STRINGSTRING
BAD BAD H0WVM3_OTOGA H0WVM3_OTOGA STK11 STK11 GCLC GCLC FAM3B FAM3B BACE2 BACE2 DBH DBH PIK3CA PIK3CA HK3 HK3 PARK7 PARK7 SIDT2 SIDT2 INPP5K INPP5K ABCC8 ABCC8 LEPR LEPR LEP LEP HK1 HK1 HKDC1 HKDC1 SLC12A6 SLC12A6 NR1D1 NR1D1 CSRP3 CSRP3 PDK3 PDK3 TRA2B TRA2B GJB6 GJB6 CYP7A1 CYP7A1 TJP1 TJP1 MBD5 MBD5 PDK2 PDK2 FOXK2 FOXK2 FN1 FN1 SLC16A1 SLC16A1 APPL2 APPL2 SLC2A4 SLC2A4 H0WPC6_OTOGA H0WPC6_OTOGA H0WNW0_OTOGA H0WNW0_OTOGA LIN28A LIN28A KLF7 KLF7 TH TH FFAR2 FFAR2 GCGR GCGR NGFR NGFR ERN1 ERN1 FGF21 FGF21 MCU MCU CLTRN CLTRN CASR CASR PTCH1 PTCH1 INSR INSR CSMD1 CSMD1 PRKAA2 PRKAA2 ALOX5 ALOX5 FABP5 FABP5 H0WKM1_OTOGA H0WKM1_OTOGA GHRHR GHRHR SIRT6 SIRT6 TRPV4 TRPV4 MLXIPL MLXIPL STAT3 STAT3 ADCY8 ADCY8 DUPD1 DUPD1 PAX2 PAX2 ADIPOQ ADIPOQ CRY1 CRY1 H0WHZ3_OTOGA H0WHZ3_OTOGA ADIPOR2 ADIPOR2 TFAP2B TFAP2B CYBA CYBA ADGRF5 ADGRF5 PTPN11 PTPN11 AQP4 AQP4 SLC8B1 SLC8B1 FOXA1 FOXA1 FOXA3 FOXA3 TWNK TWNK PTPN2 PTPN2 H0XZF0_OTOGA H0XZF0_OTOGA KCNB1 KCNB1 VGF VGF HK2 HK2 SOX4 SOX4 CAV3 CAV3 H0XVZ9_OTOGA H0XVZ9_OTOGA GCK GCK H0XUR5_OTOGA H0XUR5_OTOGA GAS6 GAS6 MEN1 MEN1 H0XU07_OTOGA H0XU07_OTOGA INS INS H0XTL6_OTOGA H0XTL6_OTOGA SRF SRF FOXO1 FOXO1 H0XSZ0_OTOGA H0XSZ0_OTOGA ZNF236 ZNF236 SUCNR1 SUCNR1 LRRC8A LRRC8A CRTC2 CRTC2 HNF4A HNF4A POMC POMC AKT1 AKT1 RMI1 RMI1 HECTD4 HECTD4 H0XMX4_OTOGA H0XMX4_OTOGA H0XMW9_OTOGA H0XMW9_OTOGA FFAR1 FFAR1 ZBTB20 ZBTB20 NPTX1 NPTX1 AGER AGER CYB5R4 CYB5R4 ADIPOR1 ADIPOR1 BHLHA15 BHLHA15 LRRC8D LRRC8D GATA4 GATA4 IGFBP5 IGFBP5 OAS1 OAS1 PIK3R1 PIK3R1 RACK1 RACK1 RAI14 RAI14 PCK1 PCK1 GCLM GCLM PPARGC1A PPARGC1A SESN3 SESN3 TCF7L2 TCF7L2 GRIK5 GRIK5 PYGL PYGL PLSCR3 PLSCR3 PCK2 PCK2 STXBP3 STXBP3 RBP4 RBP4 WFS1 WFS1 DHPS DHPS SERPINF1 SERPINF1 CSMD2 CSMD2 RAB11FIP2 RAB11FIP2 SIRT1 SIRT1 GCG GCG CRY2 CRY2 ASPSCR1 ASPSCR1 SLC12A7 SLC12A7 GPER1 GPER1 IGF1R IGF1R SMAD4 SMAD4 CPB2 CPB2 SLC29A1 SLC29A1 PRKAA1 PRKAA1 RFX6 RFX6 H0X5E7_OTOGA H0X5E7_OTOGA FGFR4 FGFR4 PPP3CA PPP3CA GPR1 GPR1 ICAM1 ICAM1 SLC39A14 SLC39A14 NUCKS1 NUCKS1 SESN2 SESN2 SELENOT SELENOT NCOA5 NCOA5 SLC37A4 SLC37A4 FBN1 FBN1 G6PC G6PC GCKR GCKR H0WZZ9_OTOGA H0WZZ9_OTOGA SIN3A SIN3A PTPRN PTPRN RESP18 RESP18 RBM4 RBM4 HIF1A HIF1A FOXK1 FOXK1 RPS6 RPS6 RPH3AL RPH3AL PDX1 PDX1 HNF1A HNF1A CARTPT CARTPT CCDC186 CCDC186 FBN2 FBN2 PDK4 PDK4 NR1H4 NR1H4 PAX6 PAX6 TREM2 TREM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BADBCL2 associated agonist of cell death. (168 aa)
H0WVM3_OTOGAANK_REP_REGION domain-containing protein. (214 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
FAM3BFamily with sequence similarity 3 member B. (235 aa)
BACE2Beta-secretase 2; Belongs to the peptidase A1 family. (484 aa)
DBHDopamine beta-hydroxylase. (629 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
HK3Hexokinase 3. (924 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
SIDT2SID1 transmembrane family member 2. (431 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (433 aa)
ABCC8ATP binding cassette subfamily C member 8. (1594 aa)
LEPRLeptin receptor. (998 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
HK1Hexokinase 1. (917 aa)
HKDC1Hexokinase domain containing 1. (918 aa)
SLC12A6Solute carrier family 12 member 6. (1150 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
TRA2BTransformer 2 beta homolog. (293 aa)
GJB6Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (261 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (502 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1741 aa)
MBD5Methyl-CpG binding domain protein 5. (1732 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
