STRINGSTRING
MAPK11 MAPK11 RNF7 RNF7 CASP8 CASP8 RBX1 RBX1 AP1M2 AP1M2 A0A4W2IG83 A0A4W2IG83 NFKBIA NFKBIA A0A4W2IDQ2 A0A4W2IDQ2 LOC113896989 LOC113896989 IRAK4 IRAK4 MAPK3 MAPK3 A0A4W2I9W6 A0A4W2I9W6 A0A4W2I9K4 A0A4W2I9K4 A0A4W2I9H2 A0A4W2I9H2 MYD88 MYD88 CDK1 CDK1 NFKB1 NFKB1 PRKCB PRKCB FBXW11 FBXW11 A0A4W2I5C3 A0A4W2I5C3 JUN JUN PAK1 PAK1 WEE1 WEE1 CFL1 CFL1 MAP2K7 MAP2K7 HRAS HRAS A0A4W2H7Y7 A0A4W2H7Y7 GNG5 GNG5 BAX BAX AP1G1 AP1G1 A0A4W2GZ03 A0A4W2GZ03 A0A4W2GYG4 A0A4W2GYG4 RIPK1 RIPK1 BCL2L1 BCL2L1 LOC113897795 LOC113897795 LOC113897811 LOC113897811 A0A4W2GSS9 A0A4W2GSS9 NFATC3 NFATC3 TAB2 TAB2 TRADD TRADD PRKCA PRKCA MAPK10 MAPK10 A0A4W2G4L9 A0A4W2G4L9 RELA RELA AP1M1 AP1M1 LOC113891379 LOC113891379 GNA11 GNA11 GNG7 GNG7 CNTD2 CNTD2 MAP2K2 MAP2K2 PIK3R2 PIK3R2 GNG11 GNG11 AKT1 AKT1 A0A4W2FLF9 A0A4W2FLF9 GNAQ GNAQ CUL1 CUL1 CHUK CHUK GNAI2 GNAI2 SKP1 SKP1 DCAF1 DCAF1 PLCG2 PLCG2 MAPK9 MAPK9 CD247 CD247 A0A4W2F2V9 A0A4W2F2V9 A0A4W2F2N7 A0A4W2F2N7 PPP3CA PPP3CA A0A4W2F1Y8 A0A4W2F1Y8 CXCR4 CXCR4 CUL4B CUL4B RAC2 RAC2 TMEM173 TMEM173 PLVAP PLVAP PIK3R3 PIK3R3 LOC113901903 LOC113901903 PTK2B PTK2B GNB4 GNB4 CALML4 CALML4 A0A4W2ES87 A0A4W2ES87 A0A4W2ES53 A0A4W2ES53 A0A4W2ES23 A0A4W2ES23 GNAI3 GNAI3 A0A4W2ERP9 A0A4W2ERP9 A0A4W2ERN6 A0A4W2ERN6 A0A4W2ERJ9 A0A4W2ERJ9 A0A4W2ERJ1 A0A4W2ERJ1 A0A4W2ERG5 A0A4W2ERG5 A0A4W2ERF0 A0A4W2ERF0 A0A4W2EQH2 A0A4W2EQH2 A0A4W2EQG3 A0A4W2EQG3 A0A4W2EQB9 A0A4W2EQB9 A0A4W2EQA0 A0A4W2EQA0 A0A4W2EQ96 A0A4W2EQ96 A0A4W2EQ07 A0A4W2EQ07 A0A4W2EPY6 A0A4W2EPY6 LOC113899279 LOC113899279 PLCG1 PLCG1 A0A4W2EMM2 A0A4W2EMM2 A0A4W2EML3 A0A4W2EML3 A0A4W2EML2 A0A4W2EML2 LOC113897812 LOC113897812 A0A4W2EIV4 A0A4W2EIV4 PAK6 PAK6 PDIA3 PDIA3 CCNB2 CCNB2 TNF TNF MAP2K3 MAP2K3 A0A4W2EF48 A0A4W2EF48 TAPBP TAPBP PRKCG PRKCG AKT3 AKT3 TNFRSF1B TNFRSF1B FASLG FASLG CFL2 CFL2 A0A4W2E8M1 A0A4W2E8M1 ELOC ELOC GNB1 GNB1 A0A4W2E7C9 A0A4W2E7C9 A0A4W2E769 A0A4W2E769 CGAS CGAS GNG8 GNG8 TRIM6 TRIM6 CCNB1 CCNB1 MAP2K6 MAP2K6 GNB3 GNB3 A0A4W2E497 A0A4W2E497 AP1B1 AP1B1 PAK4 PAK4 TAB1 TAB1 A0A4W2DYV7 A0A4W2DYV7 TNFRSF1A TNFRSF1A PIK3CB PIK3CB KRAS KRAS A0A4W2DX15 A0A4W2DX15 LOC113882059 LOC113882059 A0A4W2DW81 A0A4W2DW81 A0A4W2DVS8 A0A4W2DVS8 A0A4W2DUV7 A0A4W2DUV7 MAPK13 MAPK13 PPP3CC PPP3CC ATM ATM A0A4W2DRK4 A0A4W2DRK4 CHEK1 CHEK1 LIMK1 LIMK1 CRK CRK ERAS ERAS A0A4W2DQK1 A0A4W2DQK1 PIK3CA PIK3CA CCR5 CCR5 NRAS NRAS A0A4W2DMZ8 A0A4W2DMZ8 A0A4W2DMM0 A0A4W2DMM0 TRBV24-1 TRBV24-1 NFATC4 NFATC4 GNAI1 GNAI1 A0A4W2DMB6 A0A4W2DMB6 A0A4W2DLH5 A0A4W2DLH5 FOS FOS PAK2 PAK2 A0A4W2DK85 A0A4W2DK85 A0A4W2DK77 A0A4W2DK77 A0A4W2DJH4 A0A4W2DJH4 ATR ATR A0A4W2DHR7 A0A4W2DHR7 LOC113896117 LOC113896117 CDC25C CDC25C A0A4W2DHH5 A0A4W2DHH5 CCDC194 CCDC194 A0A4W2DGC7 A0A4W2DGC7 A0A4W2DEY8 A0A4W2DEY8 ITPR2 ITPR2 A0A4W2DBM4 A0A4W2DBM4 GNGT1 GNGT1 A0A4W2D7C1 A0A4W2D7C1 A0A4W2D781 A0A4W2D781 A0A4W2D760 A0A4W2D760 A0A4W2D724 A0A4W2D724 A0A4W2D709 A0A4W2D709 A0A4W2D704 A0A4W2D704 A0A4W2D608 A0A4W2D608 GNG10 GNG10 A0A4W2D5P0 A0A4W2D5P0 A0A4W2D5H8 A0A4W2D5H8 A0A4W2D5G0 A0A4W2D5G0 A0A4W2D5F7 A0A4W2D5F7 A0A4W2D597 A0A4W2D597 A0A4W2D552 A0A4W2D552 A0A4W2D547 A0A4W2D547 A0A4W2D520 A0A4W2D520 MAPK8 