STRINGSTRING
PARP8 PARP8 A0A4W2E974 A0A4W2E974 MET MET PDHB PDHB RAF1 RAF1 HK1 HK1 RET RET SLC7A5 SLC7A5 SCO1 SCO1 SIRT3 SIRT3 PIK3R1 PIK3R1 SLC16A3 SLC16A3 EGFR EGFR FGFR1 FGFR1 AKT2 AKT2 FGFR2 FGFR2 HK2 HK2 MAPK1 MAPK1 PIK3CD PIK3CD MTOR MTOR A0A4W2CVX0 A0A4W2CVX0 PFKM PFKM FGFR3 FGFR3 CSDE1 CSDE1 MAP2K1 MAP2K1 A0A4W2D9D4 A0A4W2D9D4 TNIK TNIK PDK1 PDK1 KIT KIT PDGFRB PDGFRB SIRT6 SIRT6 NRAS NRAS AKT3 AKT3 PGAM2 PGAM2 FLT3 FLT3 PIK3CA PIK3CA PGAM1 PGAM1 MAPK3 MAPK3 TIGAR TIGAR TP53 TP53 GLS2 GLS2 NTRK1 NTRK1 PFKP PFKP HIF1A HIF1A IDH1 IDH1 HRAS HRAS MYC MYC A0A4W2GYG4 A0A4W2GYG4 LDHA LDHA LDHC LDHC PTEN PTEN NTRK3 NTRK3 GCK GCK MAP2K2 MAP2K2 PIK3R2 PIK3R2 AKT1 AKT1 PDGFRA PDGFRA GLS GLS PFKL PFKL PDHA2 PDHA2 LDHB LDHB PIK3R3 PIK3R3 SLC2A1 SLC2A1 SLC2A2 SLC2A2 HK3 HK3 PKM PKM SLC1A5 SLC1A5 ERAS ERAS A0A4W2DS38 A0A4W2DS38 KRAS KRAS PIK3CB PIK3CB IDH2 IDH2 ERBB2 ERBB2 SCO2 SCO2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PARP8Poly [ADP-ribose] polymerase. (923 aa)
A0A4W2E974Ldh_1_N domain-containing protein. (92 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1384 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (361 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
HK1Hexokinase 1. (920 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
SLC7A5Solute carrier family 7 member 5. (507 aa)
SCO1SCO cytochrome c oxidase assembly protein 1. (305 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (395 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SLC16A3Solute carrier family 16 member 3. (461 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
FGFR1Fibroblast growth factor receptor. (856 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
HK2Hexokinase 2. (917 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
A0A4W2CVX0Uncharacterized protein. (196 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (850 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
CSDE1Cold shock domain containing E1. (844 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
A0A4W2D9D4L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
TNIKTRAF2 and NCK interacting kinase. (1389 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
SIRT6Sirtuin 6. (391 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
GLS2Glutaminase 2. (602 aa)
NTRK1Tyrosine-protein kinase receptor. (821 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (960 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (331 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
GCKPhosphotransferase. (466 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
PIK3R2Uncharacterized protein. (724 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
GLSGlutaminase. (675 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (325 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
PIK3R3Uncharacterized protein. (461 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (530 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (532 aa)
HK3Hexokinase 3. (924 aa)
PKMMultifunctional fusion protein; Belongs to the pyruvate kinase family. (926 aa)
SLC1A5Amino acid transporter. (539 aa)
ERASES cell expressed Ras. (185 aa)
A0A4W2DS38Uncharacterized protein. (409 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (477 aa)
ERBB2Erb-b2 receptor tyrosine kinase 2. (1710 aa)
SCO2SCO cytochrome c oxidase assembly protein 2. (266 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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