STRINGSTRING
SNX8 SNX8 VPS35 VPS35 EHD3 EHD3 SNX9 SNX9 ZFYVE19 ZFYVE19 AMPH AMPH AP1S1 AP1S1 REPS2 REPS2 SYNRG SYNRG MFN1 MFN1 GAS7 GAS7 EPS15 EPS15 AP3M2 AP3M2 EEA1 EEA1 CLTCL1 CLTCL1 HIP1 HIP1 MFF MFF DNMBP DNMBP RABEP1 RABEP1 AP2A2 AP2A2 SNX1 SNX1 AP3B1 AP3B1 ITSN2 ITSN2 LOC100953429 LOC100953429 ENTHD1 ENTHD1 AP1G1 AP1G1 BIN1 BIN1 SNX4 SNX4 DNM1 DNM1 CFAP70 CFAP70 SARAF SARAF RAB5A RAB5A SNX10 SNX10 PREX2 PREX2 CLHC1 CLHC1 CLDN10 CLDN10 AP4S1 AP4S1 NECAP2 NECAP2 TUFT1 TUFT1 SNX27 SNX27 STON2 STON2 IGF2R IGF2R MFN2 MFN2 H0WRX6_OTOGA H0WRX6_OTOGA OMA1 OMA1 OPA1 OPA1 AP2B1 AP2B1 VPS26A VPS26A EPN1 EPN1 TBC1D16 TBC1D16 SNX5 SNX5 ARL5B ARL5B VPS45 VPS45 NECAP1 NECAP1 AP4M1 AP4M1 FCHO1 FCHO1 SGIP1 SGIP1 MX2 MX2 RABEP2 RABEP2 WDFY4 WDFY4 VPS29 VPS29 RAB5B RAB5B TBRG4 TBRG4 CLDN15 CLDN15 BIN2 BIN2 GGA3 GGA3 H0WXV6_OTOGA H0WXV6_OTOGA GGA1 GGA1 RAB4A RAB4A EPS15L1 EPS15L1 RUFY3 RUFY3 AP1G2 AP1G2 RINL RINL ANKFY1 ANKFY1 H0WZC7_OTOGA H0WZC7_OTOGA AAK1 AAK1 SNX12 SNX12 SORL1 SORL1 EHD1 EHD1 SORCS2 SORCS2 RAB5C RAB5C EPN3 EPN3 MX1 MX1 TNK2 TNK2 DKKL1 DKKL1 RAB20 RAB20 AP3B2 AP3B2 BIN3 BIN3 MANSC4 MANSC4 ALS2 ALS2 PRKN PRKN DNM2 DNM2 AFTPH AFTPH AP1S2 AP1S2 DNM1L DNM1L RIN2 RIN2 DNM3 DNM3 EPN2 EPN2 H0X6G8_OTOGA H0X6G8_OTOGA SNX3 SNX3 SNAP91 SNAP91 RUFY2 RUFY2 RUFY1 RUFY1 ABL2 ABL2 RAB17 RAB17 PINK1 PINK1 HIP1R HIP1R PICALM PICALM RBSN RBSN TNK1 TNK1 AP3D1 AP3D1 AP1M2 AP1M2 SNX7 SNX7 FCHO2 FCHO2 BMP2K BMP2K RABGAP1 RABGAP1 RAB31 RAB31 UBQLN3 UBQLN3 AP1S3 AP1S3 GGA2 GGA2 VPS26B VPS26B GAK GAK RAB22A RAB22A ITSN1 ITSN1 DNAJC6 DNAJC6 AP1M1 AP1M1 EHD4 EHD4 TBC1D5 TBC1D5 ARPIN ARPIN SNX2 SNX2 PXDC1 PXDC1 SNX32 SNX32 AP2A1 AP2A1 AP3M1 AP3M1 REPS1 REPS1 SNX33 SNX33 H0XHC2_OTOGA H0XHC2_OTOGA SNX18 SNX18 ZFAND5 ZFAND5 AP3S1 AP3S1 H0XJ77_OTOGA H0XJ77_OTOGA ZFAND3 ZFAND3 CLINT1 CLINT1 RIN1 RIN1 AP2M1 AP2M1 CLTA CLTA AP4E1 AP4E1 H0XM98_OTOGA H0XM98_OTOGA H0XN29_OTOGA H0XN29_OTOGA SNX6 SNX6 H0XQD7_OTOGA H0XQD7_OTOGA RAB24 RAB24 H0XQH5_OTOGA H0XQH5_OTOGA H0XQI6_OTOGA H0XQI6_OTOGA H0XQJ8_OTOGA H0XQJ8_OTOGA MARCHF5 MARCHF5 H0XQU8_OTOGA H0XQU8_OTOGA USP6NL USP6NL MIEF2 MIEF2 H0XS28_OTOGA H0XS28_OTOGA SNX30 SNX30 AP4B1 AP4B1 H0XVC8_OTOGA H0XVC8_OTOGA CLTB CLTB AP3S2 AP3S2 CLTC CLTC EHD2 EHD2 ZHX2 ZHX2 AP1B1 AP1B1 VGF VGF RIN3 RIN3 AP2S1 AP2S1 H0XXJ6_OTOGA H0XXJ6_OTOGA RAB4B RAB4B LOC100950940 LOC100950940 LOC100955604 LOC100955604 H0Y1J2_OTOGA H0Y1J2_OTOGA H0Y1U3_OTOGA H0Y1U3_OTOGA H0Y242_OTOGA H0Y242_OTOGA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNX8Sorting nexin 8. (429 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
EHD3EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
SNX9Sorting nexin. (594 aa)
ZFYVE19Zinc finger FYVE-type containing 19. (400 aa)
AMPHAmphiphysin. (623 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (177 aa)
REPS2Uncharacterized protein. (570 aa)
SYNRGSynergin gamma. (862 aa)
MFN1Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (744 aa)
GAS7Growth arrest specific 7. (412 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (899 aa)
AP3M2AP-3 complex subunit mu-2. (418 aa)
EEA1Early endosome antigen 1. (1411 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1639 aa)
HIP1Huntingtin interacting protein 1. (951 aa)
MFFMitochondrial fission factor. (341 aa)
DNMBPDynamin binding protein. (1578 aa)
RABEP1Rabaptin, RAB GTPase binding effector protein 1. (850 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (930 aa)
SNX1Sorting nexin 1. (522 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1083 aa)
ITSN2Intersectin 2. (1695 aa)
LOC100953429Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
ENTHD1ENTH domain containing 1. (622 aa)
AP1G1AP-1 complex subunit gamma. (823 aa)
BIN1Bridging integrator 1. (687 aa)
SNX4Sorting nexin 4. (454 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (851 aa)
CFAP70Cilia and flagella associated protein 70. (1120 aa)
SARAFStore-operated calcium entry associated regulatory factor. (340 aa)
RAB5ARAB5A, member RAS oncogene family. (208 aa)
