STRINGSTRING
MAP3K7 MAP3K7 PIK3CA PIK3CA NCF1 NCF1 CCL2 CCL2 MAPK13 MAPK13 PLAT PLAT ACVR1 ACVR1 ARHGEF2 ARHGEF2 PIK3CB PIK3CB TNFRSF1A TNFRSF1A ACTB ACTB TXN2 TXN2 VEGFA VEGFA CDH5 CDH5 KEAP1 KEAP1 MAP2K6 MAP2K6 ACTBL2 ACTBL2 NQO1 NQO1 PECAM1 PECAM1 A0A4W2E9P7 A0A4W2E9P7 LOC113886404 LOC113886404 AKT3 AKT3 BMPR2 BMPR2 A0A4W2EEQ4 A0A4W2EEQ4 IL1R1 IL1R1 IL1R2 IL1R2 TNF TNF A0A4W2EGW0 A0A4W2EGW0 BMP4 BMP4 IFNG IFNG ASS1 ASS1 A0A4W2EIV4 A0A4W2EIV4 IL1B IL1B A0A4W2EKM6 A0A4W2EKM6 THBD THBD A0A4W2EQE8 A0A4W2EQE8 GSTM4 GSTM4 GSTM3 GSTM3 CALML4 CALML4 CTSL CTSL GPC1 GPC1 PIK3R3 PIK3R3 MGST1 MGST1 RAC2 RAC2 MAPK9 MAPK9 ITGAV ITGAV CHUK CHUK RHOA RHOA SRC SRC AKT1 AKT1 LOC113897645 LOC113897645 TXNDC8 TXNDC8 PIK3R2 PIK3R2 NPPC NPPC PRKCZ PRKCZ RELA RELA CTSV CTSV MMP9 MMP9 MAPK10 MAPK10 DUSP1 DUSP1 ACTL8 ACTL8 CAV3 CAV3 NFE2L2 NFE2L2 MAP2K7 MAP2K7 PRKAA1 PRKAA1 TP53 TP53 SUMO3 SUMO3 JUN JUN NFKB1 NFKB1 EDN1 EDN1 MEF2C MEF2C BMPR1A BMPR1A SUMO1 SUMO1 A0A4W2BZP2 A0A4W2BZP2 GSTO2 GSTO2 MMP20 MMP20 LOC113882304 LOC113882304 IKBKB IKBKB BCL2 BCL2 A0A4W2BSH8 A0A4W2BSH8 ACVR2B ACVR2B CTNNB1 CTNNB1 MAPK11 MAPK11 A0A4W2C102 A0A4W2C102 MGST2 MGST2 MAP2K4 MAP2K4 PDGFB PDGFB SUMO2 SUMO2 PDGFA PDGFA CYBA CYBA RAC3 RAC3 HSP90AA1 HSP90AA1 PIK3R1 PIK3R1 MEF2A MEF2A NCF2 NCF2 RAC1 RAC1 MMP2 MMP2 A0A4W2CEF6 A0A4W2CEF6 MAPK12 MAPK12 IL1A IL1A A0A4W2CGI4 A0A4W2CGI4 GSTO1 GSTO1 AKT2 AKT2 CAV2 CAV2 CAV1 CAV1 MAPK7 MAPK7 PTK2 PTK2 TRPV4 TRPV4 SDC2 SDC2 SDC4 SDC4 LOC113907256 LOC113907256 A0A4W2CR94 A0A4W2CR94 PIK3CD PIK3CD SELE SELE MAP3K5 MAP3K5 A0A4W2CZ95 A0A4W2CZ95 VCAM1 VCAM1 CALM1 CALM1 NOS3 NOS3 MAPK8 MAPK8 PIAS4 PIAS4 A0A4W2D7B2 A0A4W2D7B2 A0A4W2D833 A0A4W2D833 MAP2K5 MAP2K5 KDR KDR SQSTM1 SQSTM1 PRKAA2 PRKAA2 A0A4W2DES2 A0A4W2DES2 SDC1 SDC1 KLF2 KLF2 BMPR1B BMPR1B HMOX1 HMOX1 FOS FOS MGST3 MGST3 HSP90B1 HSP90B1 PTTG1IP PTTG1IP A0A4W2DNF6 A0A4W2DNF6 A0A4W2DNG0 A0A4W2DNG0 A0A4W2DPM7 A0A4W2DPM7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NCF1Neutrophil cytosolic factor 1. (392 aa)
CCL2C-C motif chemokine. (99 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1223 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TNFRSF1ATNF receptor superfamily member 1A. (471 aa)
ACTBActin beta. (375 aa)
TXN2Thioredoxin domain-containing protein. (221 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (394 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
KEAP1Kelch like ECH associated protein 1. (623 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ACTBL2Actin beta like 2. (376 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (274 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (868 aa)
A0A4W2E9P7Uncharacterized protein. (244 aa)
LOC113886404GST C-terminal domain-containing protein. (274 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
A0A4W2EEQ4Ubiquitin-like domain-containing protein. (72 aa)
IL1R1Interleukin 1 receptor type 1. (573 aa)
IL1R2Interleukin 1 receptor type 2. (400 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
A0A4W2EGW0Ubiquitin-like domain-containing protein. (80 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
ASS1Argininosuccinate synthase 1. (418 aa)
A0A4W2EIV4EF-hand domain-containing protein; Belongs to the calmodulin family. (87 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
A0A4W2EKM6Small ubiquitin-related modifier. (104 aa)
THBDThrombomodulin. (637 aa)
A0A4W2EQE8Rad60-SLD domain-containing protein. (83 aa)
GSTM4Glutathione S-transferase mu 4. (264 aa)
GSTM3Glutathione S-transferase. (257 aa)
CALML4Calmodulin like 4. (153 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (367 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (610 aa)
PIK3R3Uncharacterized protein. (461 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
RAC2Rac family small GTPase 2. (209 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
RHOARas homolog family member A. (193 aa)
SRCTyrosine-protein kinase. (559 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
LOC113897645Thioredoxin; Belongs to the thioredoxin family. (105 aa)
