(77 nodes) Renal cell carcinoma network (Bos indicus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (805 aa)
	MAPK1	Mitogen-activated protein kinase. (634 aa)
	A0A4W2CPD5	Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (109 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	EPAS1	Endothelial PAS domain protein 1. (928 aa)
	TGFB1	Transforming growth factor beta 1. (443 aa)
	AKT2	AKT serine/threonine kinase 2. (603 aa)
	BAD	BCL2 associated agonist of cell death. (168 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	EP300	E1A binding protein p300. (2411 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
	A0A4W2BS34	Uncharacterized protein. (147 aa)
	ELOB	Uncharacterized protein. (126 aa)
	A0A4W2GYG4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	EGLN1	Uncharacterized protein. (420 aa)
	A0A4W2G4L9	Uncharacterized protein. (148 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
	PIK3R2	Uncharacterized protein. (724 aa)
	AKT1	Non-specific serine/threonine protein kinase. (747 aa)
	FLCN	UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
	A0A4W2FLF9	RING-type domain-containing protein. (108 aa)
	PIK3R3	Uncharacterized protein. (461 aa)
	SLC2A1	Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (530 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (302 aa)
	EGLN3	Egl-9 family hypoxia inducible factor 3. (239 aa)
	PAK6	Non-specific serine/threonine protein kinase. (681 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (161 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1384 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	AKT3	AKT serine/threonine kinase 3. (564 aa)
	CUL2	Cullin 2; Belongs to the cullin family. (744 aa)
	ELOC	Elongin C; Belongs to the SKP1 family. (112 aa)
	A0A4W2E769	Ubiquitin-like domain-containing protein. (118 aa)
	PAK4	Non-specific serine/threonine protein kinase. (593 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (394 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	A0A4W2DSW5	Uncharacterized protein. (191 aa)
	CRK	CRK proto-oncogene, adaptor protein. (376 aa)
	ERAS	ES cell expressed Ras. (185 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	A0A4W2DMZ8	Skp1_POZ domain-containing protein. (72 aa)
	PAK2	Non-specific serine/threonine protein kinase. (600 aa)
	CREBBP	CREB binding protein. (2435 aa)
	HGF	Hepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
	CDC42	Cell division cycle 42. (191 aa)
	PRCC	Proline rich mitotic checkpoint control factor. (492 aa)
	FH	Fumarate hydratase. (503 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1265 aa)
	A0A4W2D4V5	Uncharacterized protein. (607 aa)
	MAP2K1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
	CSDE1	Cold shock domain containing E1. (844 aa)
	A0A4W2D3G7	Ubiquitin-like domain-containing protein. (66 aa)
	PAK5	Non-specific serine/threonine protein kinase. (719 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
	TGFA	Transforming growth factor alpha. (228 aa)
	RBX1	RING-type domain-containing protein. (128 aa)
	A0A4W2IG83	Ubiquitin-like domain-containing protein. (118 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)
	ARNT2	Aryl hydrocarbon receptor nuclear translocator 2. (717 aa)
	EGLN2	Egl-9 family hypoxia inducible factor 2. (464 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (842 aa)
	GAB1	GRB2 associated binding protein 1. (751 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	RAP1B	Uncharacterized protein. (184 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	ETS1	ETS proto-oncogene 1, transcription factor. (485 aa)
	ARNT	Aryl hydrocarbon receptor nuclear translocator. (940 aa)
	A0A4W2GZ03	Ubiquitin-like domain-containing protein. (113 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2CPD5	A0A4W2D3G7	A0A4W2CPD5	A0A4W2D3G7	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Ubiquitin-like domain-containing protein.	0.880
A0A4W2CPD5	A0A4W2DSW5	A0A4W2CPD5	A0A4W2DSW5	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Uncharacterized protein.	0.968
A0A4W2CPD5	A0A4W2E769	A0A4W2CPD5	A0A4W2E769	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Ubiquitin-like domain-containing protein.	0.880
A0A4W2CPD5	A0A4W2FLF9	A0A4W2CPD5	A0A4W2FLF9	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	RING-type domain-containing protein.	0.915
A0A4W2CPD5	A0A4W2GZ03	A0A4W2CPD5	A0A4W2GZ03	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Ubiquitin-like domain-containing protein.	0.880
A0A4W2CPD5	A0A4W2IG83	A0A4W2CPD5	A0A4W2IG83	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Ubiquitin-like domain-containing protein.	0.878
A0A4W2CPD5	CUL2	A0A4W2CPD5	A0A4W2EAE8	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Cullin 2; Belongs to the cullin family.	0.978
A0A4W2CPD5	EGLN1	A0A4W2CPD5	A0A4W2GT70	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Uncharacterized protein.	0.479
A0A4W2CPD5	EGLN2	A0A4W2CPD5	A0A4W2HUV0	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Egl-9 family hypoxia inducible factor 2.	0.479
A0A4W2CPD5	EGLN3	A0A4W2CPD5	A0A4W2EIV2	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Egl-9 family hypoxia inducible factor 3.	0.482
A0A4W2CPD5	ELOB	A0A4W2CPD5	A0A4W2BP13	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Uncharacterized protein.	0.880
A0A4W2CPD5	EPAS1	A0A4W2CPD5	A0A4W2CKH9	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Endothelial PAS domain protein 1.	0.865
A0A4W2CPD5	HIF1A	A0A4W2CPD5	A0A4W2HED4	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Hypoxia inducible factor 1 subunit alpha.	0.943
A0A4W2CPD5	RBX1	A0A4W2CPD5	A0A4W2INA9	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	RING-type domain-containing protein.	0.915
A0A4W2D3G7	A0A4W2CPD5	A0A4W2D3G7	A0A4W2CPD5	Ubiquitin-like domain-containing protein.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.880
A0A4W2D3G7	A0A4W2DMZ8	A0A4W2D3G7	A0A4W2DMZ8	Ubiquitin-like domain-containing protein.	Skp1_POZ domain-containing protein.	0.880
A0A4W2D3G7	A0A4W2DSW5	A0A4W2D3G7	A0A4W2DSW5	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.912
A0A4W2D3G7	A0A4W2FLF9	A0A4W2D3G7	A0A4W2FLF9	Ubiquitin-like domain-containing protein.	RING-type domain-containing protein.	0.885
A0A4W2D3G7	A0A4W2IG83	A0A4W2D3G7	A0A4W2IG83	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.628
A0A4W2D3G7	CUL2	A0A4W2D3G7	A0A4W2EAE8	Ubiquitin-like domain-containing protein.	Cullin 2; Belongs to the cullin family.	0.954

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