STRINGSTRING
PRKCG PRKCG SOS2 SOS2 PLA2G4D PLA2G4D SLC44A4 SLC44A4 A0A4W2EHI1 A0A4W2EHI1 PLA2G4F PLA2G4F DGKG DGKG SLC22A1 SLC22A1 PLCG1 PLCG1 SP1 SP1 A0A4W2EQN1 A0A4W2EQN1 TSC2 TSC2 WASF3 WASF3 DGKH DGKH RPS6KB1 RPS6KB1 RAF1 RAF1 RPS6KB2 RPS6KB2 PDGFB PDGFB PDGFA PDGFA RAC3 RAC3 PIK3R1 PIK3R1 RAC1 RAC1 EGFR EGFR PLD2 PLD2 PLPP1 PLPP1 A0A4W2CCQ3 A0A4W2CCQ3 LYPLA1 LYPLA1 AKT2 AKT2 GRB2 GRB2 MAPK1 MAPK1 PIK3CD PIK3CD MTOR MTOR DGKI DGKI PLA2G4E PLA2G4E A0A4W2CZ07 A0A4W2CZ07 PCYT1A PCYT1A RHEBL1 RHEBL1 SLC22A2 SLC22A2 A0A4W2D456 A0A4W2D456 CSDE1 CSDE1 MAP2K1 MAP2K1 MAPK8 MAPK8 SLC44A1 SLC44A1 DGKB DGKB PDGFRB PDGFRB SLC22A3 SLC22A3 CHPT1 CHPT1 SLC44A5 SLC44A5 PLPP3 PLPP3 PDPK1 PDPK1 RHEB RHEB FOS FOS SLC22A5 SLC22A5 WAS WAS DGKA DGKA NRAS NRAS DGKE DGKE PIK3CA PIK3CA PLD1 PLD1 PIP5K1A PIP5K1A A0A4W2EV68 A0A4W2EV68 A0A4W2EVF4 A0A4W2EVF4 PIK3R3 PIK3R3 RAC2 RAC2 SLC44A2 SLC44A2 MAPK9 MAPK9 SLC44A3 SLC44A3 WASF1 WASF1 PDGFRA PDGFRA WASF2 WASF2 AKT1 AKT1 GPCPD1 GPCPD1 PIK3R2 PIK3R2 MAP2K2 MAP2K2 PIP5K1B PIP5K1B MAPK10 MAPK10 PRKCA PRKCA DGKD DGKD A0A4W2GYG4 A0A4W2GYG4 HRAS HRAS HIF1A HIF1A PIP5K1C PIP5K1C DGKZ DGKZ JUN JUN PRKCB PRKCB MAPK3 MAPK3 SOS1 SOS1 JMJD7 JMJD7 ERAS ERAS TSC1 TSC1 KRAS KRAS CHKB CHKB PIK3CB PIK3CB RALGDS RALGDS A0A4W2E0W0 A0A4W2E0W0 PDGFD PDGFD SLC5A7 SLC5A7 PLA2G4A PLA2G4A EIF4EBP1 EIF4EBP1 AKT3 AKT3 PDGFC PDGFC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (771 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PLA2G4DPhospholipase A2. (808 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (706 aa)
A0A4W2EHI1Uncharacterized protein. (170 aa)
PLA2G4FPhospholipase A2. (845 aa)
DGKGDiacylglycerol kinase. (791 aa)
SLC22A1Solute carrier family 22 member 1. (563 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
SP1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1209 aa)
A0A4W2EQN1Phorbol-ester/DAG-type domain-containing protein. (322 aa)
TSC2TSC complex subunit 2. (1887 aa)
WASF3WASP family member 3. (501 aa)
DGKHDiacylglycerol kinase. (1214 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (401 aa)
RAC3Rac family small GTPase 3. (258 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RAC1Rac family small GTPase 1. (257 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PLD2Phospholipase. (1088 aa)
PLPP1Phospholipid phosphatase 1. (286 aa)
A0A4W2CCQ3Uncharacterized protein. (865 aa)
LYPLA1Uncharacterized protein. (358 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
DGKIDiacylglycerol kinase. (1065 aa)
PLA2G4EPhospholipase A2. (860 aa)
A0A4W2CZ07Phospholipase A2. (821 aa)
PCYT1APhosphate cytidylyltransferase 1, choline, alpha. (381 aa)
RHEBL1RHEB like 1. (195 aa)
SLC22A2Solute carrier family 22 member 2. (549 aa)
A0A4W2D456acidPPc domain-containing protein. (368 aa)
CSDE1Cold shock domain containing E1. (844 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SLC44A1Solute carrier family 44 member 1; Belongs to the CTL (choline transporter-like) family. (653 aa)
DGKBDiacylglycerol kinase. (803 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
SLC22A3Solute carrier family 22 member 3. (625 aa)
CHPT1Choline phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (413 aa)
SLC44A5Solute carrier family 44 member 5; Belongs to the CTL (choline transporter-like) family. (721 aa)
PLPP3acidPPc domain-containing protein. (311 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (747 aa)
RHEBUncharacterized protein. (214 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SLC22A5Solute carrier family 22 member 5. (557 aa)
WASWASP actin nucleation promoting factor. (559 aa)
DGKADiacylglycerol kinase. (734 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
DGKEDiacylglycerol kinase. (564 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLD1Phospholipase. (1126 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
A0A4W2EV68acidPPc domain-containing protein. (458 aa)
A0A4W2EVF4Abhydrolase_2 domain-containing protein. (234 aa)
PIK3R3Uncharacterized protein. (461 aa)
RAC2Rac family small GTPase 2. (209 aa)
SLC44A2Solute carrier family 44 member 2; Belongs to the CTL (choline transporter-like) family. (746 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SLC44A3Solute carrier family 44 member 3; Belongs to the CTL (choline transporter-like) family. (651 aa)
WASF1WASP family member 1. (570 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
WASF2WASP family member 2. (493 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
GPCPD1Glycerophosphocholine phosphodiesterase 1. (672 aa)
PIK3R2Uncharacterized protein. (724 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (519 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
DGKDDiacylglycerol kinase. (1215 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (695 aa)
DGKZDiacylglycerol kinase. (1193 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
JMJD7Jumonji domain containing 7. (316 aa)
ERASES cell expressed Ras. (185 aa)
TSC1TSC complex subunit 1. (1165 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CHKBCholine kinase beta. (452 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
RALGDSUncharacterized protein. (1077 aa)
A0A4W2E0W0Abhydrolase_2 domain-containing protein. (51 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (558 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
PLA2G4APhospholipase A2. (749 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (178 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (397 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.