TXNDC8Thioredoxin domain containing 8. (127 aa)
PIK3R2Uncharacterized protein. (724 aa)
NPPCNatriuretic peptide C. (193 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (334 aa)
MMP9Matrix metallopeptidase 9. (712 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
ACTL8Actin like 8; Belongs to the actin family. (365 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (642 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (658 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
SUMO3Ubiquitin-like domain-containing protein. (134 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
NFKB1Nuclear factor kappa B subunit 1. (974 aa)
EDN1Endothelin 1. (202 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
A0A4W2BZP2Uncharacterized protein. (115 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (244 aa)
MMP20Matrix metallopeptidase 20. (483 aa)
LOC113882304Glutathione S-transferase. (291 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
A0A4W2BSH8Thioredoxin domain-containing protein. (545 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (830 aa)
CTNNB1Catenin beta 1. (774 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
A0A4W2C102Glutathione S-transferase. (222 aa)
MGST2Microsomal glutathione S-transferase 2. (155 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (412 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SUMO2Small ubiquitin-related modifier. (95 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (401 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (191 aa)
RAC3Rac family small GTPase 3. (258 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (774 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MEF2AMyocyte enhancer factor 2A. (503 aa)
NCF2Neutrophil cytosolic factor 2. (575 aa)
RAC1Rac family small GTPase 1. (257 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
A0A4W2CEF6Integrin beta; Belongs to the integrin beta chain family. (784 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
A0A4W2CGI4Uncharacterized protein. (222 aa)
GSTO1Glutathione S-transferase omega 1; Belongs to the GST superfamily. (344 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (211 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (781 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1139 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (803 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (202 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (218 aa)
LOC113907256Uncharacterized protein; Belongs to the GST superfamily. (239 aa)
A0A4W2CR94Uncharacterized protein; Belongs to the GST superfamily. (322 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
SELESelectin E. (510 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1366 aa)
A0A4W2CZ95Uncharacterized protein. (506 aa)
VCAM1Vascular cell adhesion molecule 1. (740 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (365 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PIAS4Protein inhibitor of activated STAT 4. (573 aa)
A0A4W2D7B2Uncharacterized protein. (83 aa)
A0A4W2D833Ubiquitin-like domain-containing protein. (61 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (463 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
SQSTM1Sequestosome 1. (529 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
A0A4W2DES2Uncharacterized protein. (116 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (322 aa)
KLF2Kruppel like factor 2. (566 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (526 aa)
HMOX1Heme oxygenase 1. (302 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MGST3Microsomal glutathione S-transferase 3. (209 aa)
HSP90B1Heat shock protein 90 beta family member 1. (808 aa)
PTTG1IPPSI domain-containing protein. (282 aa)
A0A4W2DNF6Ig-like domain-containing protein. (488 aa)
A0A4W2DNG0Ig-like domain-containing protein. (591 aa)
A0A4W2DPM7TPR_REGION domain-containing protein. (325 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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