46 items (Bos indicus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A4W2GYG4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
	MMP2	Matrix metallopeptidase 2. (661 aa)
	A0A4W2CFU1	Protein kinase domain-containing protein. (79 aa)
	MAPK1	Mitogen-activated protein kinase. (634 aa)
	MDM2	MDM2 proto-oncogene. (689 aa)
	CDH1	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
	FGFR3	Fibroblast growth factor receptor. (804 aa)
	RPS6KA5	Non-specific serine/threonine protein kinase. (945 aa)
	CSDE1	Cold shock domain containing E1. (844 aa)
	MAP2K1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
	A0A4W2D8G7	Uncharacterized protein. (65 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	DAPK1	Death associated protein kinase 1. (1440 aa)
	ERAS	ES cell expressed Ras. (185 aa)
	A0A4W2DUF4	ZnMc domain-containing protein. (472 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	A0A4W2DXS4	RING-type domain-containing protein. (131 aa)
	ERBB2	Erb-b2 receptor tyrosine kinase 2. (1710 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (394 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (428 aa)
	DAPK2	Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (161 aa)
	A0A4W2EHH7	Uncharacterized protein. (91 aa)
	THBS1	Thrombospondin 1. (1170 aa)
	CDK4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (805 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	SRC	Tyrosine-protein kinase. (559 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
	A0A4W2G5Q0	Protein kinase domain-containing protein. (79 aa)
	MMP9	Matrix metallopeptidase 9. (712 aa)
	E2F1	E2F transcription factor 1. (437 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
	RB1	RB transcriptional corepressor 1. (928 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	E2F2	E2F transcription factor 2. (437 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
	E2F3	E2F transcription factor 3. (465 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
	RASSF1	Ras association domain family member 1. (340 aa)
	MMP20	Matrix metallopeptidase 20. (483 aa)
	UPK3A	Reverse transcriptase domain-containing protein. (467 aa)
	A0A4W2C285	ZnMc domain-containing protein. (469 aa)
	EGFR	Receptor protein-tyrosine kinase. (1209 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2C285	MMP2	A0A4W2C285	A0A4W2CB37	ZnMc domain-containing protein.	Matrix metallopeptidase 2.	0.837
A0A4W2C285	MMP20	A0A4W2C285	A0A4W2BYX9	ZnMc domain-containing protein.	Matrix metallopeptidase 20.	0.649
A0A4W2C285	MMP9	A0A4W2C285	A0A4W2G937	ZnMc domain-containing protein.	Matrix metallopeptidase 9.	0.877
A0A4W2CFU1	A0A4W2DXS4	A0A4W2CFU1	A0A4W2DXS4	Protein kinase domain-containing protein.	RING-type domain-containing protein.	0.458
A0A4W2CFU1	A0A4W2EHH7	A0A4W2CFU1	A0A4W2EHH7	Protein kinase domain-containing protein.	Uncharacterized protein.	0.417
A0A4W2CFU1	CCND1	A0A4W2CFU1	A0A4W2EBF2	Protein kinase domain-containing protein.	Cyclin D1; Belongs to the cyclin family.	0.980
A0A4W2CFU1	CDH1	A0A4W2CFU1	A0A4W2CVC4	Protein kinase domain-containing protein.	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins.	0.403
A0A4W2CFU1	CDKN1A	A0A4W2CFU1	A0A4W2EED6	Protein kinase domain-containing protein.	Cyclin dependent kinase inhibitor 1A.	0.966
A0A4W2CFU1	E2F1	A0A4W2CFU1	A0A4W2H853	Protein kinase domain-containing protein.	E2F transcription factor 1.	0.677
A0A4W2CFU1	E2F2	A0A4W2CFU1	A0A4W2H8U2	Protein kinase domain-containing protein.	E2F transcription factor 2.	0.544
A0A4W2CFU1	E2F3	A0A4W2CFU1	A0A4W2BMQ5	Protein kinase domain-containing protein.	E2F transcription factor 3.	0.552
A0A4W2CFU1	KRAS	A0A4W2CFU1	A0A4W2DXR9	Protein kinase domain-containing protein.	KRAS proto-oncogene, GTPase.	0.439
A0A4W2CFU1	MDM2	A0A4W2CFU1	A0A4W2CSU9	Protein kinase domain-containing protein.	MDM2 proto-oncogene.	0.513
A0A4W2CFU1	RB1	A0A4W2CFU1	A0A4W2I157	Protein kinase domain-containing protein.	RB transcriptional corepressor 1.	0.948
A0A4W2CFU1	TP53	A0A4W2CFU1	A0A4W2I2P0	Protein kinase domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.661
A0A4W2D8G7	EGFR	A0A4W2D8G7	A0A4W2CA87	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.974
A0A4W2D8G7	ERBB2	A0A4W2D8G7	A0A4W2DYP3	Uncharacterized protein.	Erb-b2 receptor tyrosine kinase 2.	0.686
A0A4W2D8G7	KRAS	A0A4W2D8G7	A0A4W2DXR9	Uncharacterized protein.	KRAS proto-oncogene, GTPase.	0.440
A0A4W2D8G7	MMP2	A0A4W2D8G7	A0A4W2CB37	Uncharacterized protein.	Matrix metallopeptidase 2.	0.815
A0A4W2D8G7	MMP20	A0A4W2D8G7	A0A4W2BYX9	Uncharacterized protein.	Matrix metallopeptidase 20.	0.550

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