MAPK8 MAP2K1 MAP2K1 CSDE1 CSDE1 CASP9 CASP9 TLR4 TLR4 A0A4W2D3G7 A0A4W2D3G7 CALM1 CALM1 A0A4W2D2W9 A0A4W2D2W9 A0A4W2D2T1 A0A4W2D2T1 A0A4W2D2S8 A0A4W2D2S8 A0A4W2D2S0 A0A4W2D2S0 A0A4W2D2R2 A0A4W2D2R2 A0A4W2D2L8 A0A4W2D2L8 AP1G2 AP1G2 LOC113905598 LOC113905598 LOC113905592 LOC113905592 A0A4W2D155 A0A4W2D155 A0A4W2D0I4 A0A4W2D0I4 A0A4W2D0G3 A0A4W2D0G3 A0A4W2D0E0 A0A4W2D0E0 A0A4W2D0D6 A0A4W2D0D6 A0A4W2D095 A0A4W2D095 A0A4W2D056 A0A4W2D056 WEE2 WEE2 A0A4W2CX00 A0A4W2CX00 A0A4W2CWV7 A0A4W2CWV7 A0A4W2CWS2 A0A4W2CWS2 SAMHD1 SAMHD1 A0A4W2CWK4 A0A4W2CWK4 PAK5 PAK5 TBK1 TBK1 GNB5 GNB5 MTOR MTOR GNG2 GNG2 PIK3CD PIK3CD C7orf31 C7orf31 A0A4W2CR26 A0A4W2CR26 CUL4A CUL4A CRKL CRKL MAPK1 MAPK1 CD4 CD4 A0A4W2CPD5 A0A4W2CPD5 NFATC2 NFATC2 AP1S3 AP1S3 IRF3 IRF3 PTK2 PTK2 BID BID A0A4W2CK57 A0A4W2CK57 LPXN LPXN AKT2 AKT2 A0A4W2CHX7 A0A4W2CHX7 MAP3K7 MAP3K7 MAPK12 MAPK12 CCDC125 CCDC125 FADD FADD RAC1 RAC1 BAD BAD GNAO1 GNAO1 PIK3R1 PIK3R1 RAC3 RAC3 PXN PXN LIMK2 LIMK2 A0A4W2C624 A0A4W2C624 A0A4W2C618 A0A4W2C618 A0A4W2C595 A0A4W2C595 TRAF5 TRAF5 FAS FAS BTRC BTRC A0A4W2C3V7 A0A4W2C3V7 TLR2 TLR2 A0A4W2C2X4 A0A4W2C2X4 LOC113882062 LOC113882062 LOC113881805 LOC113881805 A0A4W2C1N1 A0A4W2C1N1 CASP3 CASP3 TAP1 TAP1 LOC113888607 LOC113888607 GNG4 GNG4 ITPR3 ITPR3 BAK1 BAK1 LOC113881324 LOC113881324 CD3D CD3D CUL5 CUL5 A0A4W2BX47 A0A4W2BX47 IKBKB IKBKB BCL2 BCL2 PPP3CB PPP3CB RPS6KB2 RPS6KB2 CD3E CD3E A0A4W2BTG3 A0A4W2BTG3 TRAF2 TRAF2 A0A4W2BSK9 A0A4W2BSK9 DDB1 DDB1 RAF1 RAF1 RPS6KB1 RPS6KB1 A0A4W2BS34 A0A4W2BS34 GNG3 GNG3 GNB2 GNB2 ELOB ELOB ITPR1 ITPR1 GNG13 GNG13 AP1S1 AP1S1 A0A4W2BK72 A0A4W2BK72
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK11Mitogen-activated protein kinase. (364 aa)
RNF7Ring finger protein 7. (113 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (485 aa)
RBX1RING-type domain-containing protein. (128 aa)
AP1M2Adaptor related protein complex 1 subunit mu 2; Belongs to the adaptor complexes medium subunit family. (503 aa)
A0A4W2IG83Ubiquitin-like domain-containing protein. (118 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
A0A4W2IDQ2Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC113896989Uncharacterized protein. (186 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (461 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
A0A4W2I9W6Ig-like domain-containing protein. (167 aa)
A0A4W2I9K4Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (58 aa)
A0A4W2I9H2Ig-like domain-containing protein. (102 aa)
MYD88MYD88 innate immune signal transduction adaptor. (384 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
NFKB1Nuclear factor kappa B subunit 1. (974 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
A0A4W2I5C3Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (70 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
WEE1Wee1-like protein kinase. (646 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (166 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (658 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
A0A4W2H7Y7BH4_2 domain-containing protein. (195 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