SNX10PX domain-containing protein. (224 aa)
PREX2Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1605 aa)
CLHC1Clathrin heavy chain linker domain containing 1. (597 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
AP4S1Adaptor related protein complex 4 subunit sigma 1. (138 aa)
NECAP2NECAP endocytosis associated 2. (274 aa)
TUFT1Tuftelin 1. (387 aa)
SNX27Sorting nexin family member 27 (Predicted). (913 aa)
STON2Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family. (927 aa)
IGF2RInsulin like growth factor 2 receptor. (2453 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
H0WRX6_OTOGAUncharacterized protein. (735 aa)
OMA1OMA1 zinc metallopeptidase. (524 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1014 aa)
AP2B1Adaptor related protein complex 2 subunit beta 1. (951 aa)
VPS26AVPS26, retromer complex component A. (326 aa)
EPN1Epsin 1. (575 aa)
TBC1D16TBC1 domain family member 16. (767 aa)
SNX5Sorting nexin; Involved in several stages of intracellular trafficking. (404 aa)
ARL5BADP ribosylation factor like GTPase 5B; Belongs to the small GTPase superfamily. Arf family. (113 aa)
VPS45Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family. (543 aa)
NECAP1NECAP endocytosis associated 1. (277 aa)
AP4M1AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (453 aa)
FCHO1FCH domain only 1. (882 aa)
SGIP1SH3 domain GRB2 like endophilin interacting protein 1; Belongs to the adaptor complexes medium subunit family. (500 aa)
MX2MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (709 aa)
RABEP2Rabaptin, RAB GTPase binding effector protein 2. (560 aa)
WDFY4WDFY family member 4. (3200 aa)
VPS29Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (186 aa)
RAB5BRAB5B, member RAS oncogene family. (161 aa)
TBRG4Transforming growth factor beta regulator 4. (632 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
BIN2Bridging integrator 2. (563 aa)
GGA3Golgi associated, gamma adaptin ear containing, ARF binding protein 3. (664 aa)
H0WXV6_OTOGAUncharacterized protein. (706 aa)
GGA1Golgi associated, gamma adaptin ear containing, ARF binding protein 1. (660 aa)
RAB4ARAB4A, member RAS oncogene family. (218 aa)
EPS15L1Epidermal growth factor receptor pathway substrate 15 like 1. (909 aa)
RUFY3RUN and FYVE domain containing 3. (615 aa)
AP1G2AP-1 complex subunit gamma. (785 aa)
RINLRas and Rab interactor like. (560 aa)
ANKFY1Ankyrin repeat and FYVE domain containing 1. (1115 aa)
H0WZC7_OTOGARas-GAP domain-containing protein. (932 aa)
AAK1AP2 associated kinase 1. (957 aa)
SNX12Sorting nexin 12. (162 aa)
SORL1Sortilin related receptor 1. (2216 aa)
EHD1EH-domain containing 1 (Predicted); Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (534 aa)
SORCS2Sortilin related VPS10 domain containing receptor 2. (959 aa)
RAB5CRAB5C, member RAS oncogene family. (216 aa)
EPN3Epsin 3. (657 aa)
MX1MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (590 aa)
TNK2Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1085 aa)
DKKL1Dickkopf like acrosomal protein 1. (241 aa)
RAB20RAB20, member RAS oncogene family. (234 aa)
AP3B2AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1102 aa)
BIN3Bridging integrator 3. (255 aa)
MANSC4MANSC domain containing 4. (333 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1651 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (463 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (817 aa)
AFTPHAftiphilin. (909 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (763 aa)
RIN2Ras and Rab interactor 2. (847 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (636 aa)
EPN2Epsin 2. (579 aa)
H0X6G8_OTOGAUncharacterized protein. (854 aa)
SNX3Sorting nexin 3. (159 aa)
SNAP91Synaptosome associated protein 91. (877 aa)
RUFY2RUN and FYVE domain containing 2. (641 aa)
RUFY1RUN and FYVE domain containing 1. (600 aa)
ABL2Tyrosine-protein kinase. (1108 aa)
RAB17RAB17, member RAS oncogene family. (212 aa)
PINK1PTEN induced kinase 1. (581 aa)
