STRINGSTRING
NRAS NRAS RPS6KB1 RPS6KB1 RAF1 RAF1 LAT LAT CD3E CD3E RPS6KB2 RPS6KB2 PPP3CB PPP3CB IKBKB IKBKB CD3D CD3D MAPK11 MAPK11 TLR2 TLR2 TIRAP TIRAP PIK3R1 PIK3R1 EGFR EGFR MAPK12 MAPK12 AKT2 AKT2 EML4 EML4 NFATC2 NFATC2 CD4 CD4 MAPK1 MAPK1 PTPN6 PTPN6 A0A4W2CR26 A0A4W2CR26 PIK3CD PIK3CD MTOR MTOR IFNGR1 IFNGR1 A0A4W2D056 A0A4W2D056 A0A4W2D095 A0A4W2D095 A0A4W2D0D6 A0A4W2D0D6 A0A4W2D0E0 A0A4W2D0E0 A0A4W2D0G3 A0A4W2D0G3 A0A4W2D0I4 A0A4W2D0I4 A0A4W2D2L8 A0A4W2D2L8 A0A4W2D2R2 A0A4W2D2R2 A0A4W2D2S0 A0A4W2D2S0 A0A4W2D2S8 A0A4W2D2S8 A0A4W2D2T1 A0A4W2D2T1 A0A4W2D2W9 A0A4W2D2W9 TLR4 TLR4 CSDE1 CSDE1 MAP2K1 MAP2K1 A0A4W2D4V5 A0A4W2D4V5 A0A4W2D520 A0A4W2D520 A0A4W2D547 A0A4W2D547 A0A4W2D552 A0A4W2D552 A0A4W2D597 A0A4W2D597 A0A4W2D5F7 A0A4W2D5F7 A0A4W2D5G0 A0A4W2D5G0 A0A4W2D5H8 A0A4W2D5H8 A0A4W2D5P0 A0A4W2D5P0 A0A4W2D704 A0A4W2D704 A0A4W2D709 A0A4W2D709 A0A4W2D724 A0A4W2D724 A0A4W2D760 A0A4W2D760 A0A4W2D781 A0A4W2D781 A0A4W2D7C1 A0A4W2D7C1 A0A4W2DK77 A0A4W2DK77 A0A4W2DK85 A0A4W2DK85 FOS FOS A0A4W2DMB6 A0A4W2DMB6 TRBV24-1 TRBV24-1 A0A4W2DMM0 A0A4W2DMM0 PIK3CA PIK3CA ERAS ERAS PDCD1 PDCD1 A0A4W2DRK4 A0A4W2DRK4 A0A4W2DS38 A0A4W2DS38 PPP3CC PPP3CC MAPK13 MAPK13 LY6G5B LY6G5B KRAS KRAS PIK3CB PIK3CB STAT1 STAT1 PRKCQ PRKCQ MAP2K6 MAP2K6 CD28 CD28 MAP3K3 MAP3K3 A0A4W2E7C9 A0A4W2E7C9 STAT3 STAT3 NFKBIB NFKBIB AKT3 AKT3 CSNK2A1 CSNK2A1 RASGRP1 RASGRP1 MAP2K3 MAP2K3 IFNG IFNG ZAP70 ZAP70 PLCG1 PLCG1 ALK ALK A0A4W2EPY6 A0A4W2EPY6 A0A4W2EQ07 A0A4W2EQ07 A0A4W2EQ96 A0A4W2EQ96 A0A4W2EQA0 A0A4W2EQA0 TICAM1 TICAM1 A0A4W2EQB9 A0A4W2EQB9 A0A4W2EQG3 A0A4W2EQG3 A0A4W2EQH2 A0A4W2EQH2 A0A4W2ERF0 A0A4W2ERF0 A0A4W2ERG5 A0A4W2ERG5 A0A4W2ERJ1 A0A4W2ERJ1 A0A4W2ERJ9 A0A4W2ERJ9 A0A4W2ERN6 A0A4W2ERN6 A0A4W2ERP9 A0A4W2ERP9 A0A4W2ES23 A0A4W2ES23 A0A4W2ES53 A0A4W2ES53 A0A4W2ES87 A0A4W2ES87 PIK3R3 PIK3R3 IFNGR2 IFNGR2 PPP3CA PPP3CA CD247 CD247 A0A4W2FDM7 A0A4W2FDM7 CHUK CHUK AKT1 AKT1 PIK3R2 PIK3R2 MAP2K2 MAP2K2 BATF2 BATF2 RELA RELA CSNK2B CSNK2B LOC113899224 LOC113899224 CD274 CD274 CSNK2A2 CSNK2A2 LOC113899224-2 LOC113899224-2 PTEN PTEN JAK1 JAK1 NFATC3 NFATC3 BATF BATF BATF3 BATF3 PTPN11 PTPN11 A0A4W2GYG4 A0A4W2GYG4 HRAS HRAS HIF1A HIF1A LCK LCK JAK2 JAK2 JUN JUN NFKB1 NFKB1 MYD88 MYD88 A0A4W2I9H2 A0A4W2I9H2 A0A4W2I9W6 A0A4W2I9W6 MAPK3 MAPK3 NFKBIA NFKBIA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRASNRAS proto-oncogene, GTPase. (189 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
LATUncharacterized protein. (295 aa)
CD3ECD3e molecule. (197 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
CD3DCD3d molecule. (167 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (861 aa)
TIRAPTIR domain containing adaptor protein. (327 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
EML4EMAP like 4. (992 aa)
NFATC2Nuclear factor of activated T cells 2. (914 aa)
CD4CD4 molecule. (455 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
A0A4W2CR26TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
IFNGR1Interferon gamma receptor 1. (500 aa)
A0A4W2D056Ig-like domain-containing protein. (153 aa)
A0A4W2D095Ig-like domain-containing protein. (143 aa)
A0A4W2D0D6Ig-like domain-containing protein. (177 aa)
A0A4W2D0E0Ig-like domain-containing protein. (136 aa)
A0A4W2D0G3Ig-like domain-containing protein. (151 aa)
A0A4W2D0I4Ig-like domain-containing protein. (112 aa)
A0A4W2D2L8Ig-like domain-containing protein. (147 aa)
A0A4W2D2R2Ig-like domain-containing protein. (118 aa)
A0A4W2D2S0Ig-like domain-containing protein. (174 aa)
A0A4W2D2S8Ig-like domain-containing protein. (127 aa)
A0A4W2D2T1Ig-like domain-containing protein. (127 aa)
A0A4W2D2W9Ig-like domain-containing protein. (261 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
CSDE1Cold shock domain containing E1. (844 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
A0A4W2D4V5Uncharacterized protein. (607 aa)
A0A4W2D520Ig-like domain-containing protein. (202 aa)
A0A4W2D547Ig-like domain-containing protein. (146 aa)
A0A4W2D552Ig-like domain-containing protein. (153 aa)
A0A4W2D597Ig-like domain-containing protein. (112 aa)
A0A4W2D5F7Ig-like domain-containing protein. (182 aa)
A0A4W2D5G0Ig-like domain-containing protein. (106 aa)
