STRINGSTRING
GDNF GDNF SIX1 SIX1 WNT2 WNT2 WNT2B WNT2B CTNNB1 CTNNB1 FGF8 FGF8 SPRY1 SPRY1 HOXC11 HOXC11 BMP4 BMP4 FGF2 FGF2 FGF10 FGF10 HOXA11 HOXA11 FRS2 FRS2 FGF1 FGF1 BMP2 BMP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GDNFGlial cell derived neurotrophic factor. (228 aa)
SIX1SIX homeobox 1. (349 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
CTNNB1Catenin beta 1. (781 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
HOXC11Homeobox C11. (373 aa)
BMP4Bone morphogenetic protein 4 (Predicted). (409 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
HOXA11Homeobox A11 (Predicted). (314 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
BMP2Bone morphogenetic protein 2. (393 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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