AP1G1AP-1 complex subunit gamma. (825 aa)
A0A4W2GZ03Ubiquitin-like domain-containing protein. (113 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (669 aa)
BCL2L1BH4_2 domain-containing protein. (233 aa)
LOC113897795Uncharacterized protein. (189 aa)
LOC113897811Uncharacterized protein. (186 aa)
A0A4W2GSS9Uncharacterized protein. (47 aa)
NFATC3Nuclear factor of activated T cells 3. (1073 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
A0A4W2G4L9Uncharacterized protein. (148 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
AP1M1Adaptor related protein complex 1 subunit mu 1; Belongs to the adaptor complexes medium subunit family. (435 aa)
LOC113891379Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
GNA11G protein subunit alpha 11. (359 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CNTD2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (332 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
PIK3R2Uncharacterized protein. (724 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
A0A4W2FLF9RING-type domain-containing protein. (108 aa)
GNAQG protein subunit alpha q. (359 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
GNAI2G protein subunit alpha i2. (436 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1507 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CD247CD247 molecule. (166 aa)
A0A4W2F2V9Uncharacterized protein. (63 aa)
A0A4W2F2N7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (198 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
A0A4W2F1Y8CYCLIN domain-containing protein; Belongs to the cyclin family. (250 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
CUL4BCullin 4B; Belongs to the cullin family. (734 aa)
RAC2Rac family small GTPase 2. (209 aa)
TMEM173Transmembrane protein 173. (484 aa)
PLVAPPlasmalemma vesicle associated protein. (442 aa)
PIK3R3Uncharacterized protein. (461 aa)
LOC113901903Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1008 aa)
GNB4G protein subunit beta 4. (340 aa)
CALML4Calmodulin like 4. (153 aa)
A0A4W2ES87IGv domain-containing protein. (140 aa)
A0A4W2ES53Ig-like domain-containing protein. (222 aa)
A0A4W2ES23Uncharacterized protein. (128 aa)
GNAI3G protein subunit alpha i3. (354 aa)
A0A4W2ERP9Ig-like domain-containing protein. (331 aa)
A0A4W2ERN6Ig-like domain-containing protein. (127 aa)
A0A4W2ERJ9Ig-like domain-containing protein. (181 aa)
A0A4W2ERJ1Ig-like domain-containing protein. (174 aa)
A0A4W2ERG5Ig-like domain-containing protein. (136 aa)
A0A4W2ERF0Ig-like domain-containing protein. (150 aa)
A0A4W2EQH2Ig-like domain-containing protein. (102 aa)
A0A4W2EQG3Ig-like domain-containing protein. (217 aa)
A0A4W2EQB9Ig-like domain-containing protein. (189 aa)
A0A4W2EQA0Ig-like domain-containing protein. (207 aa)
A0A4W2EQ96Ig-like domain-containing protein. (157 aa)
A0A4W2EQ07Ig-like domain-containing protein. (95 aa)
A0A4W2EPY6Ig-like domain-containing protein. (102 aa)
LOC113899279Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
A0A4W2EMM2Uncharacterized protein. (187 aa)
A0A4W2EML3Uncharacterized protein. (189 aa)
A0A4W2EML2Uncharacterized protein. (186 aa)
