61 items (Bos indicus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (805 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (428 aa)
	LEF1	Lymphoid enhancer binding factor 1. (430 aa)
	ERBB2	Erb-b2 receptor tyrosine kinase 2. (1710 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	A0A4W2DS38	Uncharacterized protein. (409 aa)
	ERAS	ES cell expressed Ras. (185 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (160 aa)
	AXIN1	Axin 1. (909 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (747 aa)
	POLK	DNA polymerase kappa. (911 aa)
	MAP2K1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
	CSDE1	Cold shock domain containing E1. (844 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (452 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
	CDH1	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
	MAPK1	Mitogen-activated protein kinase. (634 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	AXIN2	Axin 2. (836 aa)
	ILK	Integrin linked kinase. (452 aa)
	AKT2	AKT serine/threonine kinase 2. (603 aa)
	FOXO3	Forkhead box O3. (617 aa)
	CTNNA2	Catenin alpha 2. (953 aa)
	EGFR	Receptor protein-tyrosine kinase. (1209 aa)
	APC	APC regulator of WNT signaling pathway. (2912 aa)
	BAD	BCL2 associated agonist of cell death. (168 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	ELK1	ETS transcription factor ELK1. (432 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	MLH1	MutL homolog 1. (758 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
	A0A4W2BS34	Uncharacterized protein. (147 aa)
	CTNNB1	Catenin beta 1. (774 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
	DDB2	Damage specific DNA binding protein 2. (426 aa)
	TCF7L1	Transcription factor 7 like 1. (588 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	A0A4W2GYG4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	CTNNA3	Catenin alpha 3. (895 aa)
	A0A4W2G4L9	Uncharacterized protein. (148 aa)
	TCF7L2	Transcription factor 7 like 2. (652 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
	PIK3R2	Uncharacterized protein. (724 aa)
	CTNNA1	Catenin alpha 1. (919 aa)
	AKT1	Non-specific serine/threonine protein kinase. (747 aa)
	TCF7	Transcription factor 7. (473 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (165 aa)
	PIK3R3	Uncharacterized protein. (461 aa)
	APC2	APC regulator of WNT signaling pathway 2. (2264 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (161 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	AKT3	AKT serine/threonine kinase 3. (564 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2DS38	AKT1	A0A4W2DS38	A0A4W2FNQ0	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.580
A0A4W2DS38	AKT2	A0A4W2DS38	A0A4W2CI15	Uncharacterized protein.	AKT serine/threonine kinase 2.	0.580
A0A4W2DS38	AKT3	A0A4W2DS38	A0A4W2EBH0	Uncharacterized protein.	AKT serine/threonine kinase 3.	0.580
A0A4W2DS38	FOXO3	A0A4W2DS38	A0A4W2CDX9	Uncharacterized protein.	Forkhead box O3.	0.413
A0A4W2DS38	PIK3CA	A0A4W2DS38	A0A4W2DQB3	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.592
A0A4W2DS38	PIK3CB	A0A4W2DS38	A0A4W2DY00	Uncharacterized protein.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.547
A0A4W2DS38	PIK3CD	A0A4W2DS38	A0A4W2CS93	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.547
A0A4W2DS38	PIK3R1	A0A4W2DS38	A0A4W2C879	Uncharacterized protein.	Phosphoinositide-3-kinase regulatory subunit 1.	0.565
A0A4W2DS38	PIK3R2	A0A4W2DS38	A0A4W2FTF5	Uncharacterized protein.	Uncharacterized protein.	0.532
A0A4W2DS38	PIK3R3	A0A4W2DS38	A0A4W2EXQ2	Uncharacterized protein.	Uncharacterized protein.	0.532
A0A4W2DS38	TP53	A0A4W2DS38	A0A4W2I2P0	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.671
A0A4W2GYG4	BAD	A0A4W2GYG4	A0A4W2C9A8	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BCL2 associated agonist of cell death.	0.805
A0A4W2GYG4	BRAF	A0A4W2GYG4	A0A4W2EPG5	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	B-Raf proto-oncogene, serine/threonine kinase.	0.940
A0A4W2GYG4	CSDE1	A0A4W2GYG4	A0A4W2D4J0	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cold shock domain containing E1.	0.413
A0A4W2GYG4	ERAS	A0A4W2GYG4	A0A4W2DQW2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	ES cell expressed Ras.	0.413
A0A4W2GYG4	GSK3B	A0A4W2GYG4	A0A4W2CXQ6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.842
A0A4W2GYG4	HRAS	A0A4W2GYG4	A0A4W2H9P0	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	HRas proto-oncogene, GTPase.	0.889
A0A4W2GYG4	KRAS	A0A4W2GYG4	A0A4W2DXR9	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	KRAS proto-oncogene, GTPase.	0.896
A0A4W2GYG4	MAP2K2	A0A4W2GYG4	A0A4W2FV68	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.858
A0A4W2GYG4	MAPK1	A0A4W2GYG4	A0A4W2CPM8	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.940

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