FOXK2Forkhead box K2. (544 aa)
FN1Fibronectin 1. (1987 aa)
SLC16A1Solute carrier family 16 member 1. (500 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
H0WPC6_OTOGAUncharacterized protein. (211 aa)
H0WNW0_OTOGAUncharacterized protein. (382 aa)
LIN28ALin-28 homolog A. (209 aa)
KLF7Kruppel like factor 7. (302 aa)
THTyrosine hydroxylase. (494 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (330 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (417 aa)
NGFRNerve growth factor receptor. (430 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (903 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
MCUMitochondrial calcium uniporter. (277 aa)
CLTRNCollectrin domain-containing protein. (221 aa)
CASRCalcium sensing receptor. (1077 aa)
PTCH1Patched 1. (1447 aa)
INSRTyrosine-protein kinase receptor. (1366 aa)
CSMD1CUB and Sushi multiple domains 1. (3048 aa)
PRKAA2Non-specific serine/threonine protein kinase. (521 aa)
ALOX5Arachidonate 5-lipoxygenase. (705 aa)
FABP5Fatty acid binding protein 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
H0WKM1_OTOGAANK_REP_REGION domain-containing protein. (201 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (341 aa)
SIRT6Sirtuin 6. (359 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
MLXIPLMLX interacting protein like. (858 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1120 aa)
DUPD1Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (219 aa)
PAX2Paired box 2. (459 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
CRY1Cryptochrome circadian regulator 1. (588 aa)
H0WHZ3_OTOGAUncharacterized protein. (731 aa)
ADIPOR2Adiponectin receptor 2. (371 aa)
TFAP2BTranscription factor AP-2 beta. (462 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1347 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (599 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (324 aa)
SLC8B1Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (584 aa)
FOXA1Forkhead box A1. (449 aa)
FOXA3Forkhead box A3. (352 aa)
TWNKTwinkle mtDNA helicase. (684 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (372 aa)
H0XZF0_OTOGA40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (238 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
VGFVGF nerve growth factor inducible. (617 aa)
HK2Hexokinase 2. (918 aa)
SOX4Transcription factor SOX. (476 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
H0XVZ9_OTOGAUncharacterized protein. (528 aa)
GCKPhosphotransferase. (466 aa)
H0XUR5_OTOGABHLH domain-containing protein. (208 aa)
GAS6Growth arrest specific 6. (675 aa)
MEN1Menin 1. (607 aa)
H0XU07_OTOGAUncharacterized protein. (230 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
H0XTL6_OTOGADUF3496 domain-containing protein. (398 aa)
SRFSerum response factor. (509 aa)
FOXO1Forkhead box O1. (655 aa)
H0XSZ0_OTOGAWD_REPEATS_REGION domain-containing protein. (215 aa)
ZNF236Zinc finger protein 236. (1778 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (318 aa)
LRRC8ALeucine rich repeat containing 8 family, member A (Predicted). (730 aa)
CRTC2CREB regulated transcription coactivator 2. (693 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (476 aa)
POMCProopiomelanocortin. (265 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RMI1RecQ mediated genome instability 1. (621 aa)
HECTD4HECT domain E3 ubiquitin protein ligase 4. (3817 aa)
H0XMX4_OTOGALipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (191 aa)
H0XMW9_OTOGAANK_REP_REGION domain-containing protein. (1597 aa)
FFAR1Free fatty acid receptor 1. (295 aa)
