STRINGSTRING
NRG2 NRG2 THPO THPO IL2 IL2 H0Y238_OTOGA H0Y238_OTOGA GDF7 GDF7 GDF2 GDF2 FGF2 FGF2 AREG AREG NTF4 NTF4 SPEM2 SPEM2 H0XZG2_OTOGA H0XZG2_OTOGA FGF9 FGF9 FGF13 FGF13 BMP6 BMP6 NGF NGF OSGIN1 OSGIN1 BMP4 BMP4 VGF VGF CCN2 CCN2 PDGFA PDGFA CLEC11A CLEC11A GDF6 GDF6 TGFB1 TGFB1 H0XTZ8_OTOGA H0XTZ8_OTOGA H0XTW2_OTOGA H0XTW2_OTOGA CXCL12 CXCL12 TFF1 TFF1 GDF3 GDF3 AMBN AMBN IGF2 IGF2 FGF3 FGF3 HDGFL1 HDGFL1 GDF5 GDF5 H0XQJ1_OTOGA H0XQJ1_OTOGA PSPN PSPN GDF15 GDF15 AMH AMH FGF19 FGF19 ARTN ARTN OSGIN2 OSGIN2 MANF MANF FGF8 FGF8 MACC1 MACC1 TYMP TYMP CSF1 CSF1 BTC BTC H0XI62_OTOGA H0XI62_OTOGA INHBB INHBB BDNF BDNF TDGF1 TDGF1 GFER GFER NRTN NRTN GMFG GMFG JAG2 JAG2 BMP5 BMP5 EPGN EPGN IL4 IL4 IL5 IL5 GRN GRN THBS4 THBS4 OGN OGN H0XBQ8_OTOGA H0XBQ8_OTOGA BMP7 BMP7 IL12B IL12B FGF18 FGF18 FGF7 FGF7 MSTN MSTN PDGFC PDGFC IL12A IL12A LIF LIF GDF1 GDF1 FGF11 FGF11 CSPG5 CSPG5 GKN1 GKN1 BMP10 BMP10 OSM OSM NRG1 NRG1 HDGFL3 HDGFL3 FGF4 FGF4 FGF14 FGF14 SPEM1 SPEM1 FBRS FBRS BMP3 BMP3 FGF5 FGF5 JAG1 JAG1 PTN PTN CSF3 CSF3 H0X388_OTOGA H0X388_OTOGA CLCF1 CLCF1 CSF2 CSF2 TGFB2 TGFB2 FGF12 FGF12 PDGFD PDGFD FAM71F1 FAM71F1 FAM71F2 FAM71F2 FGF16 FGF16 GMFB GMFB KITLG KITLG IL9 IL9 NTF3 NTF3 GDF9 GDF9 TGFB3 TGFB3 ANGPTL3 ANGPTL3 PROK1 PROK1 PGF PGF FGF22 FGF22 CCN3 CCN3 CNTF CNTF PDGFB PDGFB EFEMP1 EFEMP1 IL34 IL34 H0WG79_OTOGA H0WG79_OTOGA INHA INHA FGF10 FGF10 TIMP1 TIMP1 GDNF GDNF RABEP1 RABEP1 GDF11 GDF11 GDF10 GDF10 H0WJJ9_OTOGA H0WJJ9_OTOGA MDK MDK EREG EREG LOC100958496 LOC100958496 VEGFD VEGFD IGF1 IGF1 HBEGF HBEGF FGF21 FGF21 VEGFC VEGFC INHBA INHBA IL11 IL11 H0WPC6_OTOGA H0WPC6_OTOGA DKK1 DKK1 EGF EGF CDNF CDNF FGF17 FGF17 BMP1 BMP1 FGF1 FGF1 FGF23 FGF23 FGF6 FGF6 INHBC INHBC INHBE INHBE FGF20 FGF20 ENDOU ENDOU NODAL NODAL HGF HGF BMP2 BMP2 CD320 CD320 TGFA TGFA RABEP2 RABEP2 VEGFB VEGFB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRG2Neuregulin 2. (604 aa)
THPOThrombopoietin. (297 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
H0Y238_OTOGAUncharacterized protein. (72 aa)
GDF7Growth differentiation factor 7. (421 aa)
GDF2Growth differentiation factor 2. (427 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
AREGAmphiregulin. (253 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
SPEM2SPEM family member 2. (503 aa)
H0XZG2_OTOGASH3 domain-containing protein. (131 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
BMP6Bone morphogenetic protein 6. (516 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (244 aa)
OSGIN1Oxidative stress induced growth inhibitor 1. (478 aa)
BMP4Bone morphogenetic protein 4 (Predicted). (409 aa)
VGFVGF nerve growth factor inducible. (617 aa)
CCN2Cellular communication network factor 2. (349 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
CLEC11AC-type lectin domain containing 11A. (322 aa)
GDF6Growth differentiation factor 6. (461 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (403 aa)
H0XTZ8_OTOGATGF_BETA_2 domain-containing protein. (420 aa)
H0XTW2_OTOGAC-X-C motif chemokine. (129 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (80 aa)
TFF1Trefoil factor 1. (88 aa)
GDF3Growth differentiation factor 3. (366 aa)
AMBNAmeloblastin. (444 aa)
IGF2Insulin-like growth factor II (Predicted). (54 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
HDGFL1HDGF like 1. (236 aa)
GDF5Growth differentiation factor 5. (498 aa)
H0XQJ1_OTOGATGF_BETA_2 domain-containing protein. (414 aa)
PSPNPersephin. (156 aa)
GDF15Growth differentiation factor 15. (318 aa)
AMHAnti-Mullerian hormone. (557 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
ARTNArtemin. (222 aa)
OSGIN2Oxidative stress induced growth inhibitor family member 2. (550 aa)
MANFMesencephalic astrocyte derived neurotrophic factor. (182 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
MACC1MET transcriptional regulator MACC1. (854 aa)
TYMPThymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (485 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (545 aa)
BTCBetacellulin. (175 aa)
H0XI62_OTOGATGF_BETA_2 domain-containing protein. (341 aa)
INHBBInhibin subunit beta B. (407 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (241 aa)