HIP1RHuntingtin interacting protein 1 related. (1080 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (722 aa)
RBSNRabenosyn, RAB effector. (784 aa)
TNK1Tyrosine kinase non receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (667 aa)
AP3D1AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1250 aa)
AP1M2AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (423 aa)
SNX7Sorting nexin 7. (387 aa)
FCHO2FCH domain only 2. (780 aa)
BMP2KBMP2 inducible kinase. (1103 aa)
RABGAP1RAB GTPase activating protein 1. (1069 aa)
RAB31RAB31, member RAS oncogene family. (194 aa)
UBQLN3Ubiquilin 3 (Predicted). (654 aa)
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
GGA2Golgi associated, gamma adaptin ear containing, ARF binding protein 2. (609 aa)
VPS26BVPS26, retromer complex component B. (335 aa)
GAKCyclin G associated kinase. (1307 aa)
RAB22ARAB22A, member RAS oncogene family. (194 aa)
ITSN1Intersectin 1. (1716 aa)
DNAJC6DnaJ heat shock protein family (Hsp40) member C6. (907 aa)
AP1M1AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (423 aa)
EHD4EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (541 aa)
TBC1D5TBC1 domain family member 5. (768 aa)
ARPINUncharacterized protein. (226 aa)
SNX2Sorting nexin 2. (512 aa)
PXDC1PX domain containing 1. (231 aa)
SNX32Sorting nexin; Involved in several stages of intracellular trafficking. (409 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (946 aa)
AP3M1AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes; Belongs to the adaptor complexes medium subunit family. (418 aa)
REPS1RALBP1 associated Eps domain containing 1. (796 aa)
SNX33Sorting nexin. (574 aa)
H0XHC2_OTOGAUncharacterized protein. (272 aa)
SNX18Sorting nexin. (624 aa)
ZFAND5Zinc finger AN1-type containing 5. (213 aa)
AP3S1Adaptor related protein complex 3 subunit sigma 1. (193 aa)
H0XJ77_OTOGAUncharacterized protein. (97 aa)
ZFAND3Zinc finger AN1-type containing 3. (217 aa)
CLINT1Clathrin interactor 1. (644 aa)
RIN1Ras and Rab interactor 1. (613 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (437 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (217 aa)
AP4E1AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. (1137 aa)
H0XM98_OTOGAUncharacterized protein. (54 aa)
H0XN29_OTOGATcp10_C domain-containing protein. (127 aa)
SNX6Sorting nexin; Involved in several stages of intracellular trafficking. (413 aa)
H0XQD7_OTOGAPX domain-containing protein. (406 aa)
RAB24RAB24, member RAS oncogene family. (203 aa)
H0XQH5_OTOGAHyaluronidase. (472 aa)
H0XQI6_OTOGAAP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
H0XQJ8_OTOGAVPS9 domain-containing protein. (485 aa)
MARCHF5Membrane associated ring-CH-type finger 5. (283 aa)
H0XQU8_OTOGAUncharacterized protein. (460 aa)
USP6NLUSP6 N-terminal like. (821 aa)
MIEF2Mitochondrial elongation factor 2. (454 aa)
H0XS28_OTOGABMP2K_C domain-containing protein. (355 aa)
SNX30Sorting nexin family member 30. (393 aa)
AP4B1AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (739 aa)
H0XVC8_OTOGAPID domain-containing protein. (363 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (263 aa)
AP3S2Adaptor related protein complex 3 subunit sigma 2. (193 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1673 aa)
EHD2EH domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (543 aa)
ZHX2Zinc fingers and homeoboxes 2. (837 aa)
AP1B1AP complex subunit beta. (947 aa)
VGFVGF nerve growth factor inducible. (617 aa)
RIN3Ras and Rab interactor 3. (981 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
H0XXJ6_OTOGAENTH domain-containing protein. (239 aa)
RAB4BUncharacterized protein. (213 aa)
LOC100950940Clathrin_bdg domain-containing protein. (906 aa)
LOC100955604Uncharacterized protein. (208 aa)
H0Y1J2_OTOGAMetallophos_2 domain-containing protein. (168 aa)
H0Y1U3_OTOGAPX domain-containing protein. (333 aa)
H0Y242_OTOGAEH domain-containing protein. (461 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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