STRINGSTRING
FGF17 FGF17 E2F3 E2F3 BRCA2 BRCA2 CTNNB1 CTNNB1 RPS6KB1 RPS6KB1 RAF1 RAF1 TNFSF11 TNFSF11 RPS6KB2 RPS6KB2 BAK1 BAK1 A0A4W2C276 A0A4W2C276 NFKB2 NFKB2 WNT5B WNT5B JAG2 JAG2 FGF6 FGF6 PIK3R1 PIK3R1 WNT7A WNT7A APC APC EGFR EGFR DVL2 DVL2 HEY2 HEY2 NCOA7 NCOA7 FGFR1 FGFR1 WNT3 WNT3 FGF20 FGF20 WNT11 WNT11 A0A4W2CFU1 A0A4W2CFU1 FZD7 FZD7 DLL3 DLL3 AKT2 AKT2 AXIN2 AXIN2 GRB2 GRB2 DVL1 DVL1 HES5 HES5 FGF21 FGF21 SHC4 SHC4 MAPK1 MAPK1 WNT6 WNT6 PIK3CD PIK3CD FGF18 FGF18 MTOR MTOR DLL4 DLL4 WNT10B WNT10B GSK3B GSK3B DLL1 DLL1 CCDC170 CCDC170 FZD5 FZD5 CSDE1 CSDE1 MAP2K1 MAP2K1 NCOA3 NCOA3 FZD6 FZD6 FGF22 FGF22 GALK2 GALK2 FLT4 FLT4 HEYL HEYL A0A4W2D9N9 A0A4W2D9N9 WNT4 WNT4 WNT9A WNT9A LRP6 LRP6 POLK POLK FGF1 FGF1 KIT KIT NOTCH3 NOTCH3 CSNK1A1 CSNK1A1 AXIN1 AXIN1 HES1 HES1 FOS FOS GADD45B GADD45B SHC3 SHC3 NRAS NRAS PIK3CA PIK3CA ERAS ERAS LRP5 LRP5 A0A4W2DS38 A0A4W2DS38 WNT7B WNT7B NOTCH1 NOTCH1 KRAS KRAS PIK3CB PIK3CB FGF23 FGF23 ERBB2 ERBB2 NOTCH4 NOTCH4 PGR PGR LEF1 LEF1 A0A4W2E1S4 A0A4W2E1S4 FZD10 FZD10 CCND1 CCND1 FGF3 FGF3 AKT3 AKT3 BRCA1 BRCA1 FGF2 FGF2 SOS2 SOS2 CDKN1A CDKN1A WNT8B WNT8B FRAT2 FRAT2 CDK4 CDK4 NCOA1 NCOA1 FZD3 FZD3 BRAF BRAF SP1 SP1 DVL3 DVL3 NOTCH2 NOTCH2 A0A4W2EUW0 A0A4W2EUW0 APC2 APC2 PIK3R3 PIK3R3 GADD45A GADD45A WNT5A WNT5A FGF9 FGF9 WNT2 WNT2 TCF7 TCF7 SHC1 SHC1 JAG1 JAG1 FZD1 FZD1 AKT1 AKT1 FGF8 FGF8 CDK6 CDK6 PIK3R2 PIK3R2 MAP2K2 MAP2K2 FGF7 FGF7 TCF7L2 TCF7L2 A0A4W2G5Q0 A0A4W2G5Q0 ESR1 ESR1 FGF5 FGF5 WNT16 WNT16 WNT10A WNT10A FGF4 FGF4 PTEN PTEN FZD8 FZD8 FZD2 FZD2 A0A4W2GYG4 A0A4W2GYG4 BAX BAX E2F1 E2F1 MYC MYC E2F2 E2F2 HRAS HRAS LOC113886677 LOC113886677 ESR2 ESR2 TCF7L1 TCF7L1 FGF10 FGF10 WNT3A WNT3A WNT8A WNT8A HEY1 HEY1 FZD4 FZD4 DDB2 DDB2 WNT2B WNT2B RB1 RB1 TP53 TP53 WNT1 WNT1 IGF1 IGF1 JUN JUN WNT9B WNT9B MAPK3 MAPK3 FGF19 FGF19 IGF1R IGF1R SOS1 SOS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
E2F3E2F transcription factor 3. (465 aa)
BRCA2BRCA2 DNA repair associated. (3420 aa)
CTNNB1Catenin beta 1. (774 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (316 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
A0A4W2C276Uncharacterized protein. (275 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1239 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
APCAPC regulator of WNT signaling pathway. (2912 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
NCOA7Nuclear receptor coactivator 7. (952 aa)
FGFR1Fibroblast growth factor receptor. (856 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
A0A4W2CFU1Protein kinase domain-containing protein. (79 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
DLL3Delta like canonical Notch ligand 3. (645 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
AXIN2Axin 2. (836 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
DVL1Dishevelled segment polarity protein 1. (708 aa)
HES5Hes family bHLH transcription factor 5. (227 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
SHC4SHC adaptor protein 4. (630 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (433 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (722 aa)
CCDC170Coiled-coil domain containing 170. (714 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
CSDE1Cold shock domain containing E1. (844 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
NCOA3Nuclear receptor coactivator. (1411 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
GALK2Galactokinase 2. (458 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1365 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (329 aa)
A0A4W2D9N9Uncharacterized protein. (590 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (585 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1644 aa)
POLKDNA polymerase kappa. (911 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
NOTCH3Notch receptor 3. (2313 aa)
CSNK1A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (394 aa)
AXIN1Axin 1. (909 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
SHC3SHC adaptor protein 3. (587 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ERASES cell expressed Ras. (185 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1629 aa)
A0A4W2DS38Uncharacterized protein. (409 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (472 aa)
NOTCH1Notch receptor 1. (2533 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
ERBB2Erb-b2 receptor tyrosine kinase 2. (1710 aa)
NOTCH4Notch receptor 4. (1992 aa)
PGRProgesterone receptor. (921 aa)
LEF1Lymphoid enhancer binding factor 1. (430 aa)
A0A4W2E1S4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (335 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (428 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
BRCA1BRCA1 DNA repair associated. (1941 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FRAT2FRAT regulator of WNT signaling pathway 2. (229 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
NCOA1Nuclear receptor coactivator. (1440 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
SP1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1209 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
NOTCH2Notch receptor 2. (2471 aa)
A0A4W2EUW0Uncharacterized protein. (559 aa)
APC2APC regulator of WNT signaling pathway 2. (2264 aa)
PIK3R3Uncharacterized protein. (461 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
TCF7Transcription factor 7. (473 aa)
SHC1SHC adaptor protein 1. (584 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (645 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PIK3R2Uncharacterized protein. (724 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
TCF7L2Transcription factor 7 like 2. (652 aa)
A0A4W2G5Q0Protein kinase domain-containing protein. (79 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (661 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
E2F1E2F transcription factor 1. (437 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
E2F2E2F transcription factor 2. (437 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LOC113886677Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (336 aa)
ESR2Estrogen receptor 2. (527 aa)
TCF7L1Transcription factor 7 like 1. (588 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (308 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
RB1RB transcriptional corepressor 1. (928 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
IGF1Insulin like growth factor 1. (188 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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