STRINGSTRING
BRAF BRAF MAPK1 MAPK1 A0A4W2CPD5 A0A4W2CPD5 GRB2 GRB2 EPAS1 EPAS1 TGFB1 TGFB1 AKT2 AKT2 BAD BAD PIK3R1 PIK3R1 PDGFB PDGFB EP300 EP300 RAF1 RAF1 A0A4W2BS34 A0A4W2BS34 ELOB ELOB A0A4W2GYG4 A0A4W2GYG4 PTPN11 PTPN11 EGLN1 EGLN1 A0A4W2G4L9 A0A4W2G4L9 RAP1A RAP1A MAP2K2 MAP2K2 PIK3R2 PIK3R2 AKT1 AKT1 FLCN FLCN A0A4W2FLF9 A0A4W2FLF9 PIK3R3 PIK3R3 SLC2A1 SLC2A1 TGFB3 TGFB3 CRKL CRKL EGLN3 EGLN3 PAK6 PAK6 CDKN1A CDKN1A MET MET SOS2 SOS2 AKT3 AKT3 CUL2 CUL2 ELOC ELOC A0A4W2E769 A0A4W2E769 PAK4 PAK4 VEGFA VEGFA PIK3CB PIK3CB KRAS KRAS A0A4W2DSW5 A0A4W2DSW5 CRK CRK ERAS ERAS PIK3CA PIK3CA NRAS NRAS A0A4W2DMZ8 A0A4W2DMZ8 PAK2 PAK2 CREBBP CREBBP HGF HGF CDC42 CDC42 PRCC PRCC FH FH RAPGEF1 RAPGEF1 A0A4W2D4V5 A0A4W2D4V5 MAP2K1 MAP2K1 CSDE1 CSDE1 A0A4W2D3G7 A0A4W2D3G7 PAK5 PAK5 PIK3CD PIK3CD TGFA TGFA RBX1 RBX1 A0A4W2IG83 A0A4W2IG83 SOS1 SOS1 MAPK3 MAPK3 JUN JUN PAK1 PAK1 ARNT2 ARNT2 EGLN2 EGLN2 HIF1A HIF1A GAB1 GAB1 TGFB2 TGFB2 RAP1B RAP1B HRAS HRAS ETS1 ETS1 ARNT ARNT A0A4W2GZ03 A0A4W2GZ03
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
A0A4W2CPD5Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (109 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
EPAS1Endothelial PAS domain protein 1. (928 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
EP300E1A binding protein p300. (2411 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
A0A4W2BS34Uncharacterized protein. (147 aa)
ELOBUncharacterized protein. (126 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
EGLN1Uncharacterized protein. (420 aa)
A0A4W2G4L9Uncharacterized protein. (148 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
PIK3R2Uncharacterized protein. (724 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
A0A4W2FLF9RING-type domain-containing protein. (108 aa)
PIK3R3Uncharacterized protein. (461 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (530 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
CRKLCRK like proto-oncogene, adaptor protein. (302 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1384 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
CUL2Cullin 2; Belongs to the cullin family. (744 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
A0A4W2E769Ubiquitin-like domain-containing protein. (118 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (394 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
A0A4W2DSW5Uncharacterized protein. (191 aa)
CRKCRK proto-oncogene, adaptor protein. (376 aa)
ERASES cell expressed Ras. (185 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
A0A4W2DMZ8Skp1_POZ domain-containing protein. (72 aa)
PAK2Non-specific serine/threonine protein kinase. (600 aa)
CREBBPCREB binding protein. (2435 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
CDC42Cell division cycle 42. (191 aa)
PRCCProline rich mitotic checkpoint control factor. (492 aa)
FHFumarate hydratase. (503 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1265 aa)
A0A4W2D4V5Uncharacterized protein. (607 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
CSDE1Cold shock domain containing E1. (844 aa)
A0A4W2D3G7Ubiquitin-like domain-containing protein. (66 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
TGFATransforming growth factor alpha. (228 aa)
RBX1RING-type domain-containing protein. (128 aa)
A0A4W2IG83Ubiquitin-like domain-containing protein. (118 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (717 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (464 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RAP1BUncharacterized protein. (184 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (940 aa)
A0A4W2GZ03Ubiquitin-like domain-containing protein. (113 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
Server load: low (28%) [HD]