78 items (Bos indicus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CDH1	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	MDM2	MDM2 proto-oncogene. (689 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
	MAPK1	Mitogen-activated protein kinase. (634 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	AKT2	AKT serine/threonine kinase 2. (603 aa)
	A0A4W2CFU1	Protein kinase domain-containing protein. (79 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	FGFR1	Fibroblast growth factor receptor. (856 aa)
	EGFR	Receptor protein-tyrosine kinase. (1209 aa)
	BAD	BCL2 associated agonist of cell death. (168 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	PDGFA	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (401 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	MITF	Melanocyte inducing transcription factor. (526 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
	A0A4W2BS34	Uncharacterized protein. (147 aa)
	E2F3	E2F transcription factor 3. (465 aa)
	E2F2	E2F transcription factor 2. (437 aa)
	E2F1	E2F transcription factor 1. (437 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	A0A4W2GYG4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
	A0A4W2G5Q0	Protein kinase domain-containing protein. (79 aa)
	A0A4W2G4L9	Uncharacterized protein. (148 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
	PIK3R2	Uncharacterized protein. (724 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	AKT1	Non-specific serine/threonine protein kinase. (747 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (165 aa)
	PIK3R3	Uncharacterized protein. (461 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (805 aa)
	CDK4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
	A0A4W2EHH7	Uncharacterized protein. (91 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (161 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1384 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (397 aa)
	AKT3	AKT serine/threonine kinase 3. (564 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (428 aa)
	PDGFD	Platelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (558 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	A0A4W2DXS4	RING-type domain-containing protein. (131 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	A0A4W2DS38	Uncharacterized protein. (409 aa)
	ERAS	ES cell expressed Ras. (185 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (160 aa)
	HGF	Hepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	POLK	DNA polymerase kappa. (911 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
	GALK2	Galactokinase 2. (458 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
	MAP2K1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
	CSDE1	Cold shock domain containing E1. (844 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1367 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
	IGF1	Insulin like growth factor 1. (188 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
	RB1	RB transcriptional corepressor 1. (928 aa)
	DDB2	Damage specific DNA binding protein 2. (426 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2CFU1	A0A4W2DXS4	A0A4W2CFU1	A0A4W2DXS4	Protein kinase domain-containing protein.	RING-type domain-containing protein.	0.458
A0A4W2CFU1	A0A4W2EHH7	A0A4W2CFU1	A0A4W2EHH7	Protein kinase domain-containing protein.	Uncharacterized protein.	0.417
A0A4W2CFU1	CCND1	A0A4W2CFU1	A0A4W2EBF2	Protein kinase domain-containing protein.	Cyclin D1; Belongs to the cyclin family.	0.980
A0A4W2CFU1	CDH1	A0A4W2CFU1	A0A4W2CVC4	Protein kinase domain-containing protein.	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins.	0.403
A0A4W2CFU1	CDK6	A0A4W2CFU1	A0A4W2FPR8	Protein kinase domain-containing protein.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.908
A0A4W2CFU1	CDKN1A	A0A4W2CFU1	A0A4W2EED6	Protein kinase domain-containing protein.	Cyclin dependent kinase inhibitor 1A.	0.966
A0A4W2CFU1	E2F1	A0A4W2CFU1	A0A4W2H853	Protein kinase domain-containing protein.	E2F transcription factor 1.	0.677
A0A4W2CFU1	E2F2	A0A4W2CFU1	A0A4W2H8U2	Protein kinase domain-containing protein.	E2F transcription factor 2.	0.544
A0A4W2CFU1	E2F3	A0A4W2CFU1	A0A4W2BMQ5	Protein kinase domain-containing protein.	E2F transcription factor 3.	0.552
A0A4W2CFU1	GADD45A	A0A4W2CFU1	A0A4W2F2W6	Protein kinase domain-containing protein.	Growth arrest and DNA damage inducible alpha.	0.454
A0A4W2CFU1	KRAS	A0A4W2CFU1	A0A4W2DXR9	Protein kinase domain-containing protein.	KRAS proto-oncogene, GTPase.	0.439
A0A4W2CFU1	MDM2	A0A4W2CFU1	A0A4W2CSU9	Protein kinase domain-containing protein.	MDM2 proto-oncogene.	0.513
A0A4W2CFU1	PTEN	A0A4W2CFU1	A0A4W2GML2	Protein kinase domain-containing protein.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.477
A0A4W2CFU1	RB1	A0A4W2CFU1	A0A4W2I157	Protein kinase domain-containing protein.	RB transcriptional corepressor 1.	0.948
A0A4W2CFU1	TP53	A0A4W2CFU1	A0A4W2I2P0	Protein kinase domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.661
A0A4W2DS38	AKT1	A0A4W2DS38	A0A4W2FNQ0	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.580
A0A4W2DS38	AKT2	A0A4W2DS38	A0A4W2CI15	Uncharacterized protein.	AKT serine/threonine kinase 2.	0.580
A0A4W2DS38	AKT3	A0A4W2DS38	A0A4W2EBH0	Uncharacterized protein.	AKT serine/threonine kinase 3.	0.580
A0A4W2DS38	MET	A0A4W2DS38	A0A4W2EDJ9	Uncharacterized protein.	MET proto-oncogene, receptor tyrosine kinase.	0.551
A0A4W2DS38	PIK3CA	A0A4W2DS38	A0A4W2DQB3	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.592

page 1 of 88

Server load: low (20%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About