TDGF1Teratocarcinoma-derived growth factor 1. (186 aa)
GFERSulfhydryl oxidase. (203 aa)
NRTNNeurturin. (197 aa)
GMFGGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (142 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1224 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
EPGNEpithelial mitogen. (151 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
GRNGranulin precursor. (600 aa)
THBS4Thrombospondin 4. (961 aa)
OGNOsteoglycin. (356 aa)
H0XBQ8_OTOGAUncharacterized protein. (116 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
MSTNMyostatin. (375 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (308 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (217 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
GDF1TGF_BETA_2 domain-containing protein. (370 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
CSPG5Chondroitin sulfate proteoglycan 5. (566 aa)
GKN1Gastrokine 1. (185 aa)
BMP10Bone morphogenetic protein 10. (425 aa)
OSMOncostatin M. (251 aa)
NRG1Neuregulin 1. (510 aa)
HDGFL3HDGF like 3. (192 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
SPEM1Spermatid maturation 1. (310 aa)
FBRSFibrosin. (984 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (476 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (269 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
PTNPleiotrophin. (168 aa)
CSF3Colony stimulating factor 3. (195 aa)
H0X388_OTOGASCY domain-containing protein. (123 aa)
CLCF1Cardiotrophin like cytokine factor 1. (215 aa)
CSF2Granulate-macrophage stimulating factor (Predicted). (143 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
PDGFDPlatelet derived growth factor D. (247 aa)
FAM71F1Family with sequence similarity 71 member F1. (340 aa)
FAM71F2Family with sequence similarity 71 member F2. (308 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (153 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (272 aa)
IL9Interleukin 9. (145 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (257 aa)
GDF9Growth differentiation factor 9 (Predicted). (452 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
PROK1Prokineticin 1. (105 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (195 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (167 aa)
CCN3Cellular communication network factor 3. (351 aa)
CNTFCiliary neurotrophic factor. (199 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (495 aa)
IL34Interleukin 34. (236 aa)
H0WG79_OTOGAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (232 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (369 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
RABEP1Rabaptin, RAB GTPase binding effector protein 1. (850 aa)
GDF11Growth differentiation factor 11. (258 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (476 aa)
H0WJJ9_OTOGAUncharacterized protein. (347 aa)
MDKMidkine. (143 aa)
EREGEpiregulin. (162 aa)
LOC100958496Left-right determination factor. (364 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (328 aa)
IGF1Insulin like growth factor 1. (189 aa)
HBEGFHeparin binding EGF like growth factor. (206 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (371 aa)
INHBAInhibin subunit beta A. (426 aa)
IL11Interleukin 11. (199 aa)
H0WPC6_OTOGAUncharacterized protein. (211 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (268 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1143 aa)
CDNFCerebral dopamine neurotrophic factor. (187 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
BMP1Metalloendopeptidase. (988 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (252 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
INHBCInhibin subunit beta C. (350 aa)
INHBEInhibin subunit beta E. (352 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ENDOUEndonuclease, poly(U) specific. (416 aa)
NODALNodal growth differentiation factor. (344 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (732 aa)
BMP2Bone morphogenetic protein 2. (393 aa)
CD320CD320 molecule. (265 aa)
TGFATransforming growth factor alpha. (169 aa)
RABEP2Rabaptin, RAB GTPase binding effector protein 2. (560 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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