STRINGSTRING
FZD10 FZD10 CTNNB1 CTNNB1 BAK1 BAK1 SUFU SUFU HHIP HHIP WNT5B WNT5B WNT7A WNT7A APC APC KIF7 KIF7 DVL2 DVL2 WNT3 WNT3 WNT11 WNT11 FZD7 FZD7 AXIN2 AXIN2 DVL1 DVL1 WNT6 WNT6 GLI1 GLI1 GLI3 GLI3 WNT10B WNT10B GSK3B GSK3B FZD5 FZD5 PTCH1 PTCH1 FZD6 FZD6 WNT4 WNT4 WNT9A WNT9A POLK POLK PTCH2 PTCH2 GLI2 GLI2 AXIN1 AXIN1 GADD45B GADD45B WNT7B WNT7B LEF1 LEF1 CDKN1A CDKN1A WNT8B WNT8B BMP4 BMP4 FZD3 FZD3 DVL3 DVL3 SHH SHH KIF27 KIF27 APC2 APC2 GADD45A GADD45A WNT5A WNT5A WNT2 WNT2 TCF7 TCF7 FZD1 FZD1 BMP2 BMP2 TCF7L2 TCF7L2 WNT16 WNT16 WNT10A WNT10A SMO SMO FZD8 FZD8 FZD2 FZD2 BAX BAX TCF7L1 TCF7L1 WNT3A WNT3A WNT8A WNT8A FZD4 FZD4 DDB2 DDB2 WNT2B WNT2B TP53 TP53 WNT1 WNT1 WNT9B WNT9B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
CTNNB1Catenin beta 1. (774 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
HHIPHedgehog interacting protein. (701 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
APCAPC regulator of WNT signaling pathway. (2912 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1368 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
AXIN2Axin 2. (836 aa)
DVL1Dishevelled segment polarity protein 1. (708 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
GLI1GLI family zinc finger 1. (1109 aa)
GLI3GLI family zinc finger 3. (1587 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (433 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
PTCH1Patched 1. (1453 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (585 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
POLKDNA polymerase kappa. (911 aa)
PTCH2Patched 2. (1207 aa)
GLI2GLI family zinc finger 2. (1573 aa)
AXIN1Axin 1. (909 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (472 aa)
LEF1Lymphoid enhancer binding factor 1. (430 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
KIF27Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1405 aa)
APC2APC regulator of WNT signaling pathway 2. (2264 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
TCF7Transcription factor 7. (473 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (645 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
TCF7L2Transcription factor 7 like 2. (652 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (661 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
TCF7L1Transcription factor 7 like 1. (588 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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