STRINGSTRING
TGFB3 TGFB3 APPL1 APPL1 CTNNB1 CTNNB1 A0A4W2BS34 A0A4W2BS34 RPS6KB1 RPS6KB1 RAF1 RAF1 MLH1 MLH1 SMAD2 SMAD2 RPS6KB2 RPS6KB2 BCL2 BCL2 DCC DCC BAK1 BAK1 CASP3 CASP3 RAC3 RAC3 PIK3R1 PIK3R1 BAD BAD APC APC RAC1 RAC1 EGFR EGFR PMAIP1 PMAIP1 AKT2 AKT2 TGFB1 TGFB1 AXIN2 AXIN2 GRB2 GRB2 TGFBR1 TGFBR1 MAPK1 MAPK1 C7orf31 C7orf31 PIK3CD PIK3CD MTOR MTOR GSK3B GSK3B A0A4W2CYF2 A0A4W2CYF2 BCL2L11 BCL2L11 CASP9 CASP9 CSDE1 CSDE1 MAP2K1 MAP2K1 MAPK8 MAPK8 POLK POLK AXIN1 AXIN1 FOS FOS GADD45B GADD45B NRAS NRAS PIK3CA PIK3CA SMAD4 SMAD4 ERAS ERAS KRAS KRAS PIK3CB PIK3CB RALGDS RALGDS LEF1 LEF1 MSH3 MSH3 BIRC5 BIRC5 MSH6 MSH6 TGFBR2 TGFBR2 RALA RALA CCND1 CCND1 AKT3 AKT3 SOS2 SOS2 CDKN1A CDKN1A BRAF BRAF SMAD3 SMAD3 LOC113901903 LOC113901903 APC2 APC2 AREG AREG PIK3R3 PIK3R3 RAC2 RAC2 GADD45A GADD45A MAPK9 MAPK9 TCF7 TCF7 RHOA RHOA RALB RALB AKT1 AKT1 PIK3R2 PIK3R2 MAP2K2 MAP2K2 LOC113891379 LOC113891379 TCF7L2 TCF7L2 A0A4W2G4L9 A0A4W2G4L9 MAPK10 MAPK10 MSH2 MSH2 BBC3 BBC3 EREG EREG A0A4W2GYG4 A0A4W2GYG4 BAX BAX MYC MYC HRAS HRAS TGFB2 TGFB2 TCF7L1 TCF7L1 DDB2 DDB2 TP53 TP53 JUN JUN EPGN EPGN MAPK3 MAPK3 SOS1 SOS1 A0A4W2IDQ2 A0A4W2IDQ2 TGFA TGFA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
CTNNB1Catenin beta 1. (774 aa)
A0A4W2BS34Uncharacterized protein. (147 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MLH1MutL homolog 1. (758 aa)
SMAD2Mothers against decapentaplegic homolog. (626 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
DCCDCC netrin 1 receptor. (1490 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
RAC3Rac family small GTPase 3. (258 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BADBCL2 associated agonist of cell death. (168 aa)
APCAPC regulator of WNT signaling pathway. (2912 aa)
RAC1Rac family small GTPase 1. (257 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
AXIN2Axin 2. (836 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
C7orf31Chromosome 7 open reading frame 31. (584 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
A0A4W2CYF2PWWP domain-containing protein. (159 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (195 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
CSDE1Cold shock domain containing E1. (844 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
POLKDNA polymerase kappa. (911 aa)
AXIN1Axin 1. (909 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
ERASES cell expressed Ras. (185 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
RALGDSUncharacterized protein. (1077 aa)
LEF1Lymphoid enhancer binding factor 1. (430 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1118 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
RALARAS like proto-oncogene A. (206 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (428 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LOC113901903Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
APC2APC regulator of WNT signaling pathway 2. (2264 aa)
AREGAmphiregulin. (247 aa)
PIK3R3Uncharacterized protein. (461 aa)
RAC2Rac family small GTPase 2. (209 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TCF7Transcription factor 7. (473 aa)
RHOARas homolog family member A. (193 aa)
RALBRAS like proto-oncogene B. (206 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
PIK3R2Uncharacterized protein. (724 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
LOC113891379Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TCF7L2Transcription factor 7 like 2. (652 aa)
A0A4W2G4L9Uncharacterized protein. (148 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
BBC3Uncharacterized protein. (193 aa)
EREGEpiregulin. (167 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TCF7L1Transcription factor 7 like 1. (588 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
EPGNEpithelial mitogen. (153 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
A0A4W2IDQ2Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TGFATransforming growth factor alpha. (228 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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