LOC113897812Uncharacterized protein. (186 aa)
A0A4W2EIV4EF-hand domain-containing protein; Belongs to the calmodulin family. (87 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
CCNB2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (398 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
A0A4W2EF48Uncharacterized protein. (490 aa)
TAPBPTAP binding protein. (494 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (771 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
TNFRSF1BUncharacterized protein. (588 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (277 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
A0A4W2E8M1BH4_2 domain-containing protein. (173 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
GNB1G protein subunit beta 1. (358 aa)
A0A4W2E7C9TNF receptor-associated factor. (411 aa)
A0A4W2E769Ubiquitin-like domain-containing protein. (118 aa)
CGASCyclic GMP-AMP synthase. (513 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
TRIM6Tripartite motif containing 6. (613 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (427 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
GNB3G protein subunit beta 3. (356 aa)
A0A4W2E497MHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (243 aa)
AP1B1AP complex subunit beta. (999 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (505 aa)
A0A4W2DYV7Uncharacterized protein. (202 aa)
TNFRSF1ATNF receptor superfamily member 1A. (471 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
A0A4W2DX15Ig-like domain-containing protein. (199 aa)
LOC113882059Ig-like domain-containing protein; Belongs to the MHC class I family. (366 aa)
A0A4W2DW81Ig-like domain-containing protein; Belongs to the MHC class I family. (343 aa)
A0A4W2DVS8Ig-like domain-containing protein. (529 aa)
A0A4W2DUV7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (87 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
PPP3CCSerine/threonine-protein phosphatase. (531 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
A0A4W2DRK4IGv domain-containing protein. (83 aa)
CHEK1Checkpoint kinase 1. (677 aa)
LIMK1LIM domain kinase 1. (778 aa)
CRKCRK proto-oncogene, adaptor protein. (376 aa)
ERASES cell expressed Ras. (185 aa)
A0A4W2DQK1B30.2/SPRY domain-containing protein. (217 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
A0A4W2DMZ8Skp1_POZ domain-containing protein. (72 aa)
A0A4W2DMM0IGv domain-containing protein. (177 aa)
TRBV24-1T cell receptor beta variable 24-1. (97 aa)
NFATC4Nuclear factor of activated T cells 4. (979 aa)
GNAI1G protein subunit alpha i1. (417 aa)
A0A4W2DMB6Ig-like domain-containing protein. (172 aa)
A0A4W2DLH5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (103 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PAK2Non-specific serine/threonine protein kinase. (600 aa)
A0A4W2DK85Ig-like domain-containing protein. (111 aa)
A0A4W2DK77Ig-like domain-containing protein. (193 aa)
A0A4W2DJH4Uncharacterized protein. (189 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
A0A4W2DHR7Uncharacterized protein. (266 aa)
LOC113896117Uncharacterized protein. (231 aa)
CDC25CCell division cycle 25C. (477 aa)