A0A4W2D5H8Ig-like domain-containing protein. (237 aa)
A0A4W2D5P0DUF1968 domain-containing protein. (225 aa)
A0A4W2D704Ig-like domain-containing protein. (150 aa)
A0A4W2D709Ig-like domain-containing protein. (165 aa)
A0A4W2D724Ig-like domain-containing protein. (177 aa)
A0A4W2D760Ig-like domain-containing protein. (128 aa)
A0A4W2D781Ig-like domain-containing protein. (137 aa)
A0A4W2D7C1Ig-like domain-containing protein. (127 aa)
A0A4W2DK77Ig-like domain-containing protein. (193 aa)
A0A4W2DK85Ig-like domain-containing protein. (111 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
A0A4W2DMB6Ig-like domain-containing protein. (172 aa)
TRBV24-1T cell receptor beta variable 24-1. (97 aa)
A0A4W2DMM0IGv domain-containing protein. (177 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ERASES cell expressed Ras. (185 aa)
PDCD1Programmed cell death 1. (289 aa)
A0A4W2DRK4IGv domain-containing protein. (83 aa)
A0A4W2DS38Uncharacterized protein. (409 aa)
PPP3CCSerine/threonine-protein phosphatase. (531 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
LY6G5BLymphocyte antigen 6 family member G5B. (200 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
STAT1Signal transducer and activator of transcription. (821 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (764 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
CD28CD28 molecule. (265 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
A0A4W2E7C9TNF receptor-associated factor. (411 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
NFKBIBNFKB inhibitor beta. (357 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (452 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
ZAP70Tyrosine-protein kinase. (617 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
ALKTyrosine-protein kinase receptor. (1621 aa)
A0A4W2EPY6Ig-like domain-containing protein. (102 aa)
A0A4W2EQ07Ig-like domain-containing protein. (95 aa)
A0A4W2EQ96Ig-like domain-containing protein. (157 aa)
A0A4W2EQA0Ig-like domain-containing protein. (207 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (759 aa)
A0A4W2EQB9Ig-like domain-containing protein. (189 aa)
A0A4W2EQG3Ig-like domain-containing protein. (217 aa)
A0A4W2EQH2Ig-like domain-containing protein. (102 aa)
A0A4W2ERF0Ig-like domain-containing protein. (150 aa)
A0A4W2ERG5Ig-like domain-containing protein. (136 aa)
A0A4W2ERJ1Ig-like domain-containing protein. (174 aa)
A0A4W2ERJ9Ig-like domain-containing protein. (181 aa)
A0A4W2ERN6Ig-like domain-containing protein. (127 aa)
A0A4W2ERP9Ig-like domain-containing protein. (331 aa)
A0A4W2ES23Uncharacterized protein. (128 aa)
A0A4W2ES53Ig-like domain-containing protein. (222 aa)
A0A4W2ES87IGv domain-containing protein. (140 aa)
PIK3R3Uncharacterized protein. (461 aa)
IFNGR2Interferon gamma receptor 2. (376 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CD247CD247 molecule. (166 aa)
A0A4W2FDM7TIR domain-containing protein. (1029 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
PIK3R2Uncharacterized protein. (724 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
BATF2Basic leucine zipper ATF-like transcription factor 2. (275 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa)
LOC113899224Toll like receptor adaptor molecule 2. (232 aa)
CD274CD274 molecule. (289 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (385 aa)
LOC113899224-2GOLD domain-containing protein. (225 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
JAK1Tyrosine-protein kinase. (1110 aa)
NFATC3Nuclear factor of activated T cells 3. (1073 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
BATF3Basic leucine zipper ATF-like transcription factor 3. (122 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
LCKTyrosine-protein kinase. (509 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
NFKB1Nuclear factor kappa B subunit 1. (974 aa)
MYD88MYD88 innate immune signal transduction adaptor. (384 aa)
A0A4W2I9H2Ig-like domain-containing protein. (102 aa)
A0A4W2I9W6Ig-like domain-containing protein. (167 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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