STRINGSTRING
TGFB3 TGFB3 BRAF BRAF CDK4 CDK4 CDKN1A CDKN1A AKT3 AKT3 CCND1 CCND1 RALA RALA STAT3 STAT3 TGFBR2 TGFBR2 A0A4W2E8M1 A0A4W2E8M1 STAT1 STAT1 VEGFA VEGFA RALGDS RALGDS ERBB2 ERBB2 PIK3CB PIK3CB KRAS KRAS SMAD4 SMAD4 PIK3CA PIK3CA RALBP1 RALBP1 GADD45B GADD45B CDC42 CDC42 POLK POLK A0A4W2D608 A0A4W2D608 MAPK8 MAPK8 MAP2K1 MAP2K1 CASP9 CASP9 RAD51 RAD51 MTOR MTOR PIK3CD PIK3CD MAPK1 MAPK1 TGFBR1 TGFBR1 TGFB1 TGFB1 AKT2 AKT2 A0A4W2CHX7 A0A4W2CHX7 A0A4W2CFU1 A0A4W2CFU1 PLD2 PLD2 EGFR EGFR RAC1 RAC1 BAD BAD PIK3R1 PIK3R1 RAC3 RAC3 BAK1 BAK1 IKBKB IKBKB RPS6KB2 RPS6KB2 SMAD2 SMAD2 RAF1 RAF1 RPS6KB1 RPS6KB1 A0A4W2BS34 A0A4W2BS34 BRCA2 BRCA2 E2F3 E2F3 TGFA TGFA MAPK3 MAPK3 NFKB1 NFKB1 TP53 TP53 RB1 RB1 DDB2 DDB2 TGFB2 TGFB2 E2F2 E2F2 E2F1 E2F1 A0A4W2H7Y7 A0A4W2H7Y7 BAX BAX A0A4W2GYG4 A0A4W2GYG4 BCL2L1 BCL2L1 JAK1 JAK1 MAPK10 MAPK10 A0A4W2G5Q0 A0A4W2G5Q0 A0A4W2G4L9 A0A4W2G4L9 RELA RELA PIK3R2 PIK3R2 CDK6 CDK6 AKT1 AKT1 RALB RALB CHUK CHUK MAPK9 MAPK9 GADD45A GADD45A RAC2 RAC2 PIK3R3 PIK3R3 PLD1 PLD1 SMAD3 SMAD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (428 aa)
RALARAS like proto-oncogene A. (206 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
A0A4W2E8M1BH4_2 domain-containing protein. (173 aa)
STAT1Signal transducer and activator of transcription. (821 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (394 aa)
RALGDSUncharacterized protein. (1077 aa)
ERBB2Erb-b2 receptor tyrosine kinase 2. (1710 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RALBP1RalA binding protein 1. (635 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
CDC42Cell division cycle 42. (191 aa)
POLKDNA polymerase kappa. (911 aa)
A0A4W2D608BH4_2 domain-containing protein. (238 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
A0A4W2CHX7BH4_2 domain-containing protein. (233 aa)
A0A4W2CFU1Protein kinase domain-containing protein. (79 aa)
PLD2Phospholipase. (1088 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
RAC1Rac family small GTPase 1. (257 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RAC3Rac family small GTPase 3. (258 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
SMAD2Mothers against decapentaplegic homolog. (626 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
A0A4W2BS34Uncharacterized protein. (147 aa)
BRCA2BRCA2 DNA repair associated. (3420 aa)
E2F3E2F transcription factor 3. (465 aa)
TGFATransforming growth factor alpha. (228 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
NFKB1Nuclear factor kappa B subunit 1. (974 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
RB1RB transcriptional corepressor 1. (928 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
E2F2E2F transcription factor 2. (437 aa)
E2F1E2F transcription factor 1. (437 aa)
A0A4W2H7Y7BH4_2 domain-containing protein. (195 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
BCL2L1BH4_2 domain-containing protein. (233 aa)
JAK1Tyrosine-protein kinase. (1110 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
A0A4W2G5Q0Protein kinase domain-containing protein. (79 aa)
A0A4W2G4L9Uncharacterized protein. (148 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
PIK3R2Uncharacterized protein. (724 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
RALBRAS like proto-oncogene B. (206 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
RAC2Rac family small GTPase 2. (209 aa)
PIK3R3Uncharacterized protein. (461 aa)
PLD1Phospholipase. (1126 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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