STRINGSTRING
RPS6KB1 RPS6KB1 CTNNB1 CTNNB1 E2F3 E2F3 FZD7 FZD7 DVL1 DVL1 FGF21 FGF21 TGFBR1 TGFBR1 SHC4 SHC4 MAPK1 MAPK1 WNT6 WNT6 PIK3CD PIK3CD FGF18 FGF18 MTOR MTOR CDH1 CDH1 WNT10B WNT10B GSK3B GSK3B FZD5 FZD5 CSDE1 CSDE1 MAP2K1 MAP2K1 FZD6 FZD6 FGF22 FGF22 GALK2 GALK2 FGF17 FGF17 WNT4 WNT4 WNT9A WNT9A LRP6 LRP6 POLK POLK FGF1 FGF1 CSNK1A1 CSNK1A1 A0A4W2DG11 A0A4W2DG11 CDKN2A CDKN2A HGF HGF AXIN1 AXIN1 GADD45B GADD45B RXRG RXRG SHC3 SHC3 NRAS NRAS PIK3CA PIK3CA SMAD4 SMAD4 ERAS ERAS LRP5 LRP5 WNT7B WNT7B KRAS KRAS PIK3CB PIK3CB FGF23 FGF23 ERBB2 ERBB2 LEF1 LEF1 A0A4W2E1S4 A0A4W2E1S4 FZD10 FZD10 TGFBR2 TGFBR2 CCND1 CCND1 CCNE1 CCNE1 FGF3 FGF3 AKT3 AKT3 FGF2 FGF2 SOS2 SOS2 MET MET CDKN1A CDKN1A WNT8B WNT8B FRAT2 FRAT2 CCNE2 CCNE2 FZD3 FZD3 BRAF BRAF TGFB3 TGFB3 SMAD3 SMAD3 DVL3 DVL3 REG4 REG4 SHH SHH A0A4W2EUW0 A0A4W2EUW0 APC2 APC2 PIK3R3 PIK3R3 A0A4W2EZ96 A0A4W2EZ96 GADD45A GADD45A WNT5A WNT5A FGF9 FGF9 WNT2 WNT2 TCF7 TCF7 CDX2 CDX2 SHC1 SHC1 LOC113900834 LOC113900834 FZD1 FZD1 AKT1 AKT1 FGF8 FGF8 CTNNA1 CTNNA1 PIK3R2 PIK3R2 MAP2K2 MAP2K2 FGF7 FGF7 TCF7L2 TCF7L2 CTNNA3 CTNNA3 FGF5 FGF5 WNT16 WNT16 WNT10A WNT10A FGF4 FGF4 FZD8 FZD8 CDKN2B CDKN2B FZD2 FZD2 A0A4W2GYG4 A0A4W2GYG4 RARB RARB BAX BAX E2F1 E2F1 MYC MYC E2F2 E2F2 HRAS HRAS LOC113886677 LOC113886677 TGFB2 TGFB2 GAB1 GAB1 LOC113901336 LOC113901336 CDKN1B CDKN1B TCF7L1 TCF7L1 FGF10 FGF10 WNT3A WNT3A WNT8A WNT8A RXRB RXRB CDK2 CDK2 FZD4 FZD4 DDB2 DDB2 WNT2B WNT2B RB1 RB1 TP53 TP53 WNT1 WNT1 WNT9B WNT9B MAPK3 MAPK3 FGF19 FGF19 SOS1 SOS1 JUP JUP FGFR2 FGFR2 GRB2 GRB2 AXIN2 AXIN2 TGFB1 TGFB1 AKT2 AKT2 TERT TERT WNT11 WNT11 FGF20 FGF20 WNT3 WNT3 CTNNA2 CTNNA2 DVL2 DVL2 EGFR EGFR CDH17 CDH17 APC APC WNT7A WNT7A PIK3R1 PIK3R1 FGF6 FGF6 WNT5B WNT5B A0A4W2C276 A0A4W2C276 BAK1 BAK1 BCL2 BCL2 RPS6KB2 RPS6KB2 SMAD2 SMAD2 MLH1 MLH1 RXRA RXRA RAF1 RAF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CTNNB1Catenin beta 1. (774 aa)
E2F3E2F transcription factor 3. (465 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
DVL1Dishevelled segment polarity protein 1. (708 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
SHC4SHC adaptor protein 4. (630 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (433 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
CSDE1Cold shock domain containing E1. (844 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
GALK2Galactokinase 2. (458 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (585 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1644 aa)
POLKDNA polymerase kappa. (911 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
CSNK1A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (394 aa)
A0A4W2DG11Uncharacterized protein. (1289 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (160 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
AXIN1Axin 1. (909 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
RXRGRetinoid X receptor gamma. (463 aa)
SHC3SHC adaptor protein 3. (587 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
ERASES cell expressed Ras. (185 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1629 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (472 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
ERBB2Erb-b2 receptor tyrosine kinase 2. (1710 aa)
LEF1Lymphoid enhancer binding factor 1. (430 aa)
A0A4W2E1S4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (335 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (428 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1384 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FRAT2FRAT regulator of WNT signaling pathway 2. (229 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
REG4Regenerating family member 4. (158 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
A0A4W2EUW0Uncharacterized protein. (559 aa)
APC2APC regulator of WNT signaling pathway 2. (2264 aa)
PIK3R3Uncharacterized protein. (461 aa)
A0A4W2EZ96Uncharacterized protein. (1258 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
TCF7Transcription factor 7. (473 aa)
CDX2Caudal type homeobox 2. (306 aa)
SHC1SHC adaptor protein 1. (584 aa)
LOC113900834C-type lectin domain-containing protein. (204 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (645 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
CTNNA1Catenin alpha 1. (919 aa)
PIK3R2Uncharacterized protein. (724 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
TCF7L2Transcription factor 7 like 2. (652 aa)
CTNNA3Catenin alpha 3. (895 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (661 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
RARBRetinoic acid receptor beta. (456 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
E2F1E2F transcription factor 1. (437 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
E2F2E2F transcription factor 2. (437 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LOC113886677Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (336 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
LOC113901336C-type lectin domain-containing protein. (175 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
TCF7L1Transcription factor 7 like 1. (588 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
RXRBRetinoid X receptor beta. (536 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
RB1RB transcriptional corepressor 1. (928 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
JUPJunction plakoglobin. (745 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
AXIN2Axin 2. (836 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1125 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
CTNNA2Catenin alpha 2. (953 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
CDH17Cadherin 17. (832 aa)
APCAPC regulator of WNT signaling pathway. (2912 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
A0A4W2C276Uncharacterized protein. (275 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
SMAD2Mothers against decapentaplegic homolog. (626 aa)
MLH1MutL homolog 1. (758 aa)
RXRARetinoid X receptor alpha. (657 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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