3R2Uncharacterized protein. (724 aa)
RAB7BRAB7B, member RAS oncogene family. (200 aa)
GNAQG protein subunit alpha q. (359 aa)
C9Complement C9. (548 aa)
COL1A1Collagen type I alpha 1 chain. (1584 aa)
RAB5AUncharacterized protein. (215 aa)
A0A4W2F3V8Uncharacterized protein. (718 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
ITGB2Integrin beta. (769 aa)
C8AComplement C8 alpha chain. (589 aa)
A0A4W2F014Ig-like domain-containing protein. (330 aa)
IL6Interleukin 6. (208 aa)
PIK3R3Uncharacterized protein. (461 aa)
PRDX1Thioredoxin domain-containing protein. (199 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (240 aa)
RAB17RAB17, member RAS oncogene family. (233 aa)
ARG2Arginase 2; Belongs to the arginase family. (462 aa)
ACTN1Actinin alpha 1. (962 aa)
CSF2Colony stimulating factor 2. (143 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
IL1R2Interleukin 1 receptor type 2. (400 aa)
IL1R1Interleukin 1 receptor type 1. (573 aa)
DCLK2Doublecortin like kinase 2. (767 aa)
RAB5CUncharacterized protein. (216 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (771 aa)
ARG1Arginase. (322 aa)
LAMC3Laminin subunit gamma 3. (1577 aa)
A0A4W2EA01Uncharacterized protein. (48 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1197 aa)
LAMA3Laminin subunit alpha 3. (3334 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1218 aa)
A0A4W2E8A5Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (304 aa)
FN1Fibronectin 1. (2601 aa)
LAMC2Laminin subunit gamma 2. (1191 aa)
A0A4W2E3R51-cysPrx_C domain-containing protein. (92 aa)
ACTN4Actinin alpha 4. (933 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
A0A4W2DYX0IGc1 domain-containing protein. (287 aa)
A0A4W2DY83SERPIN domain-containing protein; Belongs to the serpin family. (397 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
SMTNSmoothelin. (906 aa)
A0A4W2DX45Ig-like domain-containing protein. (167 aa)
A0A4W2DX14Ig-like domain-containing protein. (160 aa)
SPECC1Sperm antigen with calponin homology and coiled-coil domains 1. (1094 aa)
LOC113894385C-X-C motif chemokine. (104 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1156 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
C8GComplement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (202 aa)
LAMB1Laminin subunit beta 1. (1786 aa)
TRANK1Tetratricopeptide repeat and ankyrin repeat containing 1. (2969 aa)
C8BComplement C8 beta chain. (596 aa)
A0A4W2DEI2Ig-like domain-containing protein. (347 aa)
LOC113888813Ig-like domain-containing protein. (418 aa)
CD1ECD1e molecule. (393 aa)
LOC113884529Ig-like domain-containing protein. (333 aa)
A0A4W2DEB0IGc1 domain-containing protein. (334 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (373 aa)
A0A4W2DC91Uncharacterized protein. (241 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
SMTNL1Smoothelin like 1. (471 aa)
A0A4W2D326Uncharacterized protein. (165 aa)
GNASGNAS complex locus. (1004 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1226 aa)
COL4A2Collagen type IV alpha 2 chain. (1824 aa)
GNA14G protein subunit alpha 14. (355 aa)
COL4A3Collagen type IV alpha 3 chain. (1649 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
MFFMitochondrial fission factor. (409 aa)
COL4A4Collagen type IV alpha 4 chain. (1689 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1139 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
A0A4W2CJ16Uncharacterized protein. (252 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNA15G protein subunit alpha 15. (374 aa)
A0A4W2BXW7SERPIN domain-containing protein; Belongs to the serpin family. (380 aa)
SERPINB8Serpin family B member 8; Belongs to the serpin family. (398 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (216 aa)
SERPINB9Serpin family B member 9; Belongs to the serpin family. (383 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
LAMA1Laminin subunit alpha 1. (3131 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
LOC113881268SERPIN domain-containing protein; Belongs to the serpin family. (405 aa)
LOC113881571SERPIN domain-containing protein; Belongs to the serpin family. (466 aa)
A0A4W2BTN1Uncharacterized protein. (508 aa)
A0A4W2BTN2Ig-like domain-containing protein. (130 aa)
VCLVinculin. (1134 aa)
LOC113888750SERPIN domain-containing protein; Belongs to the serpin family. (391 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
A0A4W2ILH9Uncharacterized protein. (72 aa)
NFKB1Nuclear factor kappa B subunit 1. (974 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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