ZBTB20Zinc finger and BTB domain containing 20. (737 aa)
NPTX1Neuronal pentraxin 1. (432 aa)
AGERAdvanced glycosylation end-product specific receptor. (414 aa)
CYB5R4Cytochrome b5 reductase 4. (538 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
BHLHA15Basic helix-loop-helix family member a15. (187 aa)
LRRC8DLeucine rich repeat containing 8 VRAC subunit D. (858 aa)
GATA4GATA binding protein 4. (442 aa)
IGFBP5Insulin like growth factor binding protein 5. (271 aa)
OAS12'-5'-oligoadenylate synthetase 1. (380 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (549 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (317 aa)
RAI14Retinoic acid induced 14. (978 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (624 aa)
GCLMGlutamate-cysteine ligase modifier subunit. (274 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
SESN3Sestrin 3. (491 aa)
TCF7L2Transcription factor 7 like 2. (471 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (977 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (851 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (289 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (663 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
RBP4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (201 aa)
WFS1Wolframin ER transmembrane glycoprotein. (889 aa)
DHPSUncharacterized protein. (369 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
CSMD2CUB and Sushi multiple domains 2. (3430 aa)
RAB11FIP2RAB11 family interacting protein 2. (530 aa)
SIRT1Sirtuin 1. (742 aa)
GCGGlucagon. (180 aa)
CRY2Cryptochrome circadian regulator 2. (615 aa)
ASPSCR1ASPSCR1 tether for SLC2A4, UBX domain containing. (553 aa)
SLC12A7Solute carrier family 12 member 7. (1085 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (374 aa)
IGF1RTyrosine-protein kinase receptor. (1158 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CPB2Carboxypeptidase B2. (422 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (466 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
RFX6Regulatory factor X6. (925 aa)
H0X5E7_OTOGAUncharacterized protein. (283 aa)
FGFR4Fibroblast growth factor receptor 4. (969 aa)
PPP3CASerine/threonine-protein phosphatase. (471 aa)
GPR1G protein-coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
ICAM1Intercellular adhesion molecule 1. (533 aa)
SLC39A14Solute carrier family 39 member 14. (490 aa)
NUCKS1Nuclear casein kinase and cyclin dependent kinase substrate 1. (221 aa)
SESN2Sestrin 2. (480 aa)
SELENOTSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (206 aa)
NCOA5Uncharacterized protein. (578 aa)
SLC37A4Solute carrier family 37 member 4. (429 aa)
FBN1Fibrillin 1. (2875 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
GCKRGlucokinase regulator. (524 aa)
H0WZZ9_OTOGAUncharacterized protein. (1348 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (976 aa)
RESP18RESP18 domain-containing protein. (175 aa)
RBM4RNA binding motif protein 4. (365 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (827 aa)
FOXK1Forkhead box K1. (631 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
RPH3ALRabphilin 3A like (without C2 domains). (303 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
HNF1AHNF1 homeobox A. (631 aa)
CARTPTCART prepropeptide. (116 aa)
CCDC186Coiled-coil domain containing 186. (953 aa)
FBN2Fibrillin 2. (2799 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (482 aa)
PAX6Paired box 6. (442 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (226 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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