STRINGSTRING
MAGI1 MAGI1 EZR EZR SCNN1G SCNN1G H0WHI0_OTOGA H0WHI0_OTOGA ARRDC2 ARRDC2 PRKCZ PRKCZ CFTR CFTR RASSF4 RASSF4 ARRDC1 ARRDC1 FRMD4B FRMD4B YAP1 YAP1 TEAD3 TEAD3 PATJ PATJ ARRDC3 ARRDC3 HECW2 HECW2 DUSP5 DUSP5 NUMBL NUMBL H0WMW6_OTOGA H0WMW6_OTOGA AMOTL1 AMOTL1 PARD3 PARD3 RASSF2 RASSF2 WWP2 WWP2 TEAD4 TEAD4 PARD6B PARD6B PRKCI PRKCI VGLL1 VGLL1 LATS2 LATS2 MPDZ MPDZ MAGIX MAGIX WWC1 WWC1 DTX4 DTX4 STK4 STK4 FRMD6 FRMD6 MSN MSN CLCN5 CLCN5 FRMD4A FRMD4A MOB1B MOB1B MAGI2 MAGI2 CLCN3 CLCN3 CRB3 CRB3 H0WY19_OTOGA H0WY19_OTOGA MPP3 MPP3 H0WYD2_OTOGA H0WYD2_OTOGA PTPN21 PTPN21 NUMB NUMB LNX1 LNX1 VWDE VWDE TEAD2 TEAD2 H0X220_OTOGA H0X220_OTOGA ARHGAP17 ARHGAP17 SCNN1B SCNN1B CRB1 CRB1 TEAD1 TEAD1 AMOT AMOT WWC2 WWC2 SCNN1A SCNN1A WWP1 WWP1 LATS1 LATS1 ARHGAP44 ARHGAP44 MPP7 MPP7 RDX RDX HECW1 HECW1 ARRDC4 ARRDC4 PLEKHA7 PLEKHA7 NEDD4 NEDD4 GOPC GOPC LNX2 LNX2 H0XCB6_OTOGA H0XCB6_OTOGA NEDD4L NEDD4L NDFIP1 NDFIP1 VGLL4 VGLL4 STK3 STK3 NF2 NF2 ITCH ITCH PTPN14 PTPN14 PLEKHA4 PLEKHA4 PARD3B PARD3B INAVA INAVA H0XLI4_OTOGA H0XLI4_OTOGA H0XLJ8_OTOGA H0XLJ8_OTOGA CRB2 CRB2 GRASP GRASP PARD6A PARD6A SLC9A3R1 SLC9A3R1 CFAP300 CFAP300 PARD6G PARD6G H0XRZ3_OTOGA H0XRZ3_OTOGA H0XSL3_OTOGA H0XSL3_OTOGA DTX1 DTX1 MPP5 MPP5 RASSF1 RASSF1 FAM181B FAM181B DUSP4 DUSP4 KCNJ1 KCNJ1 SLC9A3R2 SLC9A3R2 SAV1 SAV1 MAP1S MAP1S DDN DDN H0Y1C5_OTOGA H0Y1C5_OTOGA WWTR1 WWTR1 AMOTL2 AMOTL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAGI1Membrane associated guanylate kinase, WW and PDZ domain containing 1. (1327 aa)
EZRFERM domain-containing protein. (586 aa)
SCNN1GSodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (652 aa)
H0WHI0_OTOGAUncharacterized protein. (460 aa)
ARRDC2Arrestin domain containing 2. (407 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1468 aa)
RASSF4Ras association domain family member 4. (331 aa)
ARRDC1Arrestin domain containing 1. (433 aa)
FRMD4BFERM domain containing 4B. (988 aa)
YAP1Yes associated protein 1. (501 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (471 aa)
PATJPATJ crumbs cell polarity complex component. (1825 aa)
ARRDC3Arrestin domain containing 3. (416 aa)
HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1572 aa)
DUSP5Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (291 aa)
NUMBLNUMB like endocytic adaptor protein. (600 aa)
H0WMW6_OTOGAUncharacterized protein. (212 aa)
AMOTL1Angiomotin like 1. (936 aa)
PARD3Par-3 family cell polarity regulator. (1058 aa)
RASSF2Ras association domain family member 2. (326 aa)
WWP2E3 ubiquitin-protein ligase. (870 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (434 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (609 aa)
VGLL1Vestigial like family member 1. (259 aa)
LATS2Non-specific serine/threonine protein kinase. (1071 aa)
MPDZMultiple PDZ domain crumbs cell polarity complex component. (2085 aa)
MAGIXMAGI family member, X-linked. (339 aa)
WWC1WW and C2 domain containing 1. (1180 aa)
DTX4Deltex E3 ubiquitin ligase 4. (638 aa)
STK4Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa)
FRMD6FERM domain containing 6. (622 aa)
MSNMoesin. (573 aa)
CLCN5Chloride channel protein. (816 aa)
FRMD4AFERM domain containing 4A. (889 aa)
MOB1BMOB kinase activator 1B. (221 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1207 aa)