A0A4W2DHH5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CCDC194Coiled-coil domain containing 194. (236 aa)
A0A4W2DGC7Uncharacterized protein. (186 aa)
A0A4W2DEY8Clat_adaptor_s domain-containing protein. (87 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
A0A4W2DBM4Ig-like domain-containing protein; Belongs to the MHC class I family. (475 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (134 aa)
A0A4W2D7C1Ig-like domain-containing protein. (127 aa)
A0A4W2D781Ig-like domain-containing protein. (137 aa)
A0A4W2D760Ig-like domain-containing protein. (128 aa)
A0A4W2D724Ig-like domain-containing protein. (177 aa)
A0A4W2D709Ig-like domain-containing protein. (165 aa)
A0A4W2D704Ig-like domain-containing protein. (150 aa)
A0A4W2D608BH4_2 domain-containing protein. (238 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
A0A4W2D5P0DUF1968 domain-containing protein. (225 aa)
A0A4W2D5H8Ig-like domain-containing protein. (237 aa)
A0A4W2D5G0Ig-like domain-containing protein. (106 aa)
A0A4W2D5F7Ig-like domain-containing protein. (182 aa)
A0A4W2D597Ig-like domain-containing protein. (112 aa)
A0A4W2D552Ig-like domain-containing protein. (153 aa)
A0A4W2D547Ig-like domain-containing protein. (146 aa)
A0A4W2D520Ig-like domain-containing protein. (202 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
CSDE1Cold shock domain containing E1. (844 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
A0A4W2D3G7Ubiquitin-like domain-containing protein. (66 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (365 aa)
A0A4W2D2W9Ig-like domain-containing protein. (261 aa)
A0A4W2D2T1Ig-like domain-containing protein. (127 aa)
A0A4W2D2S8Ig-like domain-containing protein. (127 aa)
A0A4W2D2S0Ig-like domain-containing protein. (174 aa)
A0A4W2D2R2Ig-like domain-containing protein. (118 aa)
A0A4W2D2L8Ig-like domain-containing protein. (147 aa)
AP1G2AP-1 complex subunit gamma. (975 aa)
LOC113905598Uncharacterized protein. (511 aa)
LOC113905592Uncharacterized protein. (488 aa)
A0A4W2D155Uncharacterized protein. (153 aa)
A0A4W2D0I4Ig-like domain-containing protein. (112 aa)
A0A4W2D0G3Ig-like domain-containing protein. (151 aa)
A0A4W2D0E0Ig-like domain-containing protein. (136 aa)
A0A4W2D0D6Ig-like domain-containing protein. (177 aa)
A0A4W2D095Ig-like domain-containing protein. (143 aa)
A0A4W2D056Ig-like domain-containing protein. (153 aa)
WEE2Wee1-like protein kinase. (566 aa)
A0A4W2CX00Uncharacterized protein. (189 aa)
A0A4W2CWV7Uncharacterized protein. (189 aa)
A0A4W2CWS2Uncharacterized protein. (154 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (608 aa)
A0A4W2CWK4Skp1_POZ domain-containing protein. (65 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
TBK1TANK binding kinase 1. (729 aa)
GNB5G protein subunit beta 5. (452 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (123 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
C7orf31Chromosome 7 open reading frame 31. (584 aa)
A0A4W2CR26TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
CUL4ACullin 4A; Belongs to the cullin family. (731 aa)
