(9 nodes) Spinal cord motor neuron cell fate specification network (Otolemur garnettii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	OLIG3	Oligodendrocyte transcription factor 3. (272 aa)
	MNX1	Motor neuron and pancreas homeobox 1. (289 aa)
	HOXD10	Homeobox D10. (340 aa)
	GLI3	GLI family zinc finger 3. (1462 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
	HOXC10	Homeobox C10. (342 aa)
	ISL2	ISL LIM homeobox 2. (359 aa)
	LHX3	LIM homeobox 3. (402 aa)
	ISL1	ISL LIM homeobox 1. (361 aa)

Your Current Organism:

Otolemur garnettii

NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GLI3	SUFU	ENSOGAP00000011336	ENSOGAP00000004327	GLI family zinc finger 3.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.991
ISL1	LHX3	ENSOGAP00000020197	ENSOGAP00000000647	ISL LIM homeobox 1.	LIM homeobox 3.	0.957
ISL1	MNX1	ENSOGAP00000020197	ENSOGAP00000018416	ISL LIM homeobox 1.	Motor neuron and pancreas homeobox 1.	0.544
ISL2	LHX3	ENSOGAP00000001776	ENSOGAP00000000647	ISL LIM homeobox 2.	LIM homeobox 3.	0.928
ISL2	MNX1	ENSOGAP00000001776	ENSOGAP00000018416	ISL LIM homeobox 2.	Motor neuron and pancreas homeobox 1.	0.459
LHX3	ISL1	ENSOGAP00000000647	ENSOGAP00000020197	LIM homeobox 3.	ISL LIM homeobox 1.	0.957
LHX3	ISL2	ENSOGAP00000000647	ENSOGAP00000001776	LIM homeobox 3.	ISL LIM homeobox 2.	0.928
LHX3	MNX1	ENSOGAP00000000647	ENSOGAP00000018416	LIM homeobox 3.	Motor neuron and pancreas homeobox 1.	0.401
MNX1	ISL1	ENSOGAP00000018416	ENSOGAP00000020197	Motor neuron and pancreas homeobox 1.	ISL LIM homeobox 1.	0.544
MNX1	ISL2	ENSOGAP00000018416	ENSOGAP00000001776	Motor neuron and pancreas homeobox 1.	ISL LIM homeobox 2.	0.459
MNX1	LHX3	ENSOGAP00000018416	ENSOGAP00000000647	Motor neuron and pancreas homeobox 1.	LIM homeobox 3.	0.401
SUFU	GLI3	ENSOGAP00000004327	ENSOGAP00000011336	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	GLI family zinc finger 3.	0.991