STRINGSTRING
PIK3R1 PIK3R1 E2F3 E2F3 CAMK1 CAMK1 RAF1 RAF1 BAK1 BAK1 PDGFB PDGFB SOS2 SOS2 PRKCG PRKCG AKT3 AKT3 CCND1 CCND1 CAMK1D CAMK1D PIK3CB PIK3CB A0A4W2DXS4 A0A4W2DXS4 KRAS KRAS A0A4W2DS38 A0A4W2DS38 CAMK2G CAMK2G ERAS ERAS PIK3CA PIK3CA NRAS NRAS SHC3 SHC3 GADD45B GADD45B PDGFRB PDGFRB POLK POLK MAP2K1 MAP2K1 CSDE1 CSDE1 CALM1 CALM1 MTOR MTOR MDM2 MDM2 PIK3CD PIK3CD MAPK1 MAPK1 SHC4 SHC4 GRB2 GRB2 AKT2 AKT2 A0A4W2CFU1 A0A4W2CFU1 EGFR EGFR CAMK1G CAMK1G PDGFA PDGFA TGFA TGFA SOS1 SOS1 IGF1R IGF1R MAPK3 MAPK3 PRKCB PRKCB IGF1 IGF1 TP53 TP53 RB1 RB1 DDB2 DDB2 CAMK2B CAMK2B HRAS HRAS E2F2 E2F2 E2F1 E2F1 BAX BAX A0A4W2GYG4 A0A4W2GYG4 PTEN PTEN CAMK2A CAMK2A PRKCA PRKCA ARSI ARSI A0A4W2G5Q0 A0A4W2G5Q0 MAP2K2 MAP2K2 PIK3R2 PIK3R2 CDK6 CDK6 AKT1 AKT1 SHC1 SHC1 PDGFRA PDGFRA PLCG2 PLCG2 CAMK4 CAMK4 GADD45A GADD45A CAMK2D CAMK2D PIK3R3 PIK3R3 A0A4W2EUW0 A0A4W2EUW0 CALML4 CALML4 BRAF BRAF PLCG1 PLCG1 CDK4 CDK4 A0A4W2EIV4 A0A4W2EIV4 A0A4W2EHH7 A0A4W2EHH7 CDKN1A CDKN1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
E2F3E2F transcription factor 3. (465 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (369 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (771 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (428 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. (385 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
A0A4W2DXS4RING-type domain-containing protein. (131 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
A0A4W2DS38Uncharacterized protein. (409 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (596 aa)
ERASES cell expressed Ras. (185 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SHC3SHC adaptor protein 3. (587 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
POLKDNA polymerase kappa. (911 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
CSDE1Cold shock domain containing E1. (844 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (365 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
MDM2MDM2 proto-oncogene. (689 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
SHC4SHC adaptor protein 4. (630 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
A0A4W2CFU1Protein kinase domain-containing protein. (79 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (474 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (401 aa)
TGFATransforming growth factor alpha. (228 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
IGF1Insulin like growth factor 1. (188 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
RB1RB transcriptional corepressor 1. (928 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (830 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
E2F2E2F transcription factor 2. (437 aa)
E2F1E2F transcription factor 1. (437 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ARSIArylsulfatase family member I. (574 aa)
A0A4W2G5Q0Protein kinase domain-containing protein. (79 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
PIK3R2Uncharacterized protein. (724 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
SHC1SHC adaptor protein 1. (584 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
CAMK4Protein kinase domain-containing protein. (750 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CAMK2DProtein kinase domain-containing protein. (544 aa)
PIK3R3Uncharacterized protein. (461 aa)
A0A4W2EUW0Uncharacterized protein. (559 aa)
CALML4Calmodulin like 4. (153 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
A0A4W2EIV4EF-hand domain-containing protein; Belongs to the calmodulin family. (87 aa)
A0A4W2EHH7Uncharacterized protein. (91 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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