CLCN3Chloride channel protein. (866 aa)
CRB3Crumbs cell polarity complex component 3. (125 aa)
H0WY19_OTOGAUncharacterized protein. (597 aa)
MPP3Membrane palmitoylated protein 3; Belongs to the MAGUK family. (598 aa)
H0WYD2_OTOGAUncharacterized protein. (383 aa)
PTPN21Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1150 aa)
NUMBNUMB endocytic adaptor protein. (615 aa)
LNX1Ligand of numb-protein X 1. (733 aa)
VWDEVon Willebrand factor D and EGF domains. (1569 aa)
TEAD2TEA domain transcription factor 2. (449 aa)
H0X220_OTOGAUncharacterized protein. (242 aa)
ARHGAP17Rho GTPase activating protein 17. (880 aa)
SCNN1BSodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (636 aa)
CRB1Crumbs cell polarity complex component 1. (1334 aa)
TEAD1TEA domain transcription factor 1. (371 aa)
AMOTAngiomotin. (1073 aa)
WWC2WW and C2 domain containing 2. (1152 aa)
SCNN1ASodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (687 aa)
WWP1E3 ubiquitin-protein ligase. (924 aa)
LATS1Large tumor suppressor kinase 1. (1133 aa)
ARHGAP44Rho GTPase activating protein 44. (802 aa)
MPP7Membrane palmitoylated protein 7; Belongs to the MAGUK family. (547 aa)
RDXRadixin. (583 aa)
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1573 aa)
ARRDC4Arrestin domain containing 4. (414 aa)
PLEKHA7Pleckstrin homology domain containing A7. (1200 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1291 aa)
GOPCPDZ domain-containing protein. (463 aa)
LNX2Ligand of numb-protein X 2. (688 aa)
H0XCB6_OTOGAPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (522 aa)
NEDD4LE3 ubiquitin-protein ligase. (877 aa)
NDFIP1Nedd4 family interacting protein 1. (222 aa)
VGLL4Vestigial like family member 4. (269 aa)
STK3Serine/threonine kinase 3. (450 aa)
NF2Neurofibromin 2. (553 aa)
ITCHE3 ubiquitin-protein ligase. (853 aa)
PTPN14Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1182 aa)
PLEKHA4Pleckstrin homology domain containing A4. (776 aa)
PARD3BPar-3 family cell polarity regulator beta. (1193 aa)
INAVAInnate immunity activator. (663 aa)
H0XLI4_OTOGAUncharacterized protein. (186 aa)
H0XLJ8_OTOGAUncharacterized protein. (77 aa)
CRB2Crumbs cell polarity complex component 2. (1275 aa)
GRASPGeneral receptor for phosphoinositides 1 associated scaffold protein. (363 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (364 aa)
CFAP300Cilia and flagella associated protein 300. (267 aa)
PARD6GPar-6 family cell polarity regulator gamma. (367 aa)
H0XRZ3_OTOGAFERM domain-containing protein. (446 aa)
H0XSL3_OTOGAUncharacterized protein. (125 aa)
DTX1Deltex E3 ubiquitin ligase 1. (622 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
RASSF1Ras association domain family member 1. (348 aa)
FAM181BFamily with sequence similarity 181 member B. (421 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
KCNJ1Potassium voltage-gated channel subfamily J member 1. (391 aa)
SLC9A3R2Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (337 aa)
SAV1Salvador family WW domain containing protein 1. (385 aa)
MAP1SMicrotubule associated protein 1S. (1060 aa)
DDNDendrin. (714 aa)
H0Y1C5_OTOGAPH domain-containing protein. (968 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
AMOTL2Angiomotin like 2. (834 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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