STRINGSTRING
SPINT1 SPINT1 E2F3 E2F3 A0A4W2BND6 A0A4W2BND6 CTNNB1 CTNNB1 FOXO1 FOXO1 A0A4W2BS34 A0A4W2BS34 RAF1 RAF1 BCL2 BCL2 IKBKB IKBKB PLAU PLAU AR AR EP300 EP300 ATF4 ATF4 MMP12 MMP12 PDGFB PDGFB A0A4W2C5I5 A0A4W2C5I5 PDGFA PDGFA HSP90AA1 HSP90AA1 PIK3R1 PIK3R1 BAD BAD EGFR EGFR FGFR1 FGFR1 MMP3 MMP3 AKT2 AKT2 GRB2 GRB2 FGFR2 FGFR2 SRD5A2 SRD5A2 CREB3L1 CREB3L1 MAPK1 MAPK1 PIK3CD PIK3CD MDM2 MDM2 MTOR MTOR GSK3B GSK3B A0A4W2CZ95 A0A4W2CZ95 ETV5 ETV5 ZEB1 ZEB1 CASP9 CASP9 CSDE1 CSDE1 MAP2K1 MAP2K1 NKX3-1 NKX3-1 PDGFRB PDGFRB ERG ERG CREBBP CREBBP PDPK1 PDPK1 CREB3L3 CREB3L3 HSP90B1 HSP90B1 NRAS NRAS PIK3CA PIK3CA ERAS ERAS A0A4W2DS38 A0A4W2DS38 PLAT PLAT CREB3L4 CREB3L4 KRAS KRAS A0A4W2DXS4 A0A4W2DXS4 PIK3CB PIK3CB ERBB2 ERBB2 NKX2-3 NKX2-3 LEF1 LEF1 PDGFD PDGFD CREB1 CREB1 CREB3 CREB3 LOC113886404 LOC113886404 CCND1 CCND1 CCNE1 CCNE1 AKT3 AKT3 PDGFC PDGFC SOS2 SOS2 CDKN1A CDKN1A IL1R2 IL1R2 A0A4W2EHH7 A0A4W2EHH7 CCNE2 CCNE2 CREB3L2 CREB3L2 BRAF BRAF PIK3R3 PIK3R3 INSRR INSRR TMPRSS2 TMPRSS2 PDGFRA PDGFRA TCF7 TCF7 CHUK CHUK AKT1 AKT1 PIK3R2 PIK3R2 MAP2K2 MAP2K2 CREB5 CREB5 RELA RELA TCF7L2 TCF7L2 A0A4W2G4L9 A0A4W2G4L9 MMP9 MMP9 PTEN PTEN A0A4W2GYG4 A0A4W2GYG4 E2F1 E2F1 E2F2 E2F2 HRAS HRAS CDKN1B CDKN1B TCF7L1 TCF7L1 CDK2 CDK2 RB1 RB1 TP53 TP53 IGF1 IGF1 NFKB1 NFKB1 MAPK3 MAPK3 IGF1R IGF1R SOS1 SOS1 NFKBIA NFKBIA TGFA TGFA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPINT1Serine peptidase inhibitor, Kunitz type 1. (513 aa)
E2F3E2F transcription factor 3. (465 aa)
A0A4W2BND6IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
CTNNB1Catenin beta 1. (774 aa)
FOXO1Forkhead box O1. (604 aa)
A0A4W2BS34Uncharacterized protein. (147 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
PLAUPlasminogen activator, urokinase. (433 aa)
ARAndrogen receptor. (889 aa)
EP300E1A binding protein p300. (2411 aa)
ATF4Activating transcription factor 4. (348 aa)
MMP12Matrix metallopeptidase 12. (471 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
A0A4W2C5I5Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (104 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (401 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (774 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BADBCL2 associated agonist of cell death. (168 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
FGFR1Fibroblast growth factor receptor. (856 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (254 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (560 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
MDM2MDM2 proto-oncogene. (689 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
A0A4W2CZ95Uncharacterized protein. (506 aa)
ETV5ETS variant 5. (524 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1177 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
CSDE1Cold shock domain containing E1. (844 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
NKX3-1NK3 homeobox 1. (239 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
ERGETS transcription factor ERG. (486 aa)
CREBBPCREB binding protein. (2435 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (747 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (456 aa)
HSP90B1Heat shock protein 90 beta family member 1. (808 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ERASES cell expressed Ras. (185 aa)
A0A4W2DS38Uncharacterized protein. (409 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (393 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
A0A4W2DXS4RING-type domain-containing protein. (131 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ERBB2Erb-b2 receptor tyrosine kinase 2. (1710 aa)
NKX2-3NK2 homeobox 3. (367 aa)
LEF1Lymphoid enhancer binding factor 1. (430 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (558 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CREB3cAMP responsive element binding protein 3. (365 aa)
LOC113886404GST C-terminal domain-containing protein. (274 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (428 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (397 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
IL1R2Interleukin 1 receptor type 2. (400 aa)
A0A4W2EHH7Uncharacterized protein. (91 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (568 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
PIK3R3Uncharacterized protein. (461 aa)
INSRRTyrosine-protein kinase receptor. (1382 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (490 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
TCF7Transcription factor 7. (473 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
PIK3R2Uncharacterized protein. (724 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
CREB5cAMP responsive element binding protein 5. (538 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
TCF7L2Transcription factor 7 like 2. (652 aa)
A0A4W2G4L9Uncharacterized protein. (148 aa)
MMP9Matrix metallopeptidase 9. (712 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
E2F1E2F transcription factor 1. (437 aa)
E2F2E2F transcription factor 2. (437 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
TCF7L1Transcription factor 7 like 1. (588 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
RB1RB transcriptional corepressor 1. (928 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
IGF1Insulin like growth factor 1. (188 aa)
NFKB1Nuclear factor kappa B subunit 1. (974 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
TGFATransforming growth factor alpha. (228 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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