CRKLCRK like proto-oncogene, adaptor protein. (302 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
CD4CD4 molecule. (455 aa)
A0A4W2CPD5Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (109 aa)
NFATC2Nuclear factor of activated T cells 2. (914 aa)
AP1S3Adaptor related protein complex 1 subunit sigma 3. (251 aa)
IRF3Interferon regulatory factor 3. (417 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1139 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa)
A0A4W2CK57Ig-like domain-containing protein; Belongs to the MHC class I family. (375 aa)
LPXNLeupaxin. (399 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
A0A4W2CHX7BH4_2 domain-containing protein. (233 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
CCDC125Coiled-coil domain containing 125. (513 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (209 aa)
RAC1Rac family small GTPase 1. (257 aa)
BADBCL2 associated agonist of cell death. (168 aa)
GNAO1G protein subunit alpha o1. (377 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RAC3Rac family small GTPase 3. (258 aa)
PXNUncharacterized protein. (1066 aa)
LIMK2LIM domain kinase 2. (628 aa)
A0A4W2C624Ig-like domain-containing protein; Belongs to the MHC class I family. (327 aa)
A0A4W2C618Ig-like domain-containing protein; Belongs to the MHC class I family. (353 aa)
A0A4W2C595Ig-like domain-containing protein; Belongs to the MHC class I family. (325 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
FASFas cell surface death receptor. (323 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (616 aa)
A0A4W2C3V7CMP/dCMP-type deaminase domain-containing protein. (185 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (861 aa)
A0A4W2C2X4Ig-like domain-containing protein; Belongs to the MHC class I family. (356 aa)
LOC113882062Ig-like domain-containing protein; Belongs to the MHC class I family. (365 aa)
LOC113881805Ig-like domain-containing protein; Belongs to the MHC class I family. (374 aa)
A0A4W2C1N1MHC_I-like_Ag-recog domain-containing protein. (218 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (838 aa)
LOC113888607Uncharacterized protein. (189 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
LOC113881324Uncharacterized protein. (719 aa)
CD3DCD3d molecule. (167 aa)
CUL5Cullin 5; Belongs to the cullin family. (780 aa)
A0A4W2BX47Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (79 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
CD3ECD3e molecule. (197 aa)
A0A4W2BTG3Uncharacterized protein. (65 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
A0A4W2BSK9Uncharacterized protein. (784 aa)
DDB1Damage specific DNA binding protein 1. (1506 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
A0A4W2BS34Uncharacterized protein. (147 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNB2G protein subunit beta 2. (340 aa)
ELOBUncharacterized protein. (126 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
GNG13G protein subunit gamma 13. (67 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
A0A4W2BK72Uncharacterized protein. (172 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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