STRINGSTRING
USP4 USP4 H0WLN3_OTOGA H0WLN3_OTOGA SNRPE SNRPE PRMT5 PRMT5 PRPF3 PRPF3 SRSF12 SRSF12 PRPF31 PRPF31 SNRPD1 SNRPD1 GEMIN2 GEMIN2 CLNS1A CLNS1A GEMIN6 GEMIN6 DDX20 DDX20 PRMT7 PRMT7 TGS1 TGS1 H0X7Q6_OTOGA H0X7Q6_OTOGA STRAP STRAP H0XAZ5_OTOGA H0XAZ5_OTOGA GEMIN7 GEMIN7 SART3 SART3 SNRPG SNRPG SRSF10 SRSF10 SNRPB SNRPB SART1 SART1 CD2BP2 CD2BP2 PRPF19 PRPF19 GEMIN5 GEMIN5 H0XHN9_OTOGA H0XHN9_OTOGA LSM4 LSM4 COIL COIL LOC100966575 LOC100966575 H0XQD3_OTOGA H0XQD3_OTOGA H0XQW7_OTOGA H0XQW7_OTOGA LOC100957263 LOC100957263 SNRPD3 SNRPD3 SNRPD2 SNRPD2 GEMIN4 GEMIN4 SNRPC SNRPC SNRPC-2 SNRPC-2 WDR77 WDR77 SNRPC-3 SNRPC-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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USP4Ubiquitin specific peptidase 4; Belongs to the peptidase C19 family. (952 aa)
H0WLN3_OTOGAUncharacterized protein. (241 aa)
SNRPESmall nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (76 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa)
PRPF3Pre-mRNA processing factor 3. (682 aa)
SRSF12Serine and arginine rich splicing factor 12. (240 aa)
PRPF31PRP31 pre-mRNA processing factor 31 homolog (Predicted). (307 aa)
SNRPD1Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. (119 aa)
GEMIN2Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family. (280 aa)
CLNS1AChloride nucleotide-sensitive channel 1A. (157 aa)
GEMIN6Gem nuclear organelle associated protein 6. (167 aa)
DDX20DEAD-box helicase 20. (821 aa)
PRMT7Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (694 aa)
TGS1Trimethylguanosine synthase 1. (853 aa)
H0X7Q6_OTOGAU6-snRNA_bdg domain-containing protein. (129 aa)
STRAPSerine/threonine kinase receptor associated protein. (347 aa)
H0XAZ5_OTOGASm domain-containing protein. (53 aa)
GEMIN7Gem nuclear organelle associated protein 7. (131 aa)
SART3Spliceosome associated factor 3, U4/U6 recycling protein. (968 aa)
SNRPGSmall nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (73 aa)
SRSF10Serine and arginine rich splicing factor 10. (223 aa)
SNRPBSmall nuclear ribonucleoprotein-associated protein. (240 aa)
SART1Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (801 aa)
CD2BP2CD2 cytoplasmic tail binding protein 2. (340 aa)
PRPF19Pre-mRNA processing factor 19. (506 aa)
GEMIN5Gem nuclear organelle associated protein 5. (1509 aa)
H0XHN9_OTOGAUncharacterized protein. (237 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (146 aa)
COILCoilin. (571 aa)
LOC100966575Uncharacterized protein. (239 aa)
H0XQD3_OTOGAUncharacterized protein. (239 aa)
H0XQW7_OTOGATudor domain-containing protein. (288 aa)
LOC100957263Sm domain-containing protein. (86 aa)
SNRPD3Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (148 aa)
SNRPD2Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (117 aa)
GEMIN4Gem nuclear organelle associated protein 4. (1057 aa)
SNRPCU1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] (152 aa)
SNRPC-2U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] (178 aa)
WDR77WD repeat domain 77. (342 aa)
SNRPC-